Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. [PDF]
, 2006 MinK-related peptide 2 (MiRP2) and Kv3.4 subunits assemble in skeletal muscle to create subthreshold, voltage-gated potassium channels. MiRP2 acts on Kv3.4 to shift the voltage dependence of activation, speed recovery from inactivation, suppress ...
Abbott, Geoffrey W +2 more
core +1 more source
, 2017 Blockage of some ion channels and in particular, the hERG cardiac potassium channel delays cardiac repolarization and can induce arrhythmia. In some cases it leads to a potentially life-threatening arrhythmia known as Torsade de Pointes (TdP).
Buzatu, Dan +3 more
core +1 more source
Modulation of HERG K<sup>+</sup> Channels by Chronic Exposure to Activators and Inhibitors of PKA and PKC: Actions Independent of PKA and PKC Phosphorylation [PDF]
, 2013 Liliang Shu +5 more
openalex +1 more source
A superfamily of small potassium channel subunits: form and function of the MinK-related peptides (MiRPs). [PDF]
, 1998 MinK and MinK-related peptide I (MiRPI) are integral membrane peptides with a single transmembrane span. These peptides are active only when co-assembled with pore-forming K+ channel subunits and yet their role in normal ion channel behaviour is ...
Abbott, GW, Goldstein, SA
core
hERG toxicity assessment: Useful guidelines for drug design.
European journal of medicinal chemistry, 2020 Amanda Garrido +4 more
semanticscholar +1 more source
The conduction pore of a cardiac potassium channel. [PDF]
, 1998 Ion channels form transmembrane water-filled pores that allow ions to cross membranes in a rapid and selective fashion. The amino acid residues that line these pores have been sought to reveal the mechanisms of ion conduction and selectivity. The pore (P)
Goldstein, SA, Tai, KK
core
Phosphatidylinositol-4,5-Bisphosphate (PIP2) Stabilizes the Open Pore Conformation of the Kv11.1 (hERG) Channel [PDF]
, 2010 Nicolás Rodríguez +8 more
openalex +1 more source
Mechanism and pharmacological rescue of berberine-induced hERG channel deficiency
Drug Design, Development and Therapy, 2015 Meng Yan,1 Kaiping Zhang,1 Yanhui Shi,1 Lifang Feng,1 Lin Lv,1 Baoxin Li1,2 1Department of Pharmacology, Harbin Medical University, 2State-Province Key Laboratory of Biopharmaceutical Engineering, Harbin, Heilongjiang, People’s Republic of China ...
Yan M +5 more
doaj
Binding of Syntaxin 1A to the C-terminus of hERG Channels Affects Channel Trafficking and Inactivation [PDF]
, 2009 Anton Mihic +4 more
openalex +1 more source