Results 71 to 80 of about 3,130,844 (307)

The Efficacy and Safety of Bevacizumab/Irinotecan/Temozolomide (BIT) for Relapsed/Refractory Neuroblastoma: The UK Children's Cancer and Leukaemia Group Experience

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Patients with high‐risk neuroblastoma who either are refractory to induction chemotherapy or relapse following multi‐modal treatment have a dismal prognosis. Based on data from the BEACON trial, since 2021 the UK national guidelines recommend bevacizumab, irinotecan, and temozolomide (BIT) for patients with relapsed/refractory ...
Thomas J. Jackson, Menna Shamma, Upeka Senanayake, Shaimaa Sahmoud, Kathleen Duffin, Victoria Howard, David King, Ayesha Fathani, Blanche Lumb, Andrei Pobischan, Irum Latif Memon, Monzir Ahmed, Rhian Thomas, Gerard Millen, Yasmeen Alomari, Sucheta Vaidya, Lynley V. Marshall, Sally L. George, Ramya Ramanujachar, Juliet Gray, Paola Angelini   +20 more
wiley   +1 more source

Individual heterogeneity generates explosive system network dynamics

, 2017
Individual heterogeneity is a key characteristic of many real-world systems, from organisms to humans. However its role in determining the system's collective dynamics is typically not well understood.
Johnson, Neil F., Manrique, Pedro D.
core   +1 more source

Technical report: liquid overlay technique allows the generation of homogeneous osteosarcoma, glioblastoma, lung and prostate adenocarcinoma spheroids that can be used for drug cytotoxicity measurements

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: The mechanisms involved in cancer initiation, progression, drug resistance, and disease recurrence are traditionally investigated through in vitro adherent monolayer (2D) cell models.
Camille Jubelin, Camille Jubelin, Camille Jubelin, Javier Muñoz-Garcia, Javier Muñoz-Garcia, Denis Cochonneau, Emilie Ollivier, François Vallette, François Vallette, Marie-Françoise Heymann, Marie-Françoise Heymann, Lisa Oliver, Lisa Oliver, Dominique Heymann, Dominique Heymann, Dominique Heymann   +15 more
doaj   +1 more source

Heterogeneous Catalysis [PDF]

Angewandte Chemie International Edition, 2015
AbstractA heterogeneous catalyst is a functional material that continually creates active sites with its reactants under reaction conditions. These sites change the rates of chemical reactions of the reactants localized on them without changing the thermodynamic equilibrium between the materials.
openaire   +3 more sources

Treatment Decision‐Making Roles and Preferences Among Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Decision‐making (DM) dynamics between adolescents and young adults (AYAs) with cancer, parents, and oncologists remain underexplored in diverse populations. We examined cancer treatment DM preferences among an ethnically and socioeconomically diverse group of AYAs and their parents.
Amanda M. Gutierrez, Jill O. Robinson, Wendy A. Allen‐Rhoades, Hadley S. Smith, Isabel Canfield, Rebecca L. Hsu, Sarah R. Scollon, Lauren R. Desrosiers‐Battu, Nicole M. Schneider, Frank Y. Lin, Donald Williams Parsons, Sharon E. Plon, Mary A. Majumder, Janet Malek, Amy L. McGuire   +14 more
wiley   +1 more source

Lipid Metabolism and Resistance to Anticancer Treatment

Biology, 2020
Metabolic reprogramming is crucial to respond to cancer cell requirements during tumor development. In the last decade, metabolic alterations have been shown to modulate cancer cells’ sensitivity to chemotherapeutic agents including conventional and ...
Nicolas Germain, Mélanie Dhayer, Marie Boileau, Quentin Fovez, Jerome Kluza, Philippe Marchetti   +5 more
doaj   +1 more source

ProNGF promotes brain metastasis through TrkA/EphA2 induced Src activation in triple negative breast cancer cells

Experimental Hematology & Oncology, 2023
Background Triple-Negative Breast Cancer is particularly aggressive, and its metastasis to the brain has a significant psychological impact on patients' quality of life, in addition to reducing survival.
Julien Cicero, Sarah Trouvilliez, Martine Palma, Gaetan Ternier, Laurine Decoster, Eloise Happernegg, Nicolas Barois, Alexandre Van Outryve, Lucie Dehouck, Roland P. Bourette, Eric Adriaenssens, Chann Lagadec, Cagatay Mehmet Tarhan, Dominique Collard, Zied Souguir, Elodie Vandenhaute, Grégory Maubon, François Sipieter, Nicolas Borghi, Fumitaka Shimizu, Takashi Kanda, Paolo Giacobini, Fabien Gosselet, Nathalie Maubon, Xuefen Le Bourhis, Isabelle Van Seuningen, Caroline Mysiorek, Robert-Alain Toillon   +27 more
doaj   +1 more source

Engineering of a Bispecific Nanofitin with Immune Checkpoint Inhibitory Activity Conditioned by the Cross-Arm Binding to EGFR and PDL1

Biomolecules, 2023
Re-education of the tumor microenvironment with immune checkpoint inhibitors (ICI) has provided the most significant advancement in cancer management, with impressive efficacy and durable response reported.
Perrine Jacquot, Javier Muñoz-Garcia, Maurine Fleury, Denis Cochonneau, Rémi Gaussin, Elise Enouf, Caroline Roze, Emilie Ollivier, Mathieu Cinier, Dominique Heymann   +9 more
doaj   +1 more source

Heterogeneity of heterogeneities in neuronal networks [PDF]

Frontiers in Computational Neuroscience, 2014
Neurons in the brain exhibit a broad spectrum of heterogeneities even within a given morphological or physiological class. In a recent modeling study, Mejias and Longtin investigated the effects of heterogeneity in the voltage threshold for spike generation on the dynamics of random networks of excitatory and inhibitory neurons (Mejias and Longtin ...
Fabiano eBaroni, Fabiano eBaroni, Fabiano eBaroni, Alberto eMazzoni   +3 more
openaire   +4 more sources

Persistence time of SIS infections in heterogeneous populations and networks [PDF]

, 2017
For a susceptible-infectious-susceptible (SIS) infection model in a heterogeneous population, we present simple formulae giving the leading-order asymptotic (large population) behaviour of the mean persistence time, from an endemic state to extinction of
Clancy, Damian
core   +2 more sources