Results 81 to 90 of about 170,851 (306)

Developing FGF2 Mutants with Selectively Reduced Heparan Sulfate Affinity to Explore Their Impact on FGFR1 Signaling

ChemBioChem, Accepted Article.
Fibroblast growth factor 2 (FGF2) regulates signal transduction by forming complexes with its receptors, FGF receptors (FGFRs), and heparan sulfate (HS), playing a crucial role in biological systems. Although HS has been suggested to modulate FGF/FGFR signaling as a co‐receptor, multiple hypotheses exist regarding how HS affects FGF/FGFR signaling, and
Yuga Okada, Akihiro Eguchi, Daisuke Kuroda, Kouhei Tsumoto, Ryosuke Ueki, Shinsuke Sando   +5 more
wiley   +1 more source

Identification of AIDS-Associated Kaposi Sarcoma: A Functional Genomics Approach

Frontiers in Genetics, 2020
BackgroundKaposi sarcoma-associated herpes virus (KSHV) is one of the most common causal agents of Kaposi Sarcoma (KS) in individuals with HIV-infections.
Peng Zhang, Peng Zhang, Jiafeng Wang, Xiao Zhang, Xiaolan Wang, Liying Jiang, Xuefeng Gu   +6 more
doaj   +1 more source

Targeting Ubiquitin‐Specific Protease 7 with Novel 5‐Amino‐Pyrazole Inhibitors: Design, Synthesis, and Biological Evaluation

ChemMedChem, EarlyView.
Ubiquitin‐specific protease 7 (USP‐7) is a novel target for anticancer therapy. To further extend the structure–activity relationships of the previously USP‐7 inhibitor STIRUR‐41, a library of 5‐aminopyrazoles is reported. 1d shows a potency comparable to lead compound STIRUR‐41 and promising in silico and in vitro pharmacokinetic properties ...
Matteo Lusardi, Elva Morretta, Andrea Spallarossa, Maria Chiara Monti, Camillo Rosano, Erika Iervasi, Marco Ponassi, Matteo Mori, Fiorella Meneghetti, Chiara Brullo   +9 more
wiley   +1 more source

Current Progress in Targeting Human Cytomegalovirus Infection

iLABMED, EarlyView.
This review highlights recent advances in the mechanisms by which human cytomegalovirus (HCMV) maintains its genome in infected cells, as well as the cellular factors and viral antigens that modulate viral reactivation, which reveal potential targets for addressing HCMV infection.
Yonggang Pei, Jun Chen
wiley   +1 more source

Epstein-Barr virus BNRF1 destabilizes SMC5/6 cohesin complexes to evade its restriction of replication compartments

Cell Reports, 2022
Summary: Epstein-Barr virus (EBV) persistently infects people worldwide. Delivery of ∼170-kb EBV genomes to nuclei and use of nuclear membrane-less replication compartments (RCs) for their lytic cycle amplification necessitate evasion of intrinsic ...
Stephanie Pei Tung Yiu, Rui Guo, Cassie Zerbe, Michael P. Weekes, Benjamin E. Gewurz   +4 more
doaj  

Paediatric acute liver failure: A prospective, nationwide, population‐based surveillance study in Germany

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Paediatric acute liver failure (PALF) is a rare but life‐threatening condition, yet comprehensive epidemiological data in Germany are lacking. Our study aimed to systematically analyse incidence, aetiology, and outcome of PALF in Germany.
Dominic Lenz, Muhammad Abdulaziz, Bianca Peters, Matias Wagner, Lea D. Schlieben, Victor M. Corman, Ulrich Baumann, Philip Bufler, Tal Dattner, Rainer Ganschow, Kristin Genzel, Nicole Hammann, Steffen Hartleif, Bianca Hegen, Stephan Henning, André Hoerning, Martin Jankofsky, Norman Junge, Simone Kathemann, Birgit Knoppke, Martina Kohl‐Sobania, Martin Laass, Elke Lainka, Eberhard Lurz, Michael Melter, Hanna Müller, Denisa Pilic, Markus Ries, Lisa Schiefele, Tobias Schwerd, Ekkehard Sturm, Mechtild Wegner, Michael S. Urschitz, Sven F. Garbade, Daniel Wenning, Christian Drosten, Alexander Fichtner, Stefan Kölker, Georg F. Hoffmann, Holger Prokisch, Christian Staufner   +40 more
wiley   +1 more source

Tests for the presence of koi herpesvirus (KHV) in common carp (Cyprinus carpio carpio) and koi carp (Cyprinus carpio koi) in the Czech Republic

Veterinární Medicína, 2007
An outbreak of koi herpesvirus (KHV) infection associated with high mortality of common and koi carp was recorded in the USA and Israel in 1998. At present, this disease is viewed as one of the most significant factors that can adversely affect common ...
D. Pokorova, V. Piackova, A. Cizek, S. Reschova, J. Hulova, M. Vicenova, T. Vesely   +6 more
doaj   +1 more source

Herpesviral microRNAs in Cellular Metabolism and Immune Responses

Frontiers in Microbiology, 2017
The microRNAs (miRNAs) function as a key regulator in many biological processes through post-transcriptional suppression of messenger RNAs. Recent advancements have revealed that miRNAs are involved in many biological functions of cells.
Hyoji Kim, Hisashi Iizasa, Yuichi Kanehiro, Sintayehu Fekadu, Hironori Yoshiyama   +4 more
doaj   +1 more source

Molecular Detection and Genetic Characteristics of Equine Herpesvirus in Korea

Pathogens, 2020
Respiratory diseases cause significant economic losses (especially in the horse racing industry). The present study describes the detection and genetic characteristics of equine herpesvirus (EHV) from a total of 1497 samples from clinically healthy ...
Min-Goo Seo, In-Ohk Ouh, Sang Kyu Lee, Jong-Seok Lee, Oh-Deog Kwon, Dongmi Kwak   +5 more
doaj   +1 more source

Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses

PLoS Pathogens, 2015
The IL-1β and type I interferon-β (IFN-β) molecules are important inflammatory cytokines elicited by the eukaryotic host as innate immune responses against invading pathogens and danger signals.
M. A. Ansari, S. Dutta, M. Veettil, D. Dutta, J. Iqbal, B. Kumar, Arunava Roy, Leela Chikoti, Vivek Singh, B. Chandran   +9 more
semanticscholar   +1 more source