An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi +5 more
wiley +1 more source
Durability of COVID-19 vaccine-induced immunity in Saudi Arabia: evidence, gaps, and implications for Hajj and mass-gathering preparedness. [PDF]
Azhar LE +6 more
europepmc +1 more source
Subversion of Atypical Mucin Traps by a Spore‐Coat Effector Blocks Cellular Immunity in Drosophila
While the entomopathogenic fungus Metarhizium robertsii can evade insect humoral immunity, its subversion of cellular defenses is still elusive. We identify Eac1 as a spore‐coat protein essential for infecting drosophilids by targeting atypical mucins (Sgf1 and Sgf2), which can entrap spores in a gel matrix and thereby facilitate hemocyte encapsulation.
Shiqin Li +7 more
wiley +1 more source
Immunization with a multisubunit vaccine induces immunological memory and cross-protective immunity against heterologous <i>Chlamydia</i> serovars. [PDF]
Medhavi F +5 more
europepmc +1 more source
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun +7 more
wiley +1 more source
Differential functional immune recall across homologous and heterologous COVID-19 vaccination regimens. [PDF]
Che-Kamaruddin N +7 more
europepmc +1 more source
ABSTRACT Synthetic biology has recently proven to be a valuable tool for enhancing agriculture even in the face of environmental and biological stresses. Understanding the challenges that militate synthetic biology will assist in ensuring safe, stable, and scalable crop production.
Ben Jesuorsemwen Enagbonma +6 more
wiley +1 more source
Cross‐Neutralizing and Broadly Neutralizing Human Antibodies Against Nonenveloped Viruses
In this review article, Marchand et al. compare cross ‐ and broadly ‐neutralizing human antibodies against non ‐ enveloped viruses from several major families, discussing their structural characteristics, neutralization mechanisms and relevance for the development of antiviral vaccines and therapeutics.
Sarah Marchand +2 more
wiley +1 more source
Nasal Nanoparticle Vaccine Induces a Cross-Strain T-Cell Immunity Against <i>Toxoplasma gondii</i>. [PDF]
Lecouffe A +8 more
europepmc +1 more source
Trained Immunity in Host Defense: Mechanisms, Pathogen Interactions, and Therapeutic Potential. [PDF]
Siddiqui F +5 more
europepmc +1 more source

