Genome-Wide Association of Heroin Dependence in Han Chinese. [PDF]
PLoS One, 2016 Drug addiction is a costly and recurring healthcare problem, necessitating a need to understand risk factors and mechanisms of addiction, and to identify new biomarkers.
Kalsi G +12 more
europepmc +9 more sources
Association analysis of GABRB3 promoter variants with heroin dependence. [PDF]
PLoS One, 2014 GABRB3 encoding the β3 subunit of GABAA receptor has been implicated in multiple neuropsychiatric disorders, including substance abuse. Previous studies reported that SNPs at the 5' regulatory region of GABRB3 could regulate GABRB3 gene expression and ...
Chen CH, Huang CC, Liao DL.
europepmc +4 more sources
Chronic heroin dependence leading to adrenal insufficiency. [PDF]
Case Rep Endocrinol, 2014 Opioids have been the mainstay for pain relief and palliation over a long period of time. They are commonly abused by drug addicts and such dependence usually imparts severe physiologic effects on multiple organ systems. The negative impact of opioids on
Das G.
europepmc +6 more sources
Comorbidity of Mental Disorder in Patients with Chronic Disease: A Comparative Study of Heroin Dependence Patients and Diabetes Mellitus Patients. [PDF]
Iran J Public Health, 2022 Background: Chronic patients are at greater risk for a psychiatric problem than the normal population; yet, the increased rate of mental disorder among one chronic patient compared to another chronic patient is uncertain.
Seghatoleslam T +3 more
europepmc +2 more sources
The Association of Altered Gut Microbiota and Intestinal Mucosal Barrier Integrity in Mice With Heroin Dependence. [PDF]
Front Nutr, 2021 The gut microbiota is believed to play a significant role in psychological and gastrointestinal symptoms in heroin addicts. However, the underlying mechanism remains largely unknown. We show here that heroin addicts had a decrease in body mass index (BMI)
Yang J +12 more
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Association studies of dopamine synthesis and metabolism genes with multiple phenotypes of heroin dependence. [PDF]
BMC Med Genet, 2020 Background Heroin dependence is a complex disease with multiple phenotypes. Classification of heroin users into more homogeneous subgroups on the basis of these phenotypes could help to identify the involved genetic factors and precise treatments.
Li Y +6 more
europepmc +2 more sources
Australian treatment outcome study: protocol for the 18-20-year follow-up of a prospective longitudinal cohort examining the natural history of heroin dependence and associated mortality, psychiatric and physical health, and health service use. [PDF]
BMJ Open, 2020 Introduction Opioid dependence is a global health priority, currently making the biggest contribution to drug-related deaths. The chronic, long-term persistence of heroin dependence over the life course requires investigation in prospective longitudinal ...
Marel C +11 more
europepmc +2 more sources
Risk of Heroin Dependence in Newly Incident Heroin Users. [PDF]
JAMA Psychiatry, 2018 This study assesses data from the 2002 to 2016 US National Survey on Drug Use and Health data sets to determine the percentage of newly incident heroin users who became heroin dependent.
Santiago Rivera OJ +3 more
europepmc +4 more sources
GABRB2 Haplotype Association with Heroin Dependence in Chinese Population. [PDF]
PLoS One, 2015 Substance dependence is a frequently observed comorbid disorder in schizophrenia, but little is known about genetic factors possibly shared between the two psychotic disorders.
Kim YS +14 more
europepmc +2 more sources
Association between serotonin transporter gene polymorphisms and heroin dependence: a meta-analytic study. [PDF]
Neuropsychiatr Dis Treat, 2016 Pao-Yen Lin,* Yi-Shan Wu* Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan *These authors contributed equally to this work Background: Studies have examined the ...
Lin PY, Wu YS.
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