Results 101 to 110 of about 73,923 (265)
Genetics and Molecular Biology, 1998 We describe the karyotypes of eight bee species of the genus Melipona and compare them in terms of heterochromatin content and location (C-banding technique).
Marla Piumbini Rocha +1 more
doaj +1 more source
RepeatOBserver: Tandem Repeat Visualisation and Putative Centromere Detection
Molecular Ecology Resources, EarlyView.ABSTRACT Tandem repeats play an important role in centromere structure, subtelomeric regions, DNA methylation, recombination and the regulation of gene activity. Analysis of their distribution in genomes offers a potential means for predicting putative centromere locations, which continues to be a challenge for genome annotation.
Cassandra Elphinstone +3 more
wiley +1 more source
Epigenetics & Chromatin, 2009 Background Position-effect variegation (PEV) is the stochastic transcriptional silencing of a gene positioned adjacent to heterochromatin. white-mottled X-chromosomal inversions in Drosophila are classic PEV models that show variegation of the eye color ...
Vogel Maartje J +5 more
doaj +1 more source
Properties of Chromatin in Human Cells as Characteristics of the State of Human Organism: A Review [PDF]
Adv Complement Alt Med. 1(1). ACAM.000505. 2018.
http://crimsonpublishers.com/acam/volume1-issue1-acam.php, 2018 The state of chromatin in individual cells is directly related to the state of the whole organism and may be used for assessment of the state of the whole organism. Many hereditary diseases are connected with chromatin rearrangements. Chromatin distribution in cell nucleus is an important characteristic which may be applied for determination of disease
arxiv
Targeting CRM1 for Progeria Syndrome Therapy
Aging Cell, EarlyView.Pharmacological inhibition of CRM1 mediated by selinexor, the first‐in‐class selective inhibitor of CRM1, mitigates the senescent phenotype of Hutchinson‐Gilford progeria syndrome (HGPS) patients‐derived primary fibroblasts. Treatment of HGPS fibroblasts with selinexor promotes the clearances of progerin via autophagy activation, restores the ...
Adriana Soto‐Ponce +14 more
wiley +1 more source
Integrative genomics analysis identifies pericentromeric regions of human chromosomes affecting patterns of inter-chromosomal interactions [PDF]
arXiv, 2014 Genome-wide analysis of distributions of densities of long-range interactions of human chromosomes with each other, nucleoli, nuclear lamina, and binding sites of chromatin state regulatory proteins, CTCF and STAT1, identifies non-random highly correlated patterns of density distributions along the chromosome length for all these features.
arxiv
A heterochromatin-dependent transcription machinery drives piRNA expression
Nature, 2017 Nuclear small RNA pathways safeguard genome integrity by establishing transcription-repressing heterochromatin at transposable elements. This inevitably also targets the transposon-rich source loci of the small RNAs themselves.
P. R. Andersen +3 more
semanticscholar +1 more source
Aging Cell, EarlyView.This study demonstrates that reducing the enzyme topoisomerase Top2 or its mammalian homolog TOP2B promotes longevity across multiple species, including yeast, worms, and mice. At the cellular/molecular level, TOP2B reduction mitigates the major cellular aging hallmarks such as epigenetic alterations, cell senescence, lysosomal biogenesis, and ...
Man Zhu +12 more
wiley +1 more source
The cell proliferation antigen Ki-67 organises heterochromatin
eLife, 2016 Antigen Ki-67 is a nuclear protein expressed in proliferating mammalian cells. It is widely used in cancer histopathology but its functions remain unclear. Here, we show that Ki-67 controls heterochromatin organisation.
M. Sobecki +20 more
semanticscholar +1 more source
Aging Cell, EarlyView.Direct activation and rejuvenation of aged fibroblasts through the application of mechanical forces in a 3D spheroid culture model. The ERK signaling pathway was revealed as a key underlying mechanism. ABSTRACT Age‐related changes in human dermal fibroblasts (HDFs) contribute to impaired wound healing and skin aging.
Hui Liu +4 more
wiley +1 more source