Results 101 to 110 of about 124,493 (360)
The architecture of chicken chromosome territories changes during differentiation [PDF]
, 2004 BACKGROUND: Between cell divisions the chromatin fiber of each chromosome is restricted to a subvolume of the interphase cell nucleus called chromosome territory.
Bonifer, C. +7 more
core +4 more sources
RNAi and Heterochromatin Assembly [PDF]
Cold Spring Harbor Perspectives in Biology, 2015 The involvement of RNA interference (RNAi) in heterochromatin formation has become clear largely through studies in the fission yeast Schizosaccharomyces pombe and plants like Arabidopsis thaliana. This article discusses how heterochromatic small interfering RNAs are produced and how the RNAi machinery participates in the formation and function of ...
Danesh Moazed, Robert A. Martienssen
openaire +2 more sources
PRC1‐Mediated H2Aub Loop Formation and Function in Arabidopsis
Advanced Science, EarlyView.In the Arabidopsis genome, H2Aub and H3K27me3 marks do not always co‐localize, and some regions are marked exclusively by H2Aub. By using Capture‐Hi‐C, it is found that H2Aub loops are preferentially established between two H2Aub enriched regions.
Lingxiao Luo +8 more
wiley +1 more source
Epigenetic Chromatin Silencing: Bistability and Front Propagation
, 2007 The role of post-translational modification of histones in eukaryotic gene regulation is well recognized. Epigenetic silencing of genes via heritable chromatin modifications plays a major role in cell fate specification in higher organisms.
Alberts B +13 more
core +1 more source
Advanced Science, EarlyView.In Arabidopsis, the homeostasis of full‐ and hemi‐methylation is mainly regulated by maintenance methylation. The maintenance methylation at hemi‐methylated dyads is highly efficient but the efficiency differs at euchromatic or heterochromatic regions. Nucleosomes impair the hemi‐ to full‐methylation transition. Lagged methylation maintenance after DNA
Hengye Chen, Chenhuan Xu
wiley +1 more source
Constitutive heterochromatin controls nuclear mechanics, morphology, and integrity through H3K9me3 mediated chromocenter compaction. [PDF]
NucleusAberrant nuclear morphology is a hallmark of human disease and causes nuclear dysfunction. Perturbed nuclear mechanics via reduced heterochromatin weakens the nucleus resulting in nuclear blebbing and rupture.
Manning G +4 more
europepmc +2 more sources
Emerging roles of telomeric chromatin alterations in cancer [PDF]
, 2019 Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria +2 more
core +1 more source
HP1a-mediated heterochromatin formation inhibits high dietary sugar-induced tumor progression
Cell Death and Disease, 2021 High dietary sugar (HDS) is a modern dietary concern that involves excessive consumption of carbohydrates and added sugars, and increases the risk of metabolic disorders and associated cancers.
Che-Wei Chang +2 more
doaj +1 more source
Advanced Science, EarlyView.This study presents telomere‐to‐telomere genome assemblies for two populations of Larimichthys crocea. We identified centromere‐specific tandem repeats invaded by LTR/ERV1 retrotransposons, unique 5S rRNA enrichment patterns, and population‐specific structural variants. Comparative genomic analyses further reveal distinct adaptive mechanisms in the MYD
Yu Cui +9 more
wiley +1 more source
The HSV-1 Latency-Associated Transcript Functions to Repress Latent Phase Lytic Gene Expression and Suppress Virus Reactivation from Latently Infected Neurons [PDF]
, 2016 open access articleHerpes simplex virus 1 (HSV-1) establishes life-long latent infection within sensory neurons, during which viral lytic gene expression is silenced.
Coleman, Heather M. +7 more
core +3 more sources