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The Cell Biology of Heterochromatin
Cells, 2022 A conserved feature of virtually all higher eukaryotes is that the centromeres are embedded in heterochromatin. Here we provide evidence that this tight association between pericentric heterochromatin and the centromere is essential for proper metaphase ...
Brandt Warecki, William Sullivan
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Heterochromatin in plant meiosis
NucleusHeterochromatin is an organizational property of eukaryotic chromosomes, characterized by extensive DNA and histone modifications, that is associated with the silencing of transposable elements and repetitive sequences.
Cong Wang +3 more
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Establishment and evolution of heterochromatin [PDF]
Annals of the New York Academy of Sciences, 2020 AbstractThe eukaryotic genome is packaged into transcriptionally active euchromatin and silent heterochromatin, with most studies focused on the former encompassing the majority of protein‐coding genes. The recent development of various sequencing techniques has refined this classic dichromatic partition and has better illuminated the composition ...
Jing Liu +5 more
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Heterochromatin and nucleic acid
Agricultural and Food Science, 1948 Heterokromaattisiksi tämän käsitteen laajimmassa merkityksessä on nimitetty kromosominosia, jotka spiraloitumiseensa ja värjäytyväisyyteensä nähden jossain tuman vaiheessa eroavat muista, eukromaattisista kromosominosista. Heterokromatiini, sen rakenne ja toiminta, ovat erikoisesti viimeisen kymmenen vuoden aikana olleet vilkkaan tutkimuksen kohteena ...
Eeva Therman-Suomalainen
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Heterochromatin: silence is golden [PDF]
Current Biology, 2003 Epigenetically heritable heterochromatin domains control a variety of chromosomal functions. In addition to stable repression of large pericentric and telomeric domains, heterochromatin plays an essential role in the maintenance of genomic integrity through its role in sister chromatin cohesion and chromosome segregation.
Shiv I. S. Grewal, Sarah C. R. Elgin
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Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrity [PDF]
, 2011 Genomic maps of chromatin modifications have provided evidence for the partitioning of genomes into domains of distinct chromatin states, which assist coordinated gene regulation.
Hair, A. +3 more
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Maternal depletion of Piwi, a component of the RNAi system, impacts heterochromatin formation in Drosophila. [PDF]
PLoS Genetics, 2013 A persistent question in epigenetics is how heterochromatin is targeted for assembly at specific domains, and how that chromatin state is faithfully transmitted.
Tingting Gu, Sarah C R Elgin
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PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina
Nucleus, 2023 The eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located at the nuclear periphery.
Anna A. Kiseleva +4 more
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Heterochromatin: Guardian of the Genome [PDF]
Annual Review of Cell and Developmental Biology, 2018 Constitutive heterochromatin is a major component of the eukaryotic nucleus and is essential for the maintenance of genome stability. Highly concentrated at pericentromeric and telomeric domains, heterochromatin is riddled with repetitive sequences and has evolved specific ways to compartmentalize, silence, and repair repeats.
Janssen, Aniek +2 more
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DNA Double-Strand Break Repair: All Roads Lead to HeterochROMAtin Marks
Frontiers in Genetics, 2021 In response to DNA double-strand breaks (DSBs), chromatin modifications orchestrate DNA repair pathways thus safeguarding genome integrity. Recent studies have uncovered a key role for heterochromatin marks and associated factors in shaping DSB repair ...
Pierre Caron +2 more
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