Results 21 to 30 of about 48,510 (233)

Pathways to age of onset of heroin use: a structural model approach exploring the relationship of the COMT gene, impulsivity and childhood trauma. [PDF]

PLoS ONE, 2012
The interaction of the association of dopamine genes, impulsivity and childhood trauma with substance abuse remains unclear.To clarify the impacts and the interactions of the Catechol -O-methyltransferase (COMT) gene, impulsivity and childhood trauma on ...
Ting Li, Jiang Du, Shunying Yu, Haifeng Jiang, Yingmei Fu, Dongxiang Wang, Haiming Sun, Hanhui Chen, Min Zhao   +8 more
doaj   +1 more source

DNA methyltransferase activity in the basolateral amygdala is critical for reconsolidation of a heroin reward memory

Frontiers in Molecular Neuroscience, 2022
The persistence of drug memory contributes to relapse to drug seeking. The association between repeated drug exposure and drug-related cues leads to cravings triggered by drug-paired cues.
Shuyi Qian, Cuijie Shi, Shihao Huang, Chang Yang, Yixiao Luo   +4 more
doaj   +1 more source

Extracellular signal-regulated kinase in the basolateral amygdala is required for reconsolidation of heroin-associated memory

Frontiers in Molecular Neuroscience, 2022
Reconsolidation of heroin-associated memory is an independent memory process that occurs following retrieval, which is essential for the sustained capacity of an associative drug stimulus to precipitate heroin-seeking.
Haoyu Li, Haoyu Li, Haoyu Li, Ting Hu, Ting Hu, Ting Hu, Yanghui Zhang, Zijin Zhao, Zijin Zhao, Zijin Zhao, Qing Liu, Qing Liu, Qing Liu, Zihua Chen, Zihua Chen, Si Chen, Si Chen, Si Chen   +17 more
doaj   +1 more source

Quality of life and its correlates among heroin users in Taiwan

Kaohsiung Journal of Medical Sciences, 2011
The aims of this study were to compare the quality of life (QOL) between subjects with and without heroin use and to examine the association of QOL with sociodemographic characteristics, characteristics of heroin use, family support, and depression among
Chia-Nan Yen, Carol Sheei-Meei Wang, Tzu-Yun Wang, Hsiao-Fang Chen, Hsun-Cheng Chang, 顏嘉男, 王秀美, 王姿云, 陳小芳, 張訓誠   +9 more
doaj   +1 more source

Heroin maintenance for chronic heroin-dependent individuals [PDF]

Cochrane Database of Systematic Reviews, 2010
Several types of medications have been used for stabilizing heroin users: Methadone, Buprenorphine and levo-alpha-acetyl-methadol (LAAM.) The present review focuses on the prescription of heroin to heroin-dependent individuals.To compare heroin maintenance to methadone or other substitution treatments for opioid dependence regarding: efficacy and ...
Marica, Ferri, Marina, Davoli, Carlo A, Perucci   +2 more
openaire   +3 more sources

Buprenorphine is a weak dopamine releaser relative to heroin, but its pretreatment attenuates heroin‐evoked dopamine release in rats

Neuropsychopharmacology Reports, 2020
Aims The United States of America is currently in an opioid epidemic. Heroin remains the most lethal opioid option with its death rate increasing by over 500% in the last decade.
Dominic P. Isaacs, Ryan P. Leman, Thomas J. Everett, Hendrick Lopez‐Beltran, Lindsey R. Hamilton, Erik B. Oleson   +5 more
doaj   +1 more source

The societal cost of heroin use disorder in the United States.

PLoS ONE, 2017
ObjectiveHeroin use in the United States has reached epidemic proportions. The objective of this paper is to estimate the annual societal cost of heroin use disorder in the United States in 2015 US dollars.MethodsAn analytic model was created that ...
Ruixuan Jiang, Inyoung Lee, Todd A Lee, A Simon Pickard   +3 more
doaj   +1 more source

Association of frontal gray matter volume and cerebral perfusion in heroin addiction: A multimodal neuroimaging study

Frontiers in Psychiatry, 2013
Structure and function in the human healthy brain are closely related. In patients with chronic heroin exposure, brain imaging studies have identified long-lasting changes in gray matter (GM) volume.
Niklaus eDenier, André eSchmidt, Hana eGerber, Otto eSchmid, Anita eRiecher-Rössler, Gerhard eWiesbeck, Christian G. Huber, Undine E. Lang, Ernst-Wilhelm eRadue, Marc eWalter, Stefan eBorgwardt, Stefan eBorgwardt   +11 more
doaj   +1 more source

Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

Advanced Science, EarlyView.
This review delineates monoaminylation—serotonylation, dopaminylation, and histaminylation—as key post‐translational modifications beyond receptor signaling. It details their catalytic mechanisms, roles in gene expression and protein function, and implications in health and disease, aiming to bridge mechanistic insights with therapeutic potential ...
Yiqi Zhao, Hongli Zhang, Yating Yang, Wei‐Dong Chen, Yan‐Dong Wang   +4 more
wiley   +1 more source

Using a pragmatically adapted, low-cost contingency management intervention to promote heroin abstinence in individuals undergoing treatment for heroin use disorder in UK drug services (PRAISE): a cluster randomised trial

BMJ Open, 2021
Introduction Most individuals treated for heroin use disorder receive opioid agonist treatment (OAT)(methadone or buprenorphine). However, OAT is associated with high attrition and persistent, occasional heroin use.
Julian Mutz, Andrew Pickles, Sarah Byford, John Dunn, Kimberley Goldsmith, Franziska Mosler, Tim Weaver, James Shearer, Emily Finch, John Strang, Clare Davey, Stephen Pilling, Anthony Glasper, Nicola Metrebian, Jennifer Hellier, Luke Mitcheson, Prun Bijral, Nadine Bogdan, Owen Bowden-Jones, Edward Day, Sam Forshall, Shabana Akhtar, Jalpa Bajaria, Carmel Bennett, Elizabeth Bishop, Vikki Charles, Roopal Desai, Claire Goodfellow, Farjana Haque, Nicholas Little, Hortencia McKechnie, Jo Morris, Ruth Pauli, Dilkushi Poovendran, Elizabeth Phillips   +34 more
doaj   +1 more source