Results 11 to 20 of about 3,130,844 (307)

Mitochondrial Heterogeneity [PDF]

Frontiers in Genetics, 2019
Cell-to-cell heterogeneity drives a range of (patho)physiologically important phenomena, such as cell fate and chemotherapeutic resistance. The role of metabolism, and particularly mitochondria, is increasingly being recognised as an important explanatory factor in cell-to-cell heterogeneity.
Juvid Aryaman, Juvid Aryaman, Juvid Aryaman, Iain G. Johnston, Iain G. Johnston, Nick S. Jones, Nick S. Jones   +6 more
openaire   +6 more sources

How Lineage Tracing Studies Can Unveil Tumor Heterogeneity in Breast Cancer

Biomedicines, 2021
Lineage tracing studies have become a well-suited approach to reveal cellular hierarchies and tumor heterogeneity. Cellular heterogeneity, particularly in breast cancer, is still one of the main concerns regarding tumor progression and resistance to anti-
Elena Vinuesa-Pitarch, Daniel Ortega-Álvarez, Verónica Rodilla   +2 more
doaj   +1 more source

Vimentin Promotes the Aggressiveness of Triple Negative Breast Cancer Cells Surviving Chemotherapeutic Treatment

Cells, 2021
Tremendous data have been accumulated in the effort to understand chemoresistance of triple negative breast cancer (TNBC). However, modifications in cancer cells surviving combined and sequential treatment still remain poorly described. In order to mimic
Marie Winter, Samuel Meignan, Pamela Völkel, Pierre-Olivier Angrand, Valérie Chopin, Nadège Bidan, Robert-Alain Toillon, Eric Adriaenssens, Chann Lagadec, Xuefen Le Bourhis   +9 more
doaj   +1 more source

Direct interaction of TrkA/CD44v3 is essential for NGF-promoted aggressiveness of breast cancer cells

Journal of Experimental & Clinical Cancer Research, 2022
Background CD44 is a multifunctional membrane glycoprotein. Through its heparan sulfate chain, CD44 presents growth factors to their receptors. We have shown that CD44 and Tropomyosin kinase A (TrkA) form a complex following nerve growth factor (NGF ...
Sarah Trouvilliez, Julien Cicero, Romain Lévêque, Léo Aubert, Cyril Corbet, Alexandre Van Outryve, Karolin Streule, Pierre-Olivier Angrand, Pamela Völkel, Romain Magnez, Guillaume Brysbaert, Caroline Mysiorek, Fabien Gosselet, Roland Bourette, Eric Adriaenssens, Xavier Thuru, Chann Lagadec, Jérôme de Ruyck, Véronique Orian-Rousseau, Xuefen Le Bourhis, Robert-Alain Toillon   +20 more
doaj   +1 more source

Heterogeneous Agglomeration [PDF]

Review of Economics and Statistics, 2017
Many prior treatments of agglomeration explicitly or implicitly assume that all industries agglomerate for the same reasons. This paper uses UK establishment-level coagglomeration data to document substantial heterogeneity across industries in the microfoundations of agglomeration economies.
Faggio, Giulia, Silva, Olmo, Strange, William C.   +2 more
openaire   +6 more sources

Feed‐forward loops between metastatic cancer cells and their microenvironment—the stage of escalation

EMBO Molecular Medicine, 2022
Breast cancer is the most frequent cancer among women, and metastases in distant organs are the leading cause of the cancer‐related deaths. While survival of early‐stage breast cancer patients has increased dramatically, the 5‐year survival rate of ...
Zora Baumann, Priska Auf der Maur, Mohamed Bentires‐Alj   +2 more
doaj   +1 more source

Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish

Cells, 2021
Polycomb repressive complex 2 (PRC2) mediates histone H3K27me3 methylation and the stable transcriptional repression of a number of gene expression programs involved in the control of cellular identity during development and differentiation.
Ludivine Raby, Pamela Völkel, Shaghayegh Hasanpour, Julien Cicero, Robert-Alain Toillon, Eric Adriaenssens, Isabelle Van Seuningen, Xuefen Le Bourhis, Pierre-Olivier Angrand   +8 more
doaj   +1 more source

Heterogeneous convergence [PDF]

Economics Letters, 2007
We use US county-level data to estimate convergence rates for 22 individual states. We find significant heterogeneity. E.g., the California estimate is 19.9% and the New York estimate is 3.3%. Convergence rates are essentially uncorrelated with income levels.
Young, Andrew, Higgins, Matthew, Levy, Daniel   +2 more
openaire   +11 more sources

miR-92a-3p regulates cisplatin-induced cancer cell death

Cell Death and Disease, 2023
Non-small cell lung cancer is characterized by a dismal prognosis largely owing to inefficient diagnosis and tenacious drug resistance. Therefore, the identification of new molecular determinants underlying sensitivity of cancer cells to existing therapy
Romain Larrue, Sandy Fellah, Nihad Boukrout, Corentin De Sousa, Julie Lemaire, Carolane Leboeuf, Marine Goujon, Michael Perrais, Bernard Mari, Christelle Cauffiez, Nicolas Pottier, Cynthia Van der Hauwaert   +11 more
doaj   +1 more source

Lipopolysaccharide-binding protein expression is associated to the metastatic status of osteosarcoma patients

Journal of Bone Oncology, 2022
Osteosarcoma (OS) is a rare malignant primary bone tumours characterized by a high genetic and cell composition heterogeneity. Unfortunately, despite the use of drug combinations and the recent development of immunotherapies, the overall survival has not
Clément J.F. Heymann, Christine Bobin-Dubigeon, Javier Muñoz-Garcia, Denis Cochonneau, Emilie Ollivier, Marie-Françoise Heymann, Dominique Heymann   +6 more
doaj   +1 more source