Results 81 to 90 of about 33,807 (258)
An orientation-based unification of young jetted AGN: the case of 3C 286 [PDF]
, 2017 In recent years, the old paradigm according to which only high-mass black holes can launch powerful relativistic jets in active galactic nuclei (AGN) has begun to crumble. The discovery of $\gamma$-rays coming from narrow-line Seyfert 1 galaxies (NLS1s),
Alessandro Caccianiga +10 more
core +3 more sources
Revealing Molecular Determinants of hERG Blocker and Activator Binding
Journal of Chemical Information and Modeling, 2019 The Kv11.1 potassium channel, encoded by the human ether-a-go-go-related gene (hERG), plays an essential role in the cardiac action potential. hERG blockade by small molecules can induce "torsade de pointes" arrhythmias and sudden death; as such, it is ...
Callum J. Dickson +2 more
semanticscholar +1 more source
Epilepsia, EarlyView.Abstract Epilepsy is a chronic neurological condition marked by recurrent, uncontrolled seizures. Identifying comorbidities in epilepsy is critical for preventing mortality. Among these, the autonomic nervous system's role in epilepsy often manifests as cardiac disorders. Patients with epilepsy (PWE), particularly those with poorly controlled seizures,
Enes Akyuz +2 more
wiley +1 more source
Hierarchical Cont-Bouchaud model [PDF]
, 2015 We extend the well-known Cont-Bouchaud model to include a hierarchical topology of agent's interactions. The influence of hierarchy on system dynamics is investigated by two models. The first one is based on a multi-level, nested Erdos-Renyi random graph
Holyst, Janusz A. +2 more
core +1 more source
Construction of an integrated database for hERG blocking small molecules
PLoS ONE, 2018 The inhibition of the hERG potassium channel is closely related to the prolonged QT interval, and thus assessing this risk could greatly facilitate the development of therapeutic compounds and the withdrawal of hazardous marketed drugs.
Tomohiro Sato +3 more
semanticscholar +1 more source
Inhibitory effect of oestradiol on the cardiac KV7.1/KCNE1 channel is species dependent
Experimental Physiology, EarlyView.Abstract Oestradiol (17β‐E2) is reported to prolong the cardiac action potential duration and QT interval, in part by affecting cardiac ion channels. Previous studies found inhibiting 17β‐E2 effects on the repolarizating cardiac KV7.1/KCNE1 channel, or its native current, in heterologous expression systems or tissue from animal species.
Veronika A. Linhart +2 more
wiley +1 more source
Scientific Reports, 2019 The human ether-a-go-go-related gene (hERG) encodes a voltage-gated potassium channel that plays an essential role in the repolarization of action potentials in cardiac muscle.
Tatsuki Negami +3 more
semanticscholar +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend In silico trials were conducted in 654 virtual patients with atrial fibrillation (AF) to assess the cardioversion efficacy of three pharmacological treatments: single SK and K2P channel block and combined SK+K2P channel inhibition. Left: representative virtual AF patient with the atria inside the torso.
Albert Dasí +4 more
wiley +1 more source
Blockade of the Human Ether A-Go-Go–Related Gene (hERG) Potassium Channel by Fentanyl
Molecular Pharmacology, 2019 The human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel (IKr). Drug-mediated or medical condition–mediated disruption of hERG function is the primary cause of acquired ...
J. Tschirhart +3 more
semanticscholar +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend In this study, we use human‐induced pluripotent stem cell‐derived cardiomyocyte (hiPSC‐CM) experiments and computational modelling to identify the mechanism of action of drug compounds. In the hiPSC‐CM experiments, optical measurements of cell collections are recorded in the baseline case and after drug exposure.
Karoline Horgmo Jæger +4 more
wiley +1 more source