Results 61 to 70 of about 31,297 (199)

Hypoxia induced hERG trafficking defect linked to cell cycle arrest in SH-SY5Y cells.

open access: yesPLoS ONE, 2019
The alpha subunit of the voltage gated human ether-a-go-go-related (hERG) potassium channel regulates cell excitability in a broad range of cell lines.
Damodara Reddy Vaddi   +5 more
doaj   +1 more source

Effects of Tannic Acid, Green Tea and Red Wine on hERG Channels Expressed in HEK293 Cells. [PDF]

open access: yesPLoS ONE, 2015
Tannic acid presents in varying concentrations in plant foods, and in relatively high concentrations in green teas and red wines. Human ether-à-go-go-related gene (hERG) channels expressed in multiple tissues (e.g.
Xi Chu   +7 more
doaj   +1 more source

Computational prediction of hERG blockers using homology modelling, molecular docking and QuaSAR studies

open access: yesResults in Chemistry, 2021
A full-length three-dimensional structure of the tetrameric potassium ion channel (hERG Kv11.1) including the N- and C-terminal domains was built, with a diameter of 6 Å and 12 Å between the K + selectivity filter and the pore cavity residue Tyr652 of ...
Nataraj Sekhar Pagadala
doaj   +1 more source

Compact steep-spectrum sources as the parent population of flat-spectrum radio-loud NLS1s [PDF]

open access: yes, 2016
Narrow-line Seyfert 1 galaxies (NLS1s) are an interesting subclass of active galactic nuclei (AGN), which tipically does not exhibit any strong radio emission.
Berton, Marco   +11 more
core   +2 more sources

Decoding Metamorphic Nanodiamonds Formation Through Their Internal Structures

open access: yesJournal of Metamorphic Geology, EarlyView.
ABSTRACT Metamorphic diamonds offer insights into Earth's evolution, modulating the global carbon cycle through subduction into the mantle and exhumation. However, the formation and internal structure of minute diamonds remain poorly understood. Here, we study the internal structures of diamond‐bearing inclusions from the Eastern Alps using state‐of ...
Tim Sotelšek   +8 more
wiley   +1 more source

HERG Protein Plays a Role in Moxifloxacin-Induced Hypoglycemia

open access: yesJournal of Diabetes Research, 2016
The purpose of this study was to investigate the effect of moxifloxacin on HERG channel protein and glucose metabolism. HERG expression was investigated using immunohistochemistry.
Hai-Yan Qiu   +4 more
doaj   +1 more source

Ion channels: structural basis for function and disease. [PDF]

open access: yes, 1996
Ion channels are ubiquitous proteins that mediate nervous and muscular function, rapid transmembrane signaling events, and ionic and fluid balance. The cloning of genes encoding ion channels has led to major strides in understanding the mechanistic basis
Goldstein, SA
core   +1 more source

Transgenic Tobacco Plants Expressing Synthetic Peptides: A Functional and Structural Analysis for Pathogen Resistance

open access: yesPlant Biotechnology Journal, EarlyView.
Peptide Power: VR18 & KG18 Shield Tobacco from Bacterial Attack. A schematic shows how antimicrobial peptides VR18 and KG18 fight Pseudomonas syringae—bursting bacterial membranes and boosting disease resistance in transgenic tobacco, without harming plant health.
Karishma Biswas   +17 more
wiley   +1 more source

Recent advances in our understanding of the structure and function of more unusual cation channels. [PDF]

open access: yes, 2019
As their name implies, cation channels allow the regulated flow of cations such as sodium, potassium, calcium, and magnesium across cellular and intracellular membranes.
Brown, Brandon M   +2 more
core   +1 more source

Prospective in silico trials identify combined SK and K2P channel block as an effective strategy for atrial fibrillation cardioversion

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend In silico trials were conducted in 654 virtual patients with atrial fibrillation (AF) to assess the cardioversion efficacy of three pharmacological treatments: single SK and K2P channel block and combined SK+K2P channel inhibition. Left: representative virtual AF patient with the atria inside the torso.
Albert Dasí   +4 more
wiley   +1 more source

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