Results 41 to 50 of about 1,016,909 (195)

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Assessing cue-induced brain response as a function of abstinence duration in heroin-dependent individuals: an event-related fMRI study. [PDF]

PLoS ONE, 2013
The brain activity induced by heroin-related cues may play a role in the maintenance of heroin dependence. Whether the reinforcement or processing biases construct an everlasting feature of heroin addiction remains to be resolved.
Qiang Li, Yarong Wang, Yi Zhang, Wei Li, Jia Zhu, Ying Zheng, Jiajie Chen, Liyan Zhao, Zhenyu Zhou, Yijun Liu, Wei Wang, Jie Tian   +11 more
doaj   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Differences in onset and abuse/dependence episodes between prescription opioids and heroin: results from the National Epidemiologic Survey on Alcohol and Related Conditions

Substance Abuse and Rehabilitation, 2011
Li-Tzy Wu1, George E Woody2, Chongming Yang3, Paolo Mannelli1, Dan G Blazer11Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Duke University Medical Center, Durham, NC, USA; 2Department of Psychiatry, University of ...
Mannelli P, Yang C, Woody GE, Wu LT, Blazer DG   +4 more
doaj  

Medical diagnoses associated with substance dependence among inpatients at a large urban hospital.

PLoS ONE, 2015
BackgroundThere are limited data on reasons for hospital admission among patients dependent on substances other than alcohol. We compared primary discharge diagnoses for heroin- or cocaine-dependent patients to non-dependent patients.Material and ...
Humberto Choi, Anne Krantz, Jennifer Smith, William Trick   +3 more
doaj   +1 more source

Rate and Predictors of Severe Withdrawal Symptoms in an Accelerated Opioid Detoxification Program

Psychiatry and Clinical Psychopharmacology, 2021
Background: Opioid addicts usually quit treatment due to the severe withdrawal symptoms associated with it. Accelerated opioid detoxification programs were launched with the aim of making the detoxification process easier to complete for opioid patients
Ozge Kalkan, Kultegin Ogel, Gizem Pozam, Hakan Sari   +3 more
doaj   +1 more source

Scalable Room‐Temperature Terahertz Graphene Cameras

Small Methods, EarlyView.
ABSTRACT Terahertz (THz) imaging has emerged as a powerful tool for non‐destructive, label‐free analysis across several scientific disciplines, ranging from materials science to biomedical research. By capturing the spatial‐dependent information in a broad range of frequencies, this technique enables the identification of chemical composition ...
Lili Shi, Leonardo Viti, Miriam S. Vitiello   +2 more
wiley   +1 more source

Opioid substitution treatment and heroin dependent adolescents: reductions in heroin use and treatment retention over twelve months

BMC Pediatrics, 2018
Background Opioid dependence is a major health concern across the world and does also occur in adolescents. While opioid substitution treatment (OST) has been thoroughly evaluated in adult populations, very few studies have examined its use in ...
Bobby P. Smyth, Khalifa Elmusharaf, Walter Cullen   +2 more
doaj   +1 more source

The Dark Pyramid: Unpacking the Multidimensional Nature of the Dark Side of Leadership

British Journal of Management, EarlyView.
Abstract The dark side of leadership has been employed as an umbrella term to cover an array of concepts typically concerned with the dysfunctionality and/or toxicity of individual leaders. As the field of leadership studies moves towards ‘post‐heroic’ perspectives, we apply the same ontological positioning, adopting a ‘post‐villainous’ perspective in ...
Peter Stephenson, Richard Bolden, Morgen Witzel   +2 more
wiley   +1 more source

The wider network of social relationships and desistance from crime

Criminology, EarlyView.
Abstract Prior research has focused on marriage as a key relationship associated with crime cessation. Yet particularly within the contemporary context, relationships with parents, peers, and other family members may also foster or inhibit progress toward desistance.
Peggy C. Giordano, Jennifer E. Copp, Megan Swinehart, Wendy D. Manning, Monica A. Longmore   +4 more
wiley   +1 more source