Results 151 to 160 of about 170,139 (366)

Prospective pathways between heroin use and nonmedical use of prescription opioids: Trajectories among young Swiss men [PDF]

open access: yes, 2015
BACKGROUND. So far few studies have focused on the last steps of drug-use trajectories. Heroin has been described as a final stage, but the non-medical use of prescription opioids (NMUPOs) is often associated with heroin use.
Baggio, S.   +7 more
core  

Towards a Better Understanding of the Lived Experience of Carers of People With Bipolar Disorder: A Mixed‐Methods Study

open access: yesBipolar Disorders, EarlyView.
ABSTRACT Background Caring for someone with Bipolar disorder (BD) is unique, and the severity and complexity of symptoms can overwhelm informal carers such as family, friends, and partners. Aim This study employed a concurrent mixed‐methods model to investigate the lived experience of informal carers caring for those with BD in Australia.
Juliet Robinson   +3 more
wiley   +1 more source

Normalizing effect of heroin maintenance treatment on stress-induced brain connectivity [PDF]

open access: yes, 2017
A single dose of heroin can reduce stress responses in heroin-dependent patients. Schmidt et al. report that increased amygdala-related functional connectivity during fearful face processing in heroin-dependent patients transiently normalises after a ...
Borgwardt, Stefan   +8 more
core  

(2R,6R)‐hydroxynorketamine prevents opioid abstinence‐related negative affect and stress‐induced reinstatement in mice

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Opioid use disorder (OUD) is a pressing public health concern marked by frequent relapse during periods of abstinence, perpetuated by negative affective states. Classical antidepressants or the currently prescribed opioid pharmacotherapies have limited efficacy to reverse the negative affect or prevent relapse ...
Andria Michael   +7 more
wiley   +1 more source

Forging a Path for Abstinence from Heroin: A grounded theory of detoxification-seeking

open access: yesGrounded Theory Review: An International Journal, 2011
Through a classic grounded theory approach, this study conceptualises that the main concern of heroin users who are seeking detoxification is giving up heroin use; ‘getting clean.’Forging a path for abstinence explains how people respond to their concern
Marie Claire Van Hout, BSc.,MSc., PhD.   +1 more
doaj  

Behavioural and pharmacokinetic analysis of heroin and cocaine self‐administration: Effects of timeout on self‐administration and choice in male rats

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Heroin and cocaine users tailor their dosage, frequency and administration route to maximise the drugs' effects or prevent withdrawal symptoms. Counterintuitively, preclinical self‐administration and choice experiments employ, almost invariably and regardless of the pharmacokinetic properties of the drug under examination, fixed ...
Ginevra D'Ottavio   +18 more
wiley   +1 more source

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