Results 61 to 70 of about 36,434 (294)
Molecular medicine of microRNAs: structure, function and implications for diabetes [PDF]
, 2008 MicroRNAs (miRNAs) are a family of endogenous small noncoding RNA molecules, of 19–28 nucleotides in length. In humans, up to 3% of all genes are estimated to encode these evolutionarily conserved sequences.
Duncan +5 more
core +1 more source
Ruthenium Complexes in Protein Science: Heading a New Generation of Therapeutic and Analytical Tools
Angewandte Chemie, EarlyView.This review presents the latest advances in the development of ruthenium complexes within the field of protein science, highlighting their potential applications in biomedical and bioanalytical fields. Abstract Ruthenium complexes are distinguished by their versatile coordination chemistry, redox behaviors and photochemical properties. In recent years,
Liyan Zhang, Yun Chen, Sylvestre Bonnet
wiley +2 more sources
Pharmaceutical Biology, 2019 Context: Discovery of pharmacologically active natural products as starting points for drug development remains important and, for reasons of consumer safety, the identification of toxicologically relevant compounds in herbal drugs. Objective: To explain,
Matthias Hamburger
doaj +1 more source
Journal of Chemical Information and Modeling, 2020 The rise of novel artificial intelligence (AI) methods necessitates their benchmarking against classical machine learning for a typical drug-discovery project.
Vishal B. Siramshetty +5 more
semanticscholar +1 more source
High Glucose Represses hERG K+ Channel Expression through Trafficking Inhibition
Cellular Physiology and Biochemistry, 2015 Background/Aims: Abnormal QT prolongation is the most prominent cardiac electrical disturbance in patients with diabetes mellitus (DM). It is well known that the human ether-ago-go-related gene (hERG) controls the rapid delayed rectifier K+ current (IKr)
Yuan-Qi Shi +7 more
doaj +1 more source
Antipsychotics, HERG and sudden death [PDF]
British Journal of Psychiatry, 2003 The recent case—control study by Reilly et al ([2002][1]) showing an association between probable sudden unexplained death and current treatment with thioridazine in psychiatric in-patients underscores two fundamental issues essential for dealing with potential risks of this kind in the context ...
H J, Witchel +3 more
openaire +2 more sources
Berberine Induces hERG Channel Deficiency through Trafficking Inhibition
Cellular Physiology and Biochemistry, 2014 Aims: The human ether-a-go-go-related gene (hERG) encodes the α subunit of the IKr, which plays an essential role in repolarization of action potentials. hERG channels are targeted by various pro-arrhythmic drugs.
Kaiping Zhang +9 more
doaj +1 more source
Design, synthesis and antibacterial activity of minor groove binders: the role of non-cationic tail groups [PDF]
, 2012 he design and synthesis of a new class of minor groove binder (MGBs) in which, the cationic tail group has been replaced by a neutral, polar variant including cyanoguanidine, nitroalkene, and trifluoroacetamide groups.
Bourdin, Claire +9 more
core +1 more source
Kv4.3 Modulates the Distribution of hERG [PDF]
Scientific Reports, 2017 AbstractThis study examines the interaction between hERG and Kv4.3. The functional interaction between hERG and Kv4.3, expressed in a heterologous cell line, was studied using patch clamp techniques, western blot, immunofluorescence, and co-immunoprecipitation.
Zhao, Xiao-Jing +7 more
openaire +2 more sources
An orientation-based unification of young jetted AGN: the case of 3C 286 [PDF]
, 2017 In recent years, the old paradigm according to which only high-mass black holes can launch powerful relativistic jets in active galactic nuclei (AGN) has begun to crumble. The discovery of $\gamma$-rays coming from narrow-line Seyfert 1 galaxies (NLS1s),
Alessandro Caccianiga +10 more
core +3 more sources