Results 191 to 200 of about 48,636 (248)
Entering the Age of Specificity in T Cell Immunity
ABSTRACT The discovery of MHC restriction, the resolution of peptide–MHC structure, and the identification of the T cell receptor gene quickly centered epitope‐level specificity as a core concern of T cell biology. Epitope mapping culminated in functional peptide‐based stimulation assays and tetramer staining, which together provide exquisite ...
Paul G. Thomas
wiley +1 more source
Systemic and Mucosal Immune Responses From Serotype-Switched Viral-Vectored Ebola Vaccines. [PDF]
Wiggins J, Madapong A, Weaver E.
europepmc +1 more source
ABSTRACT Photobacteriosis is a major threat to marine aquaculture, and the siderophore transporter FrpA represents a promising target for effective subunit vaccine development. In this study, we evaluated Montanide GEL 02 PR and phosphatidylcholine‐based liposomes as aqueous and safer alternatives to Freund's adjuvant for an FrpA‐based subunit vaccine ...
Marta A. Lages +7 more
wiley +1 more source
ABSTRACT Outbreaks of vibriosis caused by Vibrio anguillarum are a persistent constraint on rainbow trout (Oncorhynchus mykiss) aquaculture. However, information on the population structure of field strains in Turkey has been lacking. Here, we report the first systematic serotypic, proteomic, and genomic characterization of 23 V.
Soner Altun +10 more
wiley +1 more source
Swine Group A rotavirus vaccines: current status, adjuvant strategies, challenges, and future perspectives. [PDF]
Zhen Z +5 more
europepmc +1 more source
Plant phosphate (Pi) homeostasis relies on coordinated activities of the inositol polyphosphate kinases IPK1 and ITPK1, which balance localized InsP7 biosynthesis to control COP9 signalosome (CSN)‐dependent deneddylation of cullin 1 (CUL1). Perturbation of this equilibrium affects the stability of SPX4, a key negative regulator of phosphate starvation ...
Yashika Walia +12 more
wiley +1 more source
Csi‐miR3954b targets CsCE70 and CsPLA1, promoting the synthesis of phenolic acids and flavonoids, thereby enhancing citrus resistance to postharvest green mould. ABSTRACT Green mould is one of the major postharvest diseases affecting citrus. Although evidence indicates that microRNAs (miRNAs) participate in plant defence responses, their roles and ...
Jixin Tian +7 more
wiley +1 more source
Cuscuta reflexa infection sites. Summary Cuscuta species are holoparasitic plants that penetrate host stems with haustoria, connect to the vasculature and exhaust water, nutrients and carbohydrates. Parasite seedlings possess only limited maternal reserves and the development of a vascular connection takes several days.
Maleen Hartenstein +10 more
wiley +1 more source
Dual-antigen AdV5 vaccines against Crimean-Congo hemorrhagic fever virus induce superior humoral and Th1-biased cellular immunity. [PDF]
Hanifehnezhad A +12 more
europepmc +1 more source
Potyvirus turnip mosaic virus induces neutral lipid accumulation and lipid droplet biogenesis in infected leaves for its own benefit. See also the Commentary on this article by May & Nagy, 252: 525–527. Summary Lipid droplets (LDs), which are dedicated to storing neutral lipids (NLs), are dynamic organelles involved in numerous other functions ...
Léna Jambou +16 more
wiley +1 more source

