Results 101 to 110 of about 128,452 (331)

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

Triggering redox activity in a thiophene compound: radical stabilization and coordination chemistry [PDF]

, 2006
The synthesis, metalation, and redox properties of an acyclic bis(iminothienyl)methene L− are presented. This π-conjugated anion displays pronounced redox activity, undergoing facile one-electron oxidation to the acyclic, metal-free, neutral radical L ...
Davison, Gray, Gray, Schrauzer, Eisenberg, Sproules, Lyons, Kaim, Krężel, Jacquet, Huang, Broere, Greenhalgh, Luca, Munhá, Lyaskovskyy, Praneeth, Kaim, Chirik, Chirik, Annibale, Pankhurst, Pankhurst, Kochem, Reddy, Schweyen, Yoshida, Tanaka, Claessens, Hennessy, Loudet, Kaszyński, Chatterjee, Rasmussen, Gopalakrishna, Wakamiya, Tabakovic, d'Oro, Singh, Kawase, Davenport, Kia, Chen, Doshi, Latos-Grazynski, Lucas, Lane   +46 more
core   +2 more sources

In Situ Lipoprotein‐seeking Dye for in Vivo Real‐Time Imaging of Lipid Dysregulation Diseases

Advanced Science, EarlyView.
This study develops lipoprotein‐seeking NIR‐II dyes that specifically bind circulating lipoproteins. These dyes form ultra‐stable complexes with endogenous lipoprotein, enabling real‐time, high‐contrast imaging of fatty liver and atherosclerotic plaques. Tunable binding kinetics allow customized imaging windows.
Yijing Du, Zetao Dang, Baofeng Xu, Jiajun Xu, Dan Wang, Yuewei Zhang, Shoujun Zhu   +6 more
wiley   +1 more source

Synthetic utility and reactivity of N-alkynylazoles [PDF]

, 2015
textThe chemistry of N-alkynylazoles is a newly emerging area of chemistry with particular interest in heterocycle synthesis. Synthetic preparations of this class of molecule have shown an increasing presence in literature, however, the synthetic ...
Gilbreath, Bradford Lynd
core  

A Blood‐Brain Barrier‐Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting Aβ42‐Induced Oxidative Stress

Advanced Science, EarlyView.
The newly designed metallo‐corrole (Mor‐Cor)Ag(III) with a morpholino group exhibited promising therapeutic potential for Alzheimer's disease. It significantly reduces reactive oxygen species (ROS), decreases GFAP expression, increases neurite length, and decreases cell death compared to other similar metallo‐corroles. Abstract Alzheimer's disease (AD)
Arup Tarai, Tuhina Mitra, Tanmoy Pain, Jyotiprakash Mallick, Rwiddhi Chakraborty, Kallam Tejaswi, Swagata Ghatak, Sanjib Kar   +7 more
wiley   +1 more source

Low Catalyst Loadings in Olefin Metathesis: Synthesis of Nitrogen Heterocycles by Ring-Closing Metathesis [PDF]

, 2010
A series of ruthenium catalysts have been screened under ring-closing metathesis (RCM) conditions to produce five-, six-, and seven-membered carbamate-protected cyclic amines. Many of these catalysts demonstrated excellent RCM activity and yields with as
Champagne, Timothy M., Grubbs, Robert H., Hong, Soon Hyeok, Kuhn, Kevin M., Lee, Choon Woo, Nickel, Andrew, Pederson, Richard L., Virgil, Scott C., Wei, Wen-Hao   +8 more
core   +2 more sources

Cathode Electrolyte Interphase Engineering by Quaternized Chitosan for Stabilized Li–SPAN Batteries

Advanced Science, EarlyView.
In this work, quaternized chitosan (QCS) is reported as an additive optimizing the sulfurized polyacrylonitrile (SPAN) cathode/electrolyte interphase (CEI). Its high positive charge density adsorbs PF6− anions, enriching the Helmholtz layer with aggregates. This promotes rapid anion desolvation, forming an anion‐derived CEI enriched in LiF.
Runhe He, Hao Liu, Qing Gao, Dong Cai, Kuikui Xiao, Yinhang Zhang, Xinmin Zhang, Xianyang Cheng, Yuhui Wang, Lixing Kang, Huagui Nie, Yatao Liu, Zhi Yang   +12 more
wiley   +1 more source

Comprehensive Organic Analysis of Antartic Micrometeorites [PDF]

, 2008
Introduction: Micrometeorites (MMs) are thought to be significant contributors of organic material to the early Earth [1], and a variety of techniques have been employed to identify their organic composition [2-6]. These include the identification of key
Dobrica, E., Gilmour, I., Pearson, V. K., Turner, D. C., Wilson, R. C.   +4 more
core  

Triplet Energy Transfer‐Driven Intermolecular [2+2] Photocycloaddition of Acyclic Imines and Indoles: Facile Access to Azetidine‐Fused Indolines

Advanced Science, EarlyView.
An intermolecular aza‐Paternò‐Büchi reaction of indoles and acyclic imines is enabled by visible‐light‐driven triplet energy transfer, providing azetidine‐fused indolines up to 93% yield for 30 examples and providing a novel protocol to access previously inaccessible scaffolds. ABSTRACT Currently, successful examples of the aza‐[2+2] photocycloaddition
Gang Yang, Zeng Han, Hong Zhang, Xiuling Cui   +3 more
wiley   +1 more source

An Overview of Saturated Cyclic Ethers: Biological Profiles and Synthetic Strategies

Molecules, 2019
Saturated oxygen heterocycles are widely found in a broad array of natural products and other biologically active molecules. In medicinal chemistry, small and medium rings are also important synthetic intermediates since they can undergo ring-opening and
Qili Lu, Dipesh S. Harmalkar, Yongseok Choi, Kyeong Lee   +3 more
doaj   +1 more source