Study on the heteroresistance of carbapenem-resistant Klebsiella pneumoniae to Tigecycline and Polymyxin B and antibacterial activity of combined drugs in vitro [PDF]
BMC MicrobiologyBackground Antimicrobial resistance is a global concern. Tigecycline (TGC) and polymyxin B (PMB) constitute some of the last treatment options remaining for carbapenem-resistant Klebsiella pneumoniae (CRKP).
Yulan Dong +4 more
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An investigation of gene dosage reveals that increased sensitivity to D-cycloserine divergently impacts the transience of heteroresistance in Escherichia coli [PDF]
mBioHeteroresistance describes the phenomenon where seemingly isogenic bacterial populations contain subpopulations with elevated resistance compared to the susceptible majority that are often missed in routine susceptibility testing. The enhanced resistance
Katherine J. Sniezek, Mark P. Brynildsen
doaj +2 more sources
Deletions of recombination genes impair tandem amplification and reshape heteroresistance mechanisms in Escherichia coli [PDF]
mBioHeteroresistance is a transient resistance phenotype characterized by the presence of small subpopulations of bacterial cells with elevated antibiotic resistance within a susceptible main population.
Sheida Heidarian +3 more
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Characterization of Mycobacterium tuberculosis heteroresistance by genotyping
International Journal of Mycobacteriology, 2020 Background: Heteroresistance is the coexistence of susceptible and resistant strains in the same individual, considered the preliminary step for total resistance, and can stem from mixed infection or clonal heterogeneity.
Lida Jouca de Assis Figueredo +6 more
doaj +3 more sources
Screening for heterogeneous drug resistance in tuberculosis and its impact on clinical prognosis: A comprehensive review [PDF]
iScienceSummary: Tuberculosis (TB) remains a leading global health threat, with the rise of drug-resistant (DR-TB) strains posing a significant impediment to disease control.
Xiaoyun Du +3 more
doaj +2 more sources
Bacteremia caused by staphylococci with inducible vancomycin heteroresistance [PDF]
Clinical Infectious Diseases, 1999 The clinical significance of bacteremia due to vancomycin- heteroresistant staphylococci and a rapid laboratory screening method were examined; 203 strains of staphylococci isolated from patients with clinically significant bacteremia were screened by ...
Ho, PL, Wong, SSY, Woo, PCY, Yuen, KY
core +5 more sources
Mixed infections and heteroresistance of Mycobacterium tuberculosis among multidrug-resistant tuberculosis in China: a genomic epidemiology study [PDF]
Emerging Microbes and InfectionsMixed infection refers to the presence of multiple Mycobacterium tuberculosis strains within one host, while heteroresistance denotes the coexistence of drug-susceptible and drug-resistant strains or genotypes.
Yanping Liu +18 more
doaj +2 more sources
Investigation of Colistin Heteroresistance and Some Factors Affecting Heteroresistance in Carbapenem-Resistant A. baumannii Strains [PDF]
Mediterranean Journal of Infection, Microbes and Antimicrobials, 2017 Introduction: Colistin can be used in patients infected with carbapenem-resistant Acinetobacter baumannii complex (CR-ABC), but recently resistance to colistin and heteroresistance have been reported.
Deniz GAZEL, Müşerref TATMAN OTKUN
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Plasmid pHXY0908 confers ciprofloxacin heteroresistance to Salmonella enterica serovar typhimurium ATCC 14028 by regulating efflux pump gene expression [PDF]
BMC MicrobiologyBackground Salmonella enterica Serovar Typhimurium (S. Typhimurium) is a major global foodborne pathogen. In our previous study, the S. Typhimurium ATCC 14028 strain harboring plasmid pHXY0908 survived at fourfold its ciprofloxacin MIC (MIC0908 = 0.125 ...
Mengyuan Li +10 more
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MexS mediated heteroresistance of Pseudomonas aeruginosa to ciprofloxacin [PDF]
Frontiers in MicrobiologyBacterial heteroresistance has been increasingly identified as an important phenomenon for many antibiotic/bacterium combinations. However the mechanisms underlying ciprofloxacin heteroresistance in P.
Xiaodan Ma +10 more
doaj +2 more sources