Results 71 to 80 of about 16,403 (211)

Inhibition of Fat Accumulation by Hesperidin in Caenorhabditis elegans

, 2016
Hesperidin, abundant in citrus fruits, has a wide range of pharmacological effects, including anticarcinogenic, anti-inflammatory, antioxidative, radioprotective, and antiviral activities.
Hujie Luo (2830184), Huimin Peng (400123), Xiangliang Yang (322746), Yiting Yang (2830190), Zhaohan Wei (2830187), Lu Gan (33435), Zhengxing Wu (2830193)   +6 more
core   +1 more source

Advances in Unconventional and Sustainable Synthetic Approaches to Benzopyran Scaffolds

The Chemical Record, EarlyView.
This review provides a comprehensive and critical analysis of low‐impact synthetic methodologies reported in the last 8 years (2018–2026) for the construction of benzopyran‐derived scaffolds, such as coumarins, flavones, chromones, chromenes, and chromanes. The benzopyran scaffold is a versatile family of heterocycles found in a wide range of bioactive
Nathalia B. Sá, Patrick C. Nobre, Isabelly O. Ferreira, Juliano B. Azeredo, Vanessa Nascimento   +4 more
wiley   +1 more source

Hesperidin as a preventive resistance agent in MCF–7 breast cancer cells line resistance to doxorubicin

Asian Pacific Journal of Tropical Biomedicine, 2014
Objective: To evaluate of hesperidin to overcome resistance of doxorubicin in MCF-7 resistant doxorubicin cells (MCF-7/Dox) in cytotoxicity apoptosis and P-glycoprotein (Pgp) expression in combination with doxorubicin.
Rifki Febriansah, Dewi P.P. Dyaningtyas, Sarmoko, Nunuk Aries Nurulita, Edy Meiyanto, Agung Endro Nugroho   +5 more
doaj   +1 more source

Hesperidin produces cardioprotective activity via PPAR-γ pathway in ischemic heart disease model in diabetic rats. [PDF]

PLoS ONE, 2014
The present study investigated the effect of hesperidin, a natural flavonoid, in cardiac ischemia and reperfusion (I/R) injury in diabetic rats. Male Wistar rats with diabetes were divided into five groups and were orally administered saline once daily ...
Yogeeta O Agrawal, Pankaj Kumar Sharma, Birendra Shrivastava, Shreesh Ojha, Harshita M Upadhya, Dharamvir Singh Arya, Sameer N Goyal   +6 more
doaj   +1 more source

Beneficial Role of Natural Polyphenols Against Epilepsy: Greasing the Wheels of Pharmacotherapy Research for Epilepsy

Food Frontiers, Volume 7, Issue 6, November 2026.
ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan, Rengasamy Balakrishnan, Manivasagam Muthukumaran Tamilarasan, Subasri Pandian   +3 more
wiley   +1 more source

Hesperidin Increases Cytotoxic Effect of 5-Fluorouracil on WiDr Cells [PDF]

, 2012
oai:ojs.ijcc.chemoprev.org:article/63Therapy of colon cancer by using 5-FU often causes problems of resistance. This encourages the development of co-chemotherapy agent.
Yurista Gilang, Aditya Fitriasari, Gilang, Yurista, Hermawan, Adam, Fitriasari, Aditya, Adam Hermawan, Jenie, Riris Istighfari, Riris Istighfari Jenie   +7 more
core   +1 more source

Physiological regulation mechanism of hesperidin and the application in animal production

Siliao yanjiu, 2021
Hesperidin is a natural plant feed additive, which has physiological activity of antioxidant, anti-inflammatory, antibacterial and anticancer activities.
Qing LIU, Yun XU
doaj  

Anti-inflammatory effect of hesperidin enhances chondrogenesis of human mesenchymal stem cells for cartilage tissue repair

Journal of Inflammation, 2018
Background Articular cartilage diseases are considered a major health problem, and tissue engineering using human mesenchymal stem cells (MSCs) have been shown as a promising solution for cartilage tissue repair.
Shipeng Xiao, Wenguang Liu, Jianqiang Bi, Shenghou Liu, Heng Zhao, Ningji Gong, Deguo Xing, Hongwei Gao, Mingzhi Gong   +8 more
doaj   +1 more source

Network Pharmacology and In Vivo Evaluation of Modified Huanglian Wendan Decoction in Polycystic Ovary Syndrome With Insulin Resistance: Association With AGE–RAGE‐Related Signaling

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
An integrated network pharmacology, chemical profiling, molecular docking, molecular dynamics, and in vivo strategy shows that Modified Huanglian Wendan Decoction improves reproductive and metabolic abnormalities in a rat model of PCOS with insulin resistance.
Xi Chen, Xing Yang, Xinni Wang, Dan Chou, Chenghong Zheng   +4 more
wiley   +1 more source

The neuroprotective effect of hesperidin in NMDA-induced retinal injury acts by suppressing oxidative stress and excessive calpain activation

Scientific Reports, 2017
We found that hesperidin, a plant-derived bioflavonoid, may be a candidate agent for neuroprotective treatment in the retina, after screening 41 materials for anti-oxidative properties in a primary retinal cell culture under oxidative stress.
Shigeto Maekawa, Kota Sato, Kosuke Fujita, Reiko Daigaku, Hiroshi Tawarayama, Namie Murayama, Satoru Moritoh, Takeshi Yabana, Yukihiro Shiga, Kazuko Omodaka, Kazuichi Maruyama, Koji M. Nishiguchi, Toru Nakazawa   +12 more
doaj   +1 more source