Results 101 to 110 of about 269,557 (334)

Pregnancy and contraceptive use among women participating in an HIV prevention trial in Tanzania. [PDF]

, 2012
OBJECTIVES: Information on pregnancy rates and factors associated with pregnancy and contraceptive use is important for clinical trials in women in sub-Saharan Africa where withdrawal of investigational products may be required in the event of pregnancy ...
Baisley, Kathy, Changalucha, John, Hayes, Richard J, Odutola, Aderonke, Ross, David A, Rusizoka, Mary, Tanton, Clare, Watson-Jones, Deborah, Weiss, Helen A   +8 more
core   +1 more source

Ligand-based drug design against Herpes Simplex Virus-1 capsid protein by modification of limonene through in silico approaches

Scientific Reports
The pharmacological effects of limonene, especially their derivatives, are currently at the forefront of research for drug development and discovery as well and structure-based drug design using huge chemical libraries are already widespread in the early
Md. Rezaul Islam, Md. Shafiqul Islam Sovon, Ummy Amena, Miadur Rahman, Md. Eram Hosen, Ajoy Kumer, Mohammed Bourhia, Yousef A. Bin Jardan, Samir Ibenmoussa, Gezahign Fentahun Wondmie   +9 more
doaj   +1 more source

Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome. [PDF]

, 2019
Herpesviruses are enveloped viruses that are prevalent in the human population and are responsible for diverse pathologies, including cold sores, birth defects and cancers.
Bi, Guo-Qiang, Dai, Xinghong, Jih, Jonathan, Liu, Yun-Tao, Zhou, Z Hong   +4 more
core  

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, EarlyView.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

Herpes Simplex Virus-1 ICP27 Nuclear Export Signal Mutants Exhibit Cell Type-Dependent Deficits in Replication and ICP4 Expression

, 2023
Leon Sanders, Courtney E. Comar, Kalanghad Puthankalam Srinivas, Joseph Lalli, Mark Salnikov, Joy Lengyel, Peter J. Southern, Ian Mohr, Angus C. Wilson, Stephen A. Rice   +9 more
openalex   +1 more source

Acute severe cholestatic hepatitis and lymphopenia characterize pediatric hepatitis‐associated aplastic anemia

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Hepatitis‐associated aplastic anemia (HAAA) is described as acute severe hepatitis of unknown origin followed by bone marrow failure (BMF). We aimed to provide a comprehensive picture of pediatric HAAA. Methods Two‐center retrospective analysis was performed using data from children diagnosed with acquired BMF, including severe ...
Daniel Tegtmeyer, Sofia Tsaka, Kai Lehmberg, Michaela Höfs, Jan Beime, Andrea Briem‐Richter, Jun Oh, Elke Lainka, Sebastian Schulz‐Jürgensen   +8 more
wiley   +1 more source

Safety of Baricitinib for the Treatment of Atopic Dermatitis in Adults Over a Median of 1.6 and up to 4.6 Years Treatment: Final Integrated Analysis of Eight Clinical Trials

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Baricitinib is a selective Janus kinase (JAK)1/JAK2 inhibitor approved in more than 70 countries for the treatment of moderate‐to‐severe atopic dermatitis (AD) in adults, and in over 30 countries for adolescents and children from age 2 years with moderate‐to‐severe AD, who are candidates for systemic therapy.
Antonio Costanzo, Antonio Torrelo, Eric L. Simpson, Marjolein De Bruin‐Weller, Diamant Thaçi, Norito Katoh, Silvia Sabatino, Andrew Buchanan, Kasia Morawska, Samuel Ogwu, Karen Denning, Jonathan I. Silverberg   +11 more
wiley   +1 more source

Brainstem Lesions in Herpes Encephalitis

Türk Nöroloji Dergisi, 2010
Herpes simplex encephalitis typically involves the medial temporal and inferior frontal lobes; brainstem lesions are very unusual. We present a 42-year-old woman admitted with delirium and diagnosed as herpes simplex encephalitis.
Gülçin Benbir, Baki Göksan, Naci Koçer   +2 more
doaj   +2 more sources

Pityriasis Lichenoides Chronica Associated with Herpes Simplex Virus Type 2

Case Reports in Dermatological Medicine, 2012
Introduction. Pityriasis lichenoides is a rare, acquired spectrum of skin conditions of an unknown etiology. Case Report. A 28-year-old man presented with recurrent outbreaks of herpes simplex virus associated with the onset of red-to-brown maculopapules
Antonio Javier González Rodríguez, Encarnación Montesinos Villaescusa, Esperanza Jordá Cuevas   +2 more
doaj   +1 more source

Early Steps in Herpes Simplex Virus Infection Blocked by a Proteasome Inhibitor [PDF]

, 2019
Seth M. Schneider, Suzanne M. Pritchard, George A. Wudiri, Chasity E. Trammell, Anthony V. Nicola   +4 more
openalex   +1 more source