Results 61 to 70 of about 1,436,185 (319)

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

2O Dissecting intratumoral heterogeneity in localized HR+/HER2- breast cancer using single-cell DNA sequencing (scDNA-seq) [PDF]

, 2023
D.T.N. Tran, A. Tran Dien, Luigi Cerbone, B. Verret, Nathalie Droin, Véronique Scott, I.J. Garberis, A. Sauvadet, M. Francillette, Bruna Leite, J-Y. Scoazec, C. Ayadi, C. Machavoine, V. Camara‐Clayette, Fabrice André   +14 more
openalex   +1 more source

Heterogeneous voter models [PDF]

Physical Review E, 2010
We introduce the heterogeneous voter model (HVM), in which each agent has its own intrinsic rate to change state, reflective of the heterogeneity of real people, and the partisan voter model (PVM), in which each agent has an innate and fixed preference for one of two possible opinion states.
Masuda, Naoki, Gibert, N., Redner, S.
openaire   +3 more sources

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Long non-coding RNA UCA1 modulates SMARCA2-containing SWI/SNF chromatin remodeling complexes in human colorectal cancer

iScience
Summary: Differential long non-coding RNA (lncRNA) expression has been correlated to clinical characteristics of colorectal cancers (CRCs), which are the second leading cause of cancer-related deaths.
Bernadette Neve, Elsa Hadj Bachir, Belinda Duchêne, Mouloud Souidi, Martin Figeac, Jean-Pascal Meneboo, Emmanuelle Leteurtre, Nicolas Jonckheere, Audrey Vincent, Isabelle Van Seuningen, Christophe Mariette, Guillaume Piessen, François Corfiotti, Clarisse Eveno, François-René Pruvot, Stéphanie Truant, Mehdi El Amrani, Emmanuelle Leteurtre, Florence Renaud, Viviane Gnemmi, Laurence Wicquart, Fabienne Escande, Julie Leclerc, Sonia Paget, Soumaya El Moghrabi, Audrey Vincent, Isabelle Van Seuningen   +26 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Emerging roles of MITF as a crucial regulator of immunity

Experimental and Molecular Medicine
Microphthalmia-associated transcription factor (MITF), a basic helix-loop-helix leucine zipper transcription factor (bHLH-Zip), has been identified as a melanocyte-specific transcription factor and plays a critical role in melanocyte survival ...
Aram Lee, Jihyun Lim, Jong-Seok Lim
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source