Results 41 to 50 of about 73,923 (265)
Brain Pathology, Volume 33, Issue 1, January 2023., 2023 Schematic depicting characterization of pathological tau signatures and nuclear alterations in neurons, astrocytes and microglia in neurodegenerative diseases. Abstract Accumulation of pathological tau aggregates is a prominent feature in tauopathies that leads during the course of the diseases to neuronal dysfunction before and cell death after ...
Mauro Montalbano +4 more
wiley +1 more source
The basal level of gene expression associated with chromatin loosening shapes Waddington landscapes and controls cell differentiation [PDF]
J. Mol. Biol. 432 (2020) 2253-2270, 2020 The baseline level of transcription, which is variable and difficult to quantify, seriously complicates the normalization of comparative transcriptomic data, but its biological importance remains unappreciated. We show that this currently neglected ingredient is essential for controlling gene network multistability and therefore cellular ...
arxiv +1 more source
A model of dynamic stability of H3K9me3 heterochromatin to explain the resistance to reprogramming of differentiated cells [PDF]
Biochim Biophys Acta. Gene Regulatory Mechanisms 2017
Feb;1860(2):184-195, 2017 Despite their dynamic nature, certain chromatin marks must be maintained over the long term. This is particulary true for histone 3 lysine 9 (H3K9) trimethylation, that is involved in the maintenance of healthy differentiated cellular states by preventing inappropriate gene expression, and has been recently identified as the most efficient barrier to ...
arxiv +1 more source
A maximum-entropy model to predict 3D structural ensembles of chromatins from pairwise distances: Applications to Interphase Chromosomes and Structural Variants [PDF]
, 2022 The principles that govern the organization of genomes, which are needed for a deeper understanding of how chromosomes are packaged and function in eukaryotic cells, could be deciphered if the three-dimensional (3D) structures are known. Recently, single-cell imaging experiments have determined the 3D coordinates of a number of loci in a chromosome ...
arxiv +1 more source
SETDB1 regulates microtubule dynamics
Cell Proliferation, Volume 55, Issue 12, December 2022., 2022 SETDB1 association with microtubules inhibits microtubule polymerization and enhances their instability. SETDB1 may affect the microtubules by interacting with HDAC6 to enhance HDAC6 tubulin deacetylation activity. Abstract Objectives SETDB1 is a methyltransferase responsible for the methylation of histone H3‐lysine‐9, which is mainly related to ...
Rosari Hernandez‐Vicens +4 more
wiley +1 more source
The cAMP signaling pathway regulates Epe1 protein levels and heterochromatin assembly.
PLoS Genetics, 2022 The epigenetic landscape of a cell frequently changes in response to fluctuations in nutrient levels, but the mechanistic link is not well understood.
Kehan Bao +11 more
doaj +1 more source
Microbiology Spectrum, 2023 The survival of malaria parasites in the changing human blood environment largely depends on their ability to alter gene expression by epigenetic mechanisms.
Lucas Michel-Todó +6 more
doaj +1 more source
SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer
Protein & Cell, 2020 SIRT7, a sirtuin family member implicated in aging and disease, is a regulator of metabolism and stress responses. It remains elusive how human somatic stem cell populations might be impacted by SIRT7. Here, we found that SIRT7 expression declines during
Shijia Bi +11 more
semanticscholar +1 more source
How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance
Cells, 2020 Heterochromatin Protein 1 (HP1) is a highly conserved protein that has been used as a classic marker for heterochromatin. HP1 binds to di- and tri-methylated histone H3K9 and regulates heterochromatin formation, functions and structure.
Raquel Sales-Gil, Paola Vagnarelli
doaj +1 more source
Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes
Nucleic Acids Research, 2019 The eukaryotic genome is functionally organized into domains of transcriptionally active euchromatin and domains of highly compact transcriptionally silent heterochromatin.
R. J. Roach +5 more
semanticscholar +1 more source