Results 91 to 100 of about 42,305 (289)

Recent advances in the electrochemical construction of heterocycles

Beilstein Journal of Organic Chemistry, 2014
Due to the fact that the major portion of pharmaceuticals and agrochemicals contains heterocyclic units and since the overall number of commercially used heterocyclic compounds is steadily growing, heterocyclic chemistry remains in the focus of the ...
Robert Francke
doaj   +1 more source

One-step synthesis of pyridines and dihydropyridines in a continuous flow microwave reactor [PDF]

, 2013
The Bohlmann–Rahtz pyridine synthesis and the Hantzsch dihydropyridine synthesis can be carried out in a microwave flow reactor or using a conductive heating flow platform for the continuous processing of material. In the Bohlmann–Rahtz reaction, the use
Bagley, Mark C, Fusillo, Vincenzo, Jenkins, Robert L, Lubinu, M Caterina, Mason, Christopher   +4 more
core   +2 more sources

CRISPR/Cas9‐Based Vanadium MXene‐Free Radical Spatiotemporally Controlled Nanoreactor for Photothermal‐Induced Multi‐Effect Synergistic Antitumor Therapy

Advanced Science, EarlyView.
In this study, a MXene‐based V4C3 nanoplatform, VARH, was constructed, which achieved a photothermal conversion efficiency of 44.21% in the NIR‐II window. This platform integrated photothermal therapy, chemodynamic therapy, and thermodynamic therapy with CRISPR/Cas9‐mediated heat shock protein 90 knock‐out technology.
Zi‐Jian Huang, Feng‐Ming Li, Yi‐Fan Tu, Ke‐Ke Feng, Cheng‐Lei Li, Shi‐Cheng Tian, Yong‐Shan Hu, Jing‐Wei Shao, Zhen‐Hua Liu   +8 more
wiley   +1 more source

(Z)-2-[Methoxy(phenyl)methylidene]-3,4,5-trimethyl-2,3-dihydro-1,3-thiazole

Acta Crystallographica Section E, 2012
In the title compound, C14H17NOS, the plane defined by the bridging methylene C atom and its three substituents makes dihedral angles of 14.37 (8)° with the heterocycle and 26.17 (8)° with the phenyl ring, while the ...
Biplab Maji, Herbert Mayr, Peter Mayer
doaj   +1 more source

Modular Generation of Alkyl Selenyl Radicals for the Synthesis of Alkyl Selenides via a Mechanochemical Approach

Advanced Science, EarlyView.
We present a mechanochemical, radical‐mediated hydroselenation of alkenes under ambient conditions. This method modularly generates alkyl selenyl radicals from elemental selenium and alkyl (pseudo)halides, utilizing PhSiH3 and H2O as hydrogen atom donors, with the water likely originating from the air and/or trace water present in the reagents ...
Xiaochun He, Yu Zhou, Fei Zhou, Zixi Ai, Peiyu Hu, Xuemei Zhang, Xiaofeng Wei, Gui‐Juan Cheng, Zhong Lian   +8 more
wiley   +1 more source

Study of different heterocycles showing significant anti-severe acute respiratory syndrome 2 activity in vitro and in vivo [PDF]

Veterinary World
Background and Aim: With the emergence of severe acute respiratory syndrome-related coronavirus (SARS-CoV-2), antiviral drug development has gained increased significance due to the high incidence and potentially severe complications of the resulting ...
Aleksandr Yengoyan, Tiruhi Gomktsyan, Vergush Pivazyan, Emma Ghazaryan, Roza Shainova, Armen Karapetyan, Diana Avetyan, Levon Aslanyan, Karine Baroyan, Alexander Tuzikov, Mariam Sargsyan, Bagrat Baghdasaryan, Nane Bayramyan, Sona Hakobyan, Arpine Poghosyan, Aida Avetisyan, Hranush Avagyan, Lina Hakobyan, Karalyan Zaven   +18 more
doaj   +1 more source

Enhancing the cellular uptake of Py–Im polyamides through next-generation aryl turns [PDF]

, 2012
Pyrrole–imidazole (Py–Im) hairpin polyamides are a class of programmable, sequence-specific DNA binding oligomers capable of disrupting protein–DNA interactions and modulating gene expression in living cells.
Baird, Belitsky, Best, Bijsterbosch, Bradford, Chenoweth, Chenoweth, Chenoweth, Cleutjens, Cohen, Crowley, David C. Montgomery, Dervan, Dervan, Dickinson, Dose, D’Adamio, Edelson, Edwards, Gissot, Herman, Hesselberth, Hsu, Hsu, Jacobs, Johnson, Jordan L. Meier, Krutzik, Kwon, Magee, Mapp, Matsuda, Meijsing, Mrksich, Muzikar, Nickols, Nickols, Nickols, Nishijima, Ohtsukia, Olenyuk, Peter B. Dervan, Poulin-Kerstien, Reddy, Riegman, Rucker, Schmidt, Schultz, So, Swalley, Tsai, Van Dyke, Vaquerizas, Vichai, Yao   +54 more
core   +2 more sources

Biomimetic Polymerization of Tellurocysteine: Breaking the Natural Amino Acid Radioprotection Limitation

Advanced Science, EarlyView.
Inspired by natural amino acid polymer‐melanin systems, this study strategically incorporated tellurocysteine to develop advanced radiation‐shielding materials. This approach transformed the primary interaction mechanism between melanin‐based materials and incident photons from Compton scattering to the photoelectric effect. Tellurocysteine‐polymerized
Wei Chen, Hanjie Zhu, Yue Zhang, Yuqing Qiao, Ruotong Deng, Huaping Xu, Wei Cao   +6 more
wiley   +1 more source

FeCoNiCuPt High‐Entropy Alloy Boosts Photocatalytic Hydrogen Production on Protonated Graphitic Carbon Nitride

Advanced Science, EarlyView.
In this study, FeCoNiCuPt high‐entropy alloy particles (HEA) are loaded onto protonated g‐C3N4 nanosheets (HCN NSs) to construct HEA/HCN composites through an electrostatic self‐assembly method. Protonation treatment enriches the surface of g‐C3N4 nanosheets with abundant active sites and enhances their interfacial charge separation capability ...
Yunzhu Zang, Jiali Ren, Yanjun Xue, Jian Tian   +3 more
wiley   +1 more source

Asymmetric Synthesis of 1-Heteroaryl-1-arylalkyl Tertiary Alcohols and 1-Pyridyl-1-arylethanes by Lithiation-Borylation Methodology [PDF]

, 2013
The synthesis of highly enantioenriched alpha-heterocyclic tertiary alcohols has been achieved via lithiation-borylation of a configurationally stable lithiated carbamate and heterocyclic pinacol boronic esters followed by oxidation. Protodeboronation of
Aggarwal V. K., Biradar D. B., Biradar D. B., Carstens A., Charlotte G. Watson, Chen C.-A., Cozzi P. G., Dosa P. I., García C., García C., García C., Garg D. C., Greene M. A., Hatano M., Hatano M., Hatano M., Hoppe D., Hu Q., Kanai M., Luderer M. R., Madduri A. V. R., Madduri A. V. R., Maity P., Matsunaga N., Messaoudi S., Moree W. J., Nave S., Ou L., Pathak T. P., Ramón D. J., Ramón D. J., Shi S.-L, Shibasaki M., Song S., Starck J. P., Stymiest J. L., Taylor B. L. H., Varinder K. Aggarwal, Wada R., Weber B., Yus M., Yus M.   +41 more
core   +3 more sources