Results 51 to 60 of about 767,880 (263)

Cellular v-ATPase is required for virion assembly compartment formation in human cytomegalovirus infection [PDF]

Open Biology, 2017
Successful generation of virions from infected cells is a complex process requiring orchestrated regulation of host and viral genes. Cells infected with human cytomegalovirus (HCMV) undergo a dramatic reorganization of membrane organelles resulting in ...
Jonathan Pavelin, Dominique McCormick, Stephen Chiweshe, Saranya Ramachandran, Yao-Tang Lin, Finn Grey   +5 more
doaj   +1 more source

Evasion of Intracellular DNA Sensing by Human Herpesviruses

Frontiers in Cellular and Infection Microbiology, 2021
Sensing of viral constituents is the first and critical step in the host innate immune defense against viruses. In mammalian cells, there are a variety of pathogen recognition receptors (PRRs) that detect diverse pathogen-associated molecular patterns ...
Debipreeta Bhowmik, Fanxiu Zhu
doaj   +1 more source

A pentameric protein ring with novel architecture is required for herpesviral packaging

eLife, 2021
Genome packaging in large double-stranded DNA viruses requires a powerful molecular motor to force the viral genome into nascent capsids, which involves essential accessory factors that are poorly understood.
Allison L Didychuk, Stephanie N Gates, Matthew R Gardner, Lisa M Strong, Andreas Martin, Britt A Glaunsinger   +5 more
doaj   +1 more source

DOCK8 deficiency presenting with sclerosing cholangitis, raised immunoglobulin E, and bronchiectasis: A fatal pediatric case report

JPGN Reports, EarlyView.
Abstract Dedicator of cytokinesis 8 (DOCK8) deficiency is a rare autosomal recessive primary immunodeficiency. Patients with DOCK8 deficiency typically present at early age with allergic manifestations, cutaneous and respiratory infections, raised immunoglobulin E, and they have an increased risk of developing malignancies.
Natalia Nedelkopoulou, Kelechi Ugonna, Stephen Hughes, Sanjay Rajwal, Marumbo Mtegha   +4 more
wiley   +1 more source

Herpesviruses and Intermediate Filaments: Close Encounters with the Third Type

Viruses, 2011
Intermediate filaments (IF) are essential to maintain cellular and nuclear integrity and shape, to manage organelle distribution and motility, to control the trafficking and pH of intracellular vesicles, to prevent stress-induced cell death, and to ...
Laura Hertel
doaj   +1 more source

Hepatopulmonary syndrome as presentation of pediatric metabolic dysfunction‐associated steatohepatitis

JPGN Reports, EarlyView.
Abstract Childhood obesity is rising and leading to serious co‐morbidities, among which is metabolic dysfunction‐associated steatotic liver disease (MASLD) predisposing individuals to cirrhosis. We describe a young 11‐year‐old Hispanic male who presented with hepatopulmonary syndrome secondary to cirrhotic portal hypertension from metabolic dysfunction‐
Shruti Sakhuja, Stacey S. Beer, Kalyani R. Patel, Alexiss M. Williams, Nhu Thao Galvan, John A. Goss, Krupa R. Mysore   +6 more
wiley   +1 more source

Secondary Envelopment of Human Cytomegalovirus Is a Fast Process Utilizing the Endocytic Compartment as a Major Membrane Source

Biomolecules
Secondary envelopment of the human cytomegalovirus (HCMV) is a critical but not well-understood process that takes place at the cytoplasmic viral assembly complex (cVAC) where nucleocapsids acquire their envelope by budding into cellular membranes ...
Tim Bergner, Laura Cortez Rayas, Gesa Freimann, Clarissa Read, Jens von Einem   +4 more
doaj   +1 more source

Non‐Epidemic Kaposi Sarcoma Refractory to Laser Therapy in an HIV‐Negative Man Who Has Sex With Men (MSM)

JEADV Clinical Practice, EarlyView.
ABSTRACT Kaposi sarcoma (KS) is a vascular neoplasm associated with human herpesvirus 8 (HHV‐8), typically affecting immunocompromised individuals. However, emerging reports describe cases in HIV‐negative men who have sex with men (MSM), constituting a proposed non‐epidemic variant.
M. Sin‐Soler, M. Martins Lopes, I. Martín Loureiro, C. Giménez Grau, F. Sacristán Lista, J. del Pozo Losada   +5 more
wiley   +1 more source

Epstein-Barr virus: the mastermind of immune chaos

Frontiers in Immunology
The Epstein-Barr virus (EBV) is a ubiquitous human pathogen linked to various diseases, including infectious mononucleosis and multiple types of cancer.
Jean de Melo Silva, Jean de Melo Silva, Carlos Eduardo de Castro Alves, Gemilson Soares Pontes, Gemilson Soares Pontes   +4 more
doaj   +1 more source

MendelR: A One‐Stop R Toolkit for Mendelian Randomization Analysis

Med Research, EarlyView.
ABSTRACT MendelR is a fully automated R package specifically developed for Mendelian randomization (MR) studies, designed to address the technical challenges of causal inference in biomedical research. As a powerful causal inference method, Mendelian randomization can effectively reduce confounding bias in observational studies.
Xiaohong Ke, Kailai Li, Anqi Lin, Yasi Zhang, Peng Luo   +4 more
wiley   +1 more source