Results 101 to 110 of about 3,130,844 (307)

ForestPMPlot: A Flexible Tool for Visualizing Heterogeneity Between Studies in Meta-analysis. [PDF]

, 2016
Meta-analysis has become a popular tool for genetic association studies to combine different genetic studies. A key challenge in meta-analysis is heterogeneity, or the differences in effect sizes between studies.
Eskin, Eleazar, Han, Buhm, Kang, Eun Yong, Li, Xiao, Park, Yurang, Segrè, Ayellet V   +5 more
core   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Ageing and personal retirement savings plan participation with heterogeneity in preferences: The Portuguese case [PDF]

, 2007
This paper analyses the relationship between ageing and personal retirement savings plan participation in the Portuguese population, taking into account heterogeneity and endogeneity in preferences. A mixed logit model is used to analyse the determinants
Barros, CP, Caporale, GM, Garcia, MTM
core  

Induction of AML cell differentiation using HOXA9/DNA binding inhibitors as a potential therapeutic option for HOXA9‐dependent AML

HemaSphere
The mainstay of acute myeloid leukemia (AML) treatment still relies on traditional chemotherapy, with a survival rate of approximately 30% for patients under 65 years of age and as low as 5% for those beyond.
Mélanie Lambert, Samy Jambon, Mohamed A. Bouhlel, Sabine Depauw, Julie Vrevin, Samuel Blanck, Guillemette Marot, Martin Figeac, Claude Preudhomme, Bruno Quesnel, David W. Boykin, Marie‐Hélène David‐Cordonnier   +11 more
doaj   +1 more source

Biallelic Inactivation of NSD1 Associated With Carcinogenesis in Sotos Syndrome

Pediatric Blood &Cancer, EarlyView.
Nicholas A. Borja, Anuja Sule, Katie Ann McMullen, Aditi Dhir, Matthew D. Hall, Heather J. McCrea, Sakir Humayun Gultekin, Mustafa Tekin, Bradley Gampel   +8 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Evolutionary Prisoner's Dilemma on heterogeneous Newman-Watts small-world network

, 2007
We focus on the heterogeneity of social networks and its role to the emergence of prevailing cooperation and sustaining cooperators. The social networks are representative of the interaction relationships between players and their encounters in each ...
Abramson, Albert, Anghel, Axelrod, Barabási, Challet, F. Fu, Kirley, L. Wang, L.-H. Liu, Newman, Newman, Nishikawa, Nowak, Nowak, Ohtsuki, Santos, Santos, Santos, Santos, Szabó, Szabó, Szolnoki, Tang, Tomassini, Vukov, Watts, Zimmermann   +27 more
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The macroscopic effects of microscopic heterogeneity

, 2012
Over the past decade, advances in super-resolution microscopy and particle-based modeling have driven an intense interest in investigating spatial heterogeneity at the level of single molecules in cells.
Aleksic, Andrews, Andrews, Aoki, Asakura, Bancaud, Banks, Berg, Betzig, Bray, Bray, Burack, Bénichou, Chevalier, Dard, Duke, Eggeling, Ellis, Ferrell, Ferrell, Gerland, Golding, Gopalakrishnan, Govern, Gowers, Grecco, Gurry, Hancock, Hattne, Hell, Howard, Hu, Huang, Kalay, Kholodenko, Kinkhabwala, Kolch, Koshland, Kusumi, Kusumi, Kusumi, Lagerholm, Li, Lingwood, Lis, Locasale, Lomholt, Lommerse, Lutkenhaus, Machta, Markevich, Mello, Miller, Monod, Morelli, Mugler, Murakoshi, Muramatsu, Nash, Oh, Pike, Plimpton, Plowman, Prior, Redner, Rust, Sauro, Simons, Sourjik, Sourjik, Stanford, Takahashi, Tian, Tkačik, Valitutti, van Albada, van Zon, van Zon, Wartlick, Weiss, Wofsy, Zhao, Zimmerman, Zimmerman   +83 more
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source