Results 11 to 20 of about 133,661 (356)
Global regulation of heterochromatin spreading by Leo1 [PDF]
Open Biology, 2015 Heterochromatin plays important roles in eukaryotic genome regulation. However, the repressive nature of heterochromatin combined with its propensity to self-propagate necessitates robust mechanisms to contain heterochromatin within defined boundaries ...
Laure Verrier +6 more
doaj +1 more source
53BP1 regulates heterochromatin through liquid phase separation
Nature Communications, 2022 Human 53BP1 is primarily known as a key player in regulating DNA double strand break (DSB) repair choice; however, its involvement in other biological process is less well understood.
Lei Zhang +18 more
semanticscholar +1 more source
Constitutive Heterochromatin in Eukaryotic Genomes: A Mine of Transposable Elements
Cells, 2022 Transposable elements (TEs) are abundant components of constitutive heterochromatin of the most diverse evolutionarily distant organisms. TEs enrichment in constitutive heterochromatin was originally described in the model organism Drosophila ...
René Massimiliano Marsano +1 more
doaj +1 more source
The proper splicing of RNAi factors is critical for pericentric heterochromatin assembly in fission yeast. [PDF]
PLoS Genetics, 2014 Heterochromatin preferentially assembles at repetitive DNA elements, playing roles in transcriptional silencing, recombination suppression, and chromosome segregation.
Scott P Kallgren +8 more
doaj +1 more source
Different behaviour of C-banded peri-centromeric heterochromatin between sex chromosomes and autosomes in Polyphagan beetles [PDF]
Comparative Cytogenetics, 2019 Heterochromatin variation was studied after C-banding of male karyotypes with a XY sex formula from 224 species belonging to most of the main families of Coleoptera.
Anne-Marie Dutrillaux +1 more
doaj +3 more sources
Heterochromatin: silence is golden [PDF]
Current Biology, 2003 Epigenetically heritable heterochromatin domains control a variety of chromosomal functions. In addition to stable repression of large pericentric and telomeric domains, heterochromatin plays an essential role in the maintenance of genomic integrity through its role in sister chromatin cohesion and chromosome segregation.
Shiv I. S. Grewal, Sarah C. R. Elgin
openaire +3 more sources
Cell Research, 2022 Loss of heterochromatin has been implicated as a cause of pre-mature aging and age-associated decline in organ functions in mammals; however, the specific cell types and gene loci affected by this type of epigenetic change have remained unclear.
Yanxiao Zhang +10 more
semanticscholar +1 more source
DNA Double-Strand Break Repair: All Roads Lead to HeterochROMAtin Marks
Frontiers in Genetics, 2021 In response to DNA double-strand breaks (DSBs), chromatin modifications orchestrate DNA repair pathways thus safeguarding genome integrity. Recent studies have uncovered a key role for heterochromatin marks and associated factors in shaping DSB repair ...
Pierre Caron +2 more
doaj +1 more source
SIRT3 consolidates heterochromatin and counteracts senescence
Nucleic Acids Research, 2021 Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase linked to a broad range of physiological and pathological processes, including aging and aging-related diseases. However, the role of SIRT3 in regulating human stem cell homeostasis remains unclear. Here
Zhiqing Diao +15 more
semanticscholar +1 more source
Pericentromeric heterochromatin is hierarchically organized and spatially contacts H3K9me2 islands in euchromatin. [PDF]
, 2020 Membraneless pericentromeric heterochromatin (PCH) domains play vital roles in chromosome dynamics and genome stability. However, our current understanding of 3D genome organization does not include PCH domains because of technical challenges associated ...
Acevedo, David +7 more
core +2 more sources