Results 11 to 20 of about 73,923 (265)
Constitutive Heterochromatin in Eukaryotic Genomes: A Mine of Transposable Elements
Cells, 2022 Transposable elements (TEs) are abundant components of constitutive heterochromatin of the most diverse evolutionarily distant organisms. TEs enrichment in constitutive heterochromatin was originally described in the model organism Drosophila ...
René Massimiliano Marsano +1 more
doaj +1 more source
The proper splicing of RNAi factors is critical for pericentric heterochromatin assembly in fission yeast. [PDF]
PLoS Genetics, 2014 Heterochromatin preferentially assembles at repetitive DNA elements, playing roles in transcriptional silencing, recombination suppression, and chromosome segregation.
Scott P Kallgren +8 more
doaj +1 more source
DNA Double-Strand Break Repair: All Roads Lead to HeterochROMAtin Marks
Frontiers in Genetics, 2021 In response to DNA double-strand breaks (DSBs), chromatin modifications orchestrate DNA repair pathways thus safeguarding genome integrity. Recent studies have uncovered a key role for heterochromatin marks and associated factors in shaping DSB repair ...
Pierre Caron +2 more
doaj +1 more source
Different behaviour of C-banded peri-centromeric heterochromatin between sex chromosomes and autosomes in Polyphagan beetles [PDF]
Comparative Cytogenetics, 2019 Heterochromatin variation was studied after C-banding of male karyotypes with a XY sex formula from 224 species belonging to most of the main families of Coleoptera.
Anne-Marie Dutrillaux +1 more
doaj +3 more sources
SIRT3 consolidates heterochromatin and counteracts senescence
Nucleic Acids Research, 2021 Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase linked to a broad range of physiological and pathological processes, including aging and aging-related diseases. However, the role of SIRT3 in regulating human stem cell homeostasis remains unclear. Here
Zhiqing Diao +15 more
semanticscholar +1 more source
Maternal depletion of Piwi, a component of the RNAi system, impacts heterochromatin formation in Drosophila. [PDF]
PLoS Genetics, 2013 A persistent question in epigenetics is how heterochromatin is targeted for assembly at specific domains, and how that chromatin state is faithfully transmitted.
Tingting Gu, Sarah C R Elgin
doaj +1 more source
PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina
Nucleus, 2023 The eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located at the nuclear periphery.
Anna A. Kiseleva +4 more
doaj +1 more source
Journal of Applied Toxicology, Volume 43, Issue 1, Page 66-88, January 2023., 2023 Abstract Nowadays, more and more attention has been focused on the risk of the neurotoxic action of cadmium (Cd) under environmental exposure. Due to the growing incidence of nervous system diseases, including neurodegenerative changes, and suggested involvement of Cd in their aetiopathogenesis, this review aimed to discuss critically this element ...
Agnieszka Ruczaj +1 more
wiley +1 more source
Stem Cell Research & Therapy, 2020 Background Stem cell senescence has been proposed as one of the major drivers of aging, and MSC senescence contributes to aging-related diseases. Activation of mTORC1 pathway and heterochromatin organization have been characterized as two characteristics
Hailong Liu +7 more
doaj +1 more source
Rbm10 facilitates heterochromatin assembly via the Clr6 HDAC complex
Epigenetics & Chromatin, 2021 Splicing factors have recently been shown to be involved in heterochromatin formation, but their role in controlling heterochromatin structure and function remains poorly understood.
Martina Weigt +7 more
doaj +1 more source