Results 41 to 50 of about 85,707 (260)

The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic

eLife, 2016
Heterochromatin is enriched for specific epigenetic factors including Heterochromatin Protein 1a (HP1a), and is essential for many organismal functions.
Joel M Swenson, Serafin U Colmenares, Amy R Strom, Sylvain V Costes, Gary H Karpen   +4 more
doaj   +1 more source

Heterochromatin: Guardian of the Genome.

Annual Review of Cell and Developmental Biology, 2018
Constitutive heterochromatin is a major component of the eukaryotic nucleus and is essential for the maintenance of genome stability. Highly concentrated at pericentromeric and telomeric domains, heterochromatin is riddled with repetitive sequences and ...
A. Janssen, Serafin U. Colmenares, G. Karpen   +2 more
semanticscholar   +1 more source

Histone H4 lysine 12 acetylation regulates telomeric heterochromatin plasticity in Saccharomyces cerevisiae. [PDF]

PLoS Genetics, 2011
Recent studies have established that the highly condensed and transcriptionally silent heterochromatic domains in budding yeast are virtually dynamic structures. The underlying mechanisms for heterochromatin dynamics, however, remain obscure.
Bo O Zhou, Shan-Shan Wang, Yang Zhang, Xiao-Hong Fu, Wei Dang, Brian A Lenzmeier, Jin-Qiu Zhou   +6 more
doaj   +1 more source

Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes

Nucleic Acids Research, 2019
The eukaryotic genome is functionally organized into domains of transcriptionally active euchromatin and domains of highly compact transcriptionally silent heterochromatin.
R. J. Roach, M. Garavís, C. González, G. Jameson, V. Filichev, T. Hale   +5 more
semanticscholar   +1 more source

Ring-like distribution of constitutive heterochromatin in bovine senescent cells. [PDF]

PLoS ONE, 2011
BACKGROUND: Cells that reach "Hayflick limit" of proliferation, known as senescent cells, possess a particular type of nuclear architecture. Human senescent cells are characterized by the presence of highly condensed senescent associated heterochromatin ...
Andrey Pichugin, Nathalie Beaujean, Xavier Vignon, Yegor Vassetzky   +3 more
doaj   +1 more source

SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer

Protein & Cell, 2020
SIRT7, a sirtuin family member implicated in aging and disease, is a regulator of metabolism and stress responses. It remains elusive how human somatic stem cell populations might be impacted by SIRT7. Here, we found that SIRT7 expression declines during
Shijia Bi, Zunpeng Liu, Zeming Wu, Zehua Wang, Xiaoqian Liu, Si Wang, Jie Ren, Yan Yao, Weiqi Zhang, Moshi Song, Guang-Hui Liu, J. Qu   +11 more
semanticscholar   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3

Nature Cell Biology, 2020
Following fertilization in mammals, the gametes are reprogrammed to create a totipotent zygote, a process that involves de novo establishment of chromatin domains.
Adam Burton, V. Brochard, Carmen Galán, Elias R. Ruiz-Morales, Q. Rovira, Diego Rodriguez-Terrones, Kai Kruse, Stéphanie Le Gras, Vishnu S. Udayakumar, H. Chin, André Eid, Xiaoyu Liu, Chenfei Wang, Shaorong Gao, S. Pradhan, Juan M. Vaquerizas, N. Beaujean, T. Jenuwein, M. Torres-Padilla   +18 more
semanticscholar   +1 more source

A Modular and Customizable CRISPR/Cas Toolkit for Epigenome Editing of Cis‐regulatory Modules

Advanced Science, EarlyView.
Epigenome editing surpasses genome editing in gene regulation. Modular epigenome editing frameworks are developed to interrogate cis‐regulome, enabling tunable reprogramming of cis‐elements, uncovering their epigenetic responsiveness and cross‐species portability.
Lingrui Zhang, Jianxin Fu, Tiandan Long, Chao Zhang, Fuhua Fan, Zhaobo Lang, Jian‐Kang Zhu   +6 more
wiley   +1 more source

Heterochromatin in plant meiosis

Nucleus
Heterochromatin is an organizational property of eukaryotic chromosomes, characterized by extensive DNA and histone modifications, that is associated with the silencing of transposable elements and repetitive sequences.
Cong Wang, Zhiyu Chen, Gregory P. Copenhaver, Yingxiang Wang   +3 more
doaj   +1 more source