Results 41 to 50 of about 124,493 (360)

Negative Regulators of an RNAi-Heterochromatin Positive Feedback Loop Safeguard Somatic Genome Integrity in Tetrahymena

Cell Reports, 2017
RNAi-mediated positive feedback loops are pivotal for the maintenance of heterochromatin, but how they are downregulated at heterochromatin-euchromatin borders is not well understood.
Jan H. Suhren, Tomoko Noto, Kensuke Kataoka, Shan Gao, Yifan Liu, Kazufumi Mochizuki   +5 more
doaj   +1 more source

Forced expression of MSR repeat transcripts above a threshold limit breaks heterochromatin organisation. [PDF]

Nat Commun
Mouse heterochromatin is characterised by transcriptionally competent major satellite repeat (MSR) sequences and it has been proposed that MSR RNA contributes to the integrity of heterochromatin.
Ching RW, Świst-Rosowska KM, Erikson G, Koschorz B, Engist B, Jenuwein T.   +5 more
europepmc   +2 more sources

The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken [PDF]

, 2005
The replacement histone H2A.Z is variously reported as being linked to gene expression and preventing the spread of heterochromatin in yeast, or concentrated at heterochromatin in mammals.
Bonifer, C., Bruce, K., Crane-Robinson, C., Greaves, I., Lefevre, P., Mantouvalou, E., Myers, F.A., Thorne, A.W., Tremethick, D.J.   +8 more
core   +5 more sources

HP1 reshapes the nucleosome core to promote phase separation of heterochromatin

Nature, 2019
Heterochromatin affects genome function at many levels. It enables heritable gene repression, maintains chromosome integrity and provides mechanical rigidity to the nucleus1,2.
S. Sanulli, Michael J. Trnka, V. Dharmarajan, Ryan W. Tibble, B. Pascal, A. Burlingame, P. Griffin, J. Gross, G. Narlikar   +8 more
semanticscholar   +1 more source

Dense Transposon Integration Reveals Essential Cleavage and Polyadenylation Factors Promote Heterochromatin Formation

Cell Reports, 2020
Summary: Heterochromatin functions as a scaffold for factors responsible for gene silencing and chromosome segregation. Heterochromatin can be assembled by multiple pathways, including RNAi and RNA surveillance.
Si Young Lee, Stevephen Hung, Caroline Esnault, Rakesh Pathak, Kory R. Johnson, Oluwadamilola Bankole, Akira Yamashita, Hongen Zhang, Henry L. Levin   +8 more
doaj   +1 more source

Sex Differences in Drosophila melanogaster Heterochromatin Are Regulated by Non-Sex Specific Factors. [PDF]

PLoS ONE, 2015
The eukaryotic genome is assembled into distinct types of chromatin. Gene-rich euchromatin has active chromatin marks, while heterochromatin is gene-poor and enriched for silencing marks.
Manasi S Apte, Victoria H Meller
doaj   +1 more source

ATXR5 and ATXR6 are H3K27 monomethyltransferases required for chromatin structure and gene silencing. [PDF]

, 2009
Constitutive heterochromatin in Arabidopsis thaliana is marked by repressive chromatin modifications, including DNA methylation, histone H3 dimethylation at Lys9 (H3K9me2) and monomethylation at Lys27 (H3K27me1).
Bernatavichute, Yana V, Cokus, Shawn, Feng, Suhua, Jacob, Yannick, Jacobsen, Steven E, Johnson, Lianna M, LeBlanc, Chantal A, Michaels, Scott D, Pellegrini, Matteo, Stroud, Hume   +9 more
core   +1 more source

Regulation of ectopic heterochromatin-mediated epigenetic diversification by the JmjC family protein Epe1.

PLoS Genetics, 2019
H3K9 methylation (H3K9me) is a conserved marker of heterochromatin, a transcriptionally silent chromatin structure. Knowledge of the mechanisms for regulating heterochromatin distribution is limited.
Masato Sorida, Takahiro Hirauchi, Hiroaki Ishizaki, Wataru Kaito, Atsushi Shimada, Chie Mori, Yuji Chikashige, Yasushi Hiraoka, Yutaka Suzuki, Yasuyuki Ohkawa, Hiroaki Kato, Shinya Takahata, Yota Murakami   +12 more
doaj   +1 more source

Mediator directs co-transcriptional heterochromatin assembly by RNA interference-dependent and -independent pathways. [PDF]

PLoS Genetics, 2013
Heterochromatin at the pericentromeric repeats in fission yeast is assembled and spread by an RNAi-dependent mechanism, which is coupled with the transcription of non-coding RNA from the repeats by RNA polymerase II. In addition, Rrp6, a component of the
Eriko Oya, Hiroaki Kato, Yuji Chikashige, Chihiro Tsutsumi, Yasushi Hiraoka, Yota Murakami   +5 more
doaj   +1 more source

A simulation model of heterochromatin formation at submolecular detail

iScience, 2022
Summary: Heterochromatin is a physical state of the chromatin fiber that maintains gene repression during cell development. Although evidence exists on molecular mechanisms involved in heterochromatin formation, a detailed structural mechanism of ...
Michael R. Williams, Yan Xiaokang, Nathaniel A. Hathaway, Dmitri Kireev   +3 more
doaj   +1 more source