Results 101 to 110 of about 85,707 (260)

Oocyte Age‐Dependent DNA Damage Can Be Reverted by the DNA Repair Competent Karyoplasm of Young Oocytes

Aging Cell, EarlyView.
As females age, oocyte chromosomal aberrations and DNA damage increase in frequency; this condition is believed to be irreversible. By exposing the aged oocyte nuclei to nuclear factors from young oocytes, the negative effects can be effectively suppressed, restoring their developmental competence. ABSTRACT Mammalian fully grown oocytes are believed to
Nataliia Dudko, Tereza Ilcikova, Natalie Novotna, Marta Czernik, Pasqualino Loi, Josef Fulka Jr., Pritha Bhattacharjee, Raffaella Santoro, Helena Fulka   +8 more
wiley   +1 more source

Tissue-specific chromatin binding patterns ofC. elegansheterochromatin proteins HPL-1 and HPL-2 reveal differential roles in the regulation of gene expression [PDF]

, 2023
Patricia de la Cruz Ruiz, María Jesús Rodríguez‐Palero, Peter Askjaer, Marta Artal‐Sanz   +3 more
openalex   +1 more source

Modified cytoskeletal and extracellular matrix composition in the canine testis after long‐acting gonadotropin‐releasing hormone agonist deslorelin treatment

Andrology, EarlyView.
Abstract Background Long‐acting gonadotropin‐releasing hormone (GnRH) agonists are commonly used for fertility control in male dogs. Their effect on testicular histomorphology has not been clarified. Objectives To elucidate the mechanisms underlying androgen withdrawal in response to long‐acting GnRH agonist deslorelin 4.7 mg treatment on testicular ...
Aykut Gram, Murat Abay, Duygu Yaman Gram, Narin Liman, Linda Müller, Orsolya Balogh   +5 more
wiley   +1 more source

CFDP1 regulates the stability of pericentric heterochromatin thereby affecting RAN GTPase activity and mitotic spindle formation.

PLoS Biology
The densely packed centromeric heterochromatin at minor and major satellites is comprised of H3K9me2/3 histones, the heterochromatin protein HP1α, and histone variants.
Gokul Gopinathan, Qian Xu, Xianghong Luan, Thomas G H Diekwisch   +3 more
doaj   +1 more source

A heterochromatin-dependent transcription machinery drives piRNA expression

Nature, 2017
Nuclear small RNA pathways safeguard genome integrity by establishing transcription-repressing heterochromatin at transposable elements. This inevitably also targets the transposon-rich source loci of the small RNAs themselves.
P. R. Andersen, László Tirián, Milica Vunjak, J. Brennecke   +3 more
semanticscholar   +1 more source

Non‐canonical nitric oxide signalling and DNA methylation: Inflammation induced epigenetic alterations and potential drug targets

British Journal of Pharmacology, EarlyView.
Abstract DNA methylation controls DNA accessibility to transcription factors and other regulatory proteins, thereby affecting gene expression and hence cellular identity and function. As epigenetic modifications control the transcriptome, epigenetic dysfunction is strongly associated with pathological conditions and ageing.
Christopher H. Switzer
wiley   +1 more source

MeCP2 dependent heterochromatin reorganization during neural differentiation of a novel Mecp2-deficient embryonic stem cell reporter line.

PLoS ONE, 2012
The X-linked Mecp2 is a known interpreter of epigenetic information and mutated in Rett syndrome, a complex neurological disease. MeCP2 recruits HDAC complexes to chromatin thereby modulating gene expression and, importantly regulates higher order ...
Bianca Bertulat, Maria Luigia De Bonis, Floriana Della Ragione, Anne Lehmkuhl, Manuela Milden, Christian Storm, K Laurence Jost, Simona Scala, Brian Hendrich, Maurizio D'Esposito, M Cristina Cardoso   +10 more
doaj   +1 more source

Pervasive SUMOylation of heterochromatin and piRNA pathway proteins [PDF]

, 2022
Maria Ninova, Hannah Holmes, Brett Lomenick, Katalin Fejes Tóth, Alexei A. Aravin   +4 more
openalex   +1 more source

Integration of epigenetics into ecotoxicology: insights and fundamental research needs

Biological Reviews, EarlyView.
ABSTRACT Epigenetics refers to heritable changes in genome function that occur without direct alterations to the DNA sequence. A multitude of environmental contaminants can influence the epigenetic marks of a genome. Changes of epigenetic marks including DNA methylation, histone modifications, and non‐coding RNAs can induce alterations at the gene ...
Albano Pinto, Jana Asselman, Patrícia Pereira, Joana Luísa Pereira   +3 more
wiley   +1 more source

Fission yeast Caprin protein is required for efficient heterochromatin establishment.

PLoS Genetics
Heterochromatin is a key feature of eukaryotic genomes that serves important regulatory and structural roles in regions such as centromeres. In fission yeast, maintenance of existing heterochromatic domains relies on positive feedback loops involving ...
Haidao Zhang, Ekaterina Kapitonova, Adriana Orrego, Christos Spanos, Joanna Strachan, Elizabeth H Bayne   +5 more
doaj   +1 more source