Exendin-4 enhances GLP-1 signaling and reduces anxiety-like behaviors in male heroin withdrawal mice. [PDF]
PLoS OneAnxiety and depression significantly contribute to heroin relapse, and addressing these issues could lower relapse rates. The basolateral amygdala (BLA) and nucleus tractus solitarius (NTS) are involved in regulating these emotions, but the molecular ...
Xiang Y +9 more
europepmc +2 more sources
Chronic heroin dependence leading to adrenal insufficiency. [PDF]
Case Rep Endocrinol, 2014 Opioids have been the mainstay for pain relief and palliation over a long period of time. They are commonly abused by drug addicts and such dependence usually imparts severe physiologic effects on multiple organ systems. The negative impact of opioids on
Das G.
europepmc +2 more sources
Forging a Path for Abstinence from Heroin: A grounded theory of detoxification-seeking [PDF]
Grounded Theory Review: An International Journal, 2011 Through a classic grounded theory approach, this study conceptualises that the main concern of heroin users who are seeking detoxification is giving up heroin use; ‘getting clean.’Forging a path for abstinence explains how people respond to their concern
Marie Claire Van Hout, BSc.,MSc., PhD. +1 more
doaj +1 more source
Effect of PDYN rs2281285, rs2235749 and rs910080 gene polymorphisms on the intensity of depression symptoms and negative craving in heroin addicts [PDF]
Archives of Biological Sciences, 2021 The present study was undertaken to explore whether prodynorphin (PDYN) polymorphisms have an effect on the intensity of depressive symptoms and negative craving in heroin addicts in a sample of 100 heroin addicts and 108 controls.
Kaya-Akyüzlü Dilek +3 more
doaj +1 more source
Opium dependence and the potential impact of changes in treatment coverage level: A dynamic modeling study [PDF]
Health Promotion Perspectives, 2021 Background: The most common drug, illegally used in Iran is opium. The treatment of people with substance use disorder is one of the most important strategies in reducing its burden.
Hosein Rafiemanesh +8 more
doaj +1 more source
Variants of opioid system genes are associated with non-dependent opioid use and heroin dependence. [PDF]
Drug Alcohol Depend, 2016 Heroin addiction is a chronic, relapsing brain disease. Genetic factors are involved in the development of drug addiction. The aim of this study was to determine whether specific variants in genes of the opioid system are associated with non-dependent ...
Randesi M +9 more
europepmc +2 more sources
The Effect of Drug Abstinence Program on Memory Functioning of Heroin Addicts [PDF]
International Journal of Travel Medicine and Global Health, 2015 Introduction: Most of our knowledge regarding the link between opioid dependence and poor cognitive functioning is derived from cross sectional studies.This longitudinal study measured the change in memory functioning following complete abstinence among ...
Sepideh Aryanfard +5 more
doaj +1 more source
Direct, indirect and epistatic associations of reward system genes with heroin dependence [PDF]
, 2021 Objective: Genes encoding molecular pathways of the reward system are implicated in both addiction and impulsivity. A complex interplay of these genes is likely to contribute to the risk and perpetuation of addiction, both directly and indirectly ...
Daglish, M +6 more
core +1 more source
Heroin maintenance for chronic heroin-dependent individuals [PDF]
Cochrane Database of Systematic Reviews, 2010 Several types of medications have been used for stabilizing heroin users: Methadone, Buprenorphine and levo-alpha-acetyl-methadol (LAAM.) The present review focuses on the prescription of heroin to heroin-dependent individuals.To compare heroin maintenance to methadone or other substitution treatments for opioid dependence regarding: efficacy and ...
Marica, Ferri +2 more
openaire +3 more sources
Indian Journal of Psychiatry, 2021 Background: Craving is the subjective experience of desire for specific drugs. Lack of reliability and untested construct validity are limiting factors for the existing questionnaires to assess craving.
Shantanu Shukla +4 more
doaj +1 more source