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Induction of Human Immunodeficiency Virus 1 Replication by Human Herpesvirus 8
Abstract Background.—Human immunodeficiency virus 1 (HIV-1)–infected individuals are commonly infected with herpesviruses, including cytomegalovirus, herpes simplex virus, varicella-zoster virus, and human herpesvirus 8 (HHV-8, also known as Kaposi sarcoma–associated herpesvirus [KSHV]).
M, Mercader +2 more
openaire +2 more sources
Structure of the herpes-simplex virus portal-vertex [PDF]
Herpesviruses include many important human pathogens such as herpes simplex virus, cytomegalovirus, varicella-zoster virus, and the oncogenic Epstein–Barr virus and Kaposi sarcoma–associated herpesvirus.
Bhella, David +3 more
core +2 more sources
<i>Objective:</i> Human herpesvirus 8 (HHV-8) is the etiologic agent of Kaposi’s sarcoma, the most common neoplasm in patients with acquired immunodeficiency syndrome. Current evidence indicates that activation of viral replication may be critical to the development of the disease. A key factor in the induction of HHV-8 lytic replication is
CASELLI, Elisabetta +3 more
openaire +2 more sources
Risk factors for high anti-HHV-8 antibody titers (≥1:51,200) in black, HIV-1 negative South African cancer patients: a case control study [PDF]
Background: Infection with human herpesvirus 8 (HHV-8) is the necessary causal agent in the development of Kaposi's sarcoma (KS). Infection with HIV-1, male gender and older age all increase risk for KS.
BM Friedman +51 more
core +2 more sources
Equine Herpesvirus Type 1-Mediated Oncolysis of Human Glioblastoma Multiforme Cells [PDF]
ABSTRACT The cytolytic animal virus equine herpesvirus type 1 (EHV-1) was evaluated for its oncolytic potential against five human glioblastoma cell lines. EHV-1 productively infected four of these cell lines, and the degree of infection was positively correlated with glioma cell death. No human major histocompatibility complex class 1 (MHC-I)
Michael J, Courchesne +3 more
openaire +2 more sources
Global Diversity within and between Human Herpesvirus 1 and 2 Glycoproteins [PDF]
ABSTRACT Human herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) are large-genome DNA viruses that establish a persistent infection in sensory neurons and commonly manifest with recurring oral or genital erosions that transmit virus. HSV encodes 12 predicted glycoproteins that serve various functions, including cellular attachment, entry, and ...
Susanna L, Lamers +9 more
openaire +2 more sources
The activation of KSHV lytic cycle blocks autophagy in PEL cells [PDF]
This study confirms that autophagy is activated concomitantly with KSHV lytic cycle induction, and that autophagy inhibition by BECN1 knockdown reduces viral lytic gene expression.
CIRONE, Mara +7 more
core +1 more source
Estudio genómico de cepas argentinas de Herpesvirus equino 1 [PDF]
La infección por Herpesvirus equino 1 (EHV-1) tiene un significativo impacto económico en la producción equina mundial al causar abortos, enfermedad respiratoria, muertes perinatales y desórdenes neurológicos.
Eöry, Matías Leonel +5 more
core +2 more sources
Analysis of the human herpesvirus-6 immediate-early 1 protein
Herpesvirus immediate-early (IE) gene products play key roles in establishing productive infections, regulating reactivation from latency and evading immune recognition. Analyses of HHV-6 IE gene expression have revealed that the IE1 gene of the HHV-6A and HHV-6B variants exhibits a higher degree of sequence variation than other regions of the genome ...
Richard, Stanton +4 more
openaire +2 more sources
Objective To evaluate the value of next⁃generation sequencing (NGS) of cerebrospinal fluid (CSF) in the diagnosis of human herpesvirus encephalitis/meningitis.
Ke JIN +10 more
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