Results 41 to 50 of about 1,436,185 (319)

A coregulatory influence map of glioblastoma heterogeneity and plasticity

npj Precision Oncology
We present GBM-cRegMap, an online resource providing a comprehensive coregulatory influence network perspective on glioblastoma (GBM) heterogeneity and plasticity.
Chloé Bernhard, Konstantinos Geles, Geoffrey Pawlak, Wajdi Dhifli, Aurélien Dispot, Jules Dusol, Maria Kondratova, Sophie Martin, Mélissa Messé, Damien Reita, David Tulasne, Isabelle Van Seuningen, Natacha Entz-Werle, Silvia Anna Ciafrè, Monique Dontenwill, Mohamed Elati   +15 more
doaj   +1 more source

Heterogeneous algebras

Journal of Combinatorial Theory, 1970
AbstractMany of the basic theorems about general “algebras” derived in [1, Ch. 6] are extended to a class of heterogeneous algebras which includes automata, state machines, and monoids acting on sets. It is shown that some algebras can be fruitfully studied, using different interpretations, both as (homogeneous) algebras and as heterogeneous algebras ...
Birkhoff, Garrett, Lipson, John D.
openaire   +1 more source

Exercise Interventions in Children, Adolescents and Young Adults With Paediatric Bone Tumours—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Bone tumours present significant challenges for affected patients, as multimodal therapy often leads to prolonged physical limitations. This is particularly critical during childhood and adolescence, as it can negatively impact physiological development and psychosocial resilience.
Jennifer Queisser, Claire Laurie, Teresa Schmidt, Irene von Luettichau, Peter Bekkering, Sabine Kesting   +5 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Technical report: liquid overlay technique allows the generation of homogeneous osteosarcoma, glioblastoma, lung and prostate adenocarcinoma spheroids that can be used for drug cytotoxicity measurements

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: The mechanisms involved in cancer initiation, progression, drug resistance, and disease recurrence are traditionally investigated through in vitro adherent monolayer (2D) cell models.
Camille Jubelin, Camille Jubelin, Camille Jubelin, Javier Muñoz-Garcia, Javier Muñoz-Garcia, Denis Cochonneau, Emilie Ollivier, François Vallette, François Vallette, Marie-Françoise Heymann, Marie-Françoise Heymann, Lisa Oliver, Lisa Oliver, Dominique Heymann, Dominique Heymann, Dominique Heymann   +15 more
doaj   +1 more source

Heterogeneous Catalysis [PDF]

Angewandte Chemie International Edition, 2015
AbstractA heterogeneous catalyst is a functional material that continually creates active sites with its reactants under reaction conditions. These sites change the rates of chemical reactions of the reactants localized on them without changing the thermodynamic equilibrium between the materials.
openaire   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells

Experimental Hematology & Oncology, 2023
Background Triple-Negative Breast Cancer is particularly aggressive, and its metastasis to the brain has a significant psychological impact on patients' quality of life, in addition to reducing survival.
Julien Cicero, Sarah Trouvilliez, Martine Palma, Gaetan Ternier, Laurine Decoster, Eloise Happernegg, Nicolas Barois, Alexandre Van Outryve, Lucie Dehouck, Roland P. Bourette, Eric Adriaenssens, Chann Lagadec, Cagatay Mehmet Tarhan, Dominique Collard, Zied Souguir, Elodie Vandenhaute, Grégory Maubon, François Sipieter, Nicolas Borghi, Fumitaka Shimizu, Takashi Kanda, Paolo Giacobini, Fabien Gosselet, Nathalie Maubon, Xuefen Le Bourhis, Isabelle Van Seuningen, Caroline Mysiorek, Robert-Alain Toillon   +27 more
doaj   +1 more source

Engineering of a Bispecific Nanofitin with Immune Checkpoint Inhibitory Activity Conditioned by the Cross-Arm Binding to EGFR and PDL1

Biomolecules, 2023
Re-education of the tumor microenvironment with immune checkpoint inhibitors (ICI) has provided the most significant advancement in cancer management, with impressive efficacy and durable response reported.
Perrine Jacquot, Javier Muñoz-Garcia, Maurine Fleury, Denis Cochonneau, Rémi Gaussin, Elise Enouf, Caroline Roze, Emilie Ollivier, Mathieu Cinier, Dominique Heymann   +9 more
doaj   +1 more source

Heterogeneity of heterogeneities in neuronal networks [PDF]

Frontiers in Computational Neuroscience, 2014
Neurons in the brain exhibit a broad spectrum of heterogeneities even within a given morphological or physiological class. In a recent modeling study, Mejias and Longtin investigated the effects of heterogeneity in the voltage threshold for spike generation on the dynamics of random networks of excitatory and inhibitory neurons (Mejias and Longtin ...
Fabiano eBaroni, Fabiano eBaroni, Fabiano eBaroni, Alberto eMazzoni   +3 more
openaire   +4 more sources