Results 21 to 30 of about 1,032 (159)

Repeated Episodes of Heroin Cause Enduring Alterations of Circadian Activity in Protracted Abstinence

Brain Sciences, 2012
Opiate withdrawal is followed by a protracted abstinence syndrome consisting of craving and physiological changes. However, few studies have been dedicated to both the characterization and understanding of these long-term alterations in post-dependent ...
Luis Stinus, Martine Cador, Stephanie Caille   +2 more
doaj   +1 more source

Australian treatment outcome study: protocol for the 18–20-year follow-up of a prospective longitudinal cohort examining the natural history of heroin dependence and associated mortality, psychiatric and physical health, and health service use

BMJ Open, 2020
Introduction Opioid dependence is a global health priority, currently making the biggest contribution to drug-related deaths. The chronic, long-term persistence of heroin dependence over the life course requires investigation in prospective longitudinal ...
Maree Teesson, Paul S Haber, Christina Marel, Katherine Mills, Rachel Visontay, Jack Wilson, Shane Darke, Joanne Ross, Tim Slade, Katherine Haasnoot, Madeleine Keaveny, Chris Tremonti   +11 more
doaj   +1 more source

Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence. [PDF]

PLoS ONE, 2013
BACKGROUND: Heroin dependence is a debilitating psychiatric disorder with complex inheritance. Since the dopaminergic system has a key role in rewarding mechanism of the brain, which is directly or indirectly targeted by most drugs of abuse, we focus on ...
Andrea Vereczkei, Zsolt Demetrovics, Anna Szekely, Peter Sarkozy, Peter Antal, Agnes Szilagyi, Maria Sasvari-Szekely, Csaba Barta   +7 more
doaj   +1 more source

Treatment of heroin dependence with ibogaine

European Psychiatry, 2016
BackgroundThe use of the hallucinogen ibogaine as an anti-addiction agent has been described in several case reports, dating back to the eighties. The anti-addiction properties of ibogaine have been confirmed in a large body of animal work. Ibogaine has been shown to be effective in reducing withdrawal severity and substance use for a variety of ...
Schellekens, A.F.A., Oosteren, A.A. van, Knuijver, T., Verkes, R.J., Belgers, M.H.M.   +4 more
openaire   +3 more sources

Evaluation of the Association of Htr2a Gene Rs6313 Polymorphism with Heroin Dependence in a Sample from Northwest Iran

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2021
Introduction: Heroin dependence is a chronic relapsing disorder caused by a combination of genetic, epigenetic, and environmental factors. The genetic contribution in the vulnerability to heroin dependence is 40%-60%. Alterations in dopamine transport in
Fatemeh Mahmoudi, Leila Mehdizadeh fanid, Narges Zeinalzadeh, Mohammad ali Hosseinpour feizy   +3 more
doaj  

Reduction in cerebral perfusion after heroin administration: a resting state arterial spin labeling study. [PDF]

PLoS ONE, 2013
Heroin dependence is a chronic relapsing brain disorder, characterized by the compulsion to seek and use heroin. Heroin itself has a strong potential to produce subjective experiences characterized by intense euphoria, relaxation and release from craving.
Niklaus Denier, Hana Gerber, Marc Vogel, Markus Klarhöfer, Anita Riecher-Rossler, Gerhard A Wiesbeck, Undine E Lang, Stefan Borgwardt, Marc Walter   +8 more
doaj   +1 more source

Lack of Association between Human µ-Opioid Receptor (OPRM1) Gene Polymorphisms and Heroin Addiction in A Sample of Southeast Iranian Population

AIMS Medical Science, 2017
It has been proposed that genetic factors account for 30%–50% of the risk for cocaine and heroin addiction. The present study was aimed to find out the impact of µ-opioid receptor gene (OPRM1) rs1799971 A > G and rs9479757 polymorphisms on heroin ...
Mansour Shakiba, Mohammad Hashemi, Zahra Rahbari, Salah Mahdar, Hiva Danesh, Fatemeh Bizhani, Gholamreza Bahari   +6 more
doaj   +1 more source

The Chinese version of obsessive compulsive drug use scale: validation in outpatient methadone maintenance treatment program

BMC Psychiatry, 2020
Background The Obsessive Compulsive Drug Use Scale (OCDUS) measures the overall craving level within a period from a multidimensional perspective. However, no studies have addressed the validity of the new OCDUS factor structure, presented in 2016, in ...
Hengfen Gong, Yingying Zhang, Qihuan Ren, Zhirong Zhou, Huijing Zhou, Xirong Sun, Chencheng Zhang, Valerie Voon, Min Zhao, Shunying Yu   +9 more
doaj   +1 more source

Effects of Psychopathy on Neurocognitive Domains of Impulsivity in Abstinent Opiate and Stimulant Users

Frontiers in Psychiatry, 2021
Background: Psychopathy and substance use disorders (SUDs) are both characterized by neurocognitive impairments reflecting higher levels of impulsivity such as reward-driven decision-making and deficient inhibitory control.
Elena Psederska, Elena Psederska, Nicholas D. Thomson, Nicholas D. Thomson, Kiril Bozgunov, Dimitar Nedelchev, Georgi Vasilev, Jasmin Vassileva, Jasmin Vassileva   +8 more
doaj   +1 more source

Caregiver burden on wives of substance-dependent husbands and its correlates at a Tertiary Care Centre in Northern India

Indian Journal of Public Health, 2017
Background: Substance dependence is well recognized as a complex biopsychosocial phenomenon. Complications arising out of it not only impairs life of substance-dependent patient but also causes enormous burden on their caregivers.
Bharat Singh Shekhawat, Shreyance Jain, Hariom Kumar Solanki   +2 more
doaj   +1 more source