Results 21 to 30 of about 179,765 (329)

Heroin addiction: the past and future [PDF]

open access: yes, 2008
Substance misuse, in particular heroin addiction contributes to health and social problems. Although effective medical treatment was available, earlier efforts confined the treatment of heroin addicts to in-house rehabilitation which required them to be ...
AR, Rusdi   +3 more
core   +1 more source

Initiation to heroin injecting among heroin users in Sydney, Australia: cross sectional survey

open access: yesHarm Reduction Journal, 2005
Background Heroin injection is associated with health and social problems including hepatitis C virus (HCV) transmission. Few studies have examined the circumstances surrounding initiation to heroin injecting, especially current users initiating others ...
Day Carolyn A   +3 more
doaj   +1 more source

Reduction in cerebral perfusion after heroin administration: a resting state arterial spin labeling study. [PDF]

open access: yesPLoS ONE, 2013
Heroin dependence is a chronic relapsing brain disorder, characterized by the compulsion to seek and use heroin. Heroin itself has a strong potential to produce subjective experiences characterized by intense euphoria, relaxation and release from craving.
Niklaus Denier   +8 more
doaj   +1 more source

Smoking heroin with cannabis versus injecting heroin: unexpected impact on treatment outcomes

open access: yesHarm Reduction Journal, 2019
Background In several countries, especially in Africa, the dominant method of heroin intake is smoking a joint of cannabis laced with heroin. There is no data exploring the impact of smoking heroin with cannabis on treatment outcomes.
Nirvana Morgan   +2 more
doaj   +1 more source

Modelling Long-Term Joint Trajectories of Heroin Use and Treatment Utilisation: Findings from the Australian Treatment Outcome Study

open access: yesEClinicalMedicine, 2019
Background: Heroin is currently contributing to the worst drug addiction epidemic in United States history; recent rates of use, dependence and death have also increased dramatically in parts of Europe.
Christina Marel   +5 more
doaj   +1 more source

Reciprocal Substitution Between Methamphetamine and Heroin in Terms of Reinforcement Effects in Rats

open access: yesFrontiers in Psychiatry, 2020
Heroin and methamphetamine are both popular illicit drugs in China. Previous clinical data showed that habitual users of either heroin or methamphetamine abuse the other drug for substitution in case of unavailability of their preferred drug. The present
Di-sen Mei   +9 more
doaj   +1 more source

Heroin and its metabolites: relevance to heroin use disorder

open access: yesTranslational Psychiatry, 2023
Heroin is an opioid agonist commonly abused for its rewarding effects. Since its synthesis at the end of the nineteenth century, its popularity as a recreational drug has ebbed and flowed.
Michele Stanislaw Milella   +5 more
doaj   +1 more source

Negative Mood Induction Increases Choice of Heroin Versus Food Pictures in Opiate-Dependent Individuals: Correlation With Self-Medication Coping Motives and Subjective Reactivity

open access: yesFrontiers in Psychiatry, 2019
Acute growth in negative affect is thought to play a major role in triggering relapse in opiate-dependent individuals. Consistent with this view, three lab studies have demonstrated that negative mood induction increases opiate craving in opiate ...
Lee Hogarth   +8 more
doaj   +1 more source

Pathways to age of onset of heroin use: a structural model approach exploring the relationship of the COMT gene, impulsivity and childhood trauma. [PDF]

open access: yesPLoS ONE, 2012
The interaction of the association of dopamine genes, impulsivity and childhood trauma with substance abuse remains unclear.To clarify the impacts and the interactions of the Catechol -O-methyltransferase (COMT) gene, impulsivity and childhood trauma on ...
Ting Li   +8 more
doaj   +1 more source

DNA methyltransferase activity in the basolateral amygdala is critical for reconsolidation of a heroin reward memory

open access: yesFrontiers in Molecular Neuroscience, 2022
The persistence of drug memory contributes to relapse to drug seeking. The association between repeated drug exposure and drug-related cues leads to cravings triggered by drug-paired cues.
Shuyi Qian   +4 more
doaj   +1 more source

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