Results 111 to 120 of about 5,051 (197)

Staphylococcus aureus SOS response: Activation, impact, and drug targets

mLife, Volume 3, Issue 3, Page 343-366, September 2024.
Abstract Staphylococcus aureus is a common cause of diverse infections, ranging from superficial to invasive, affecting both humans and animals. The widespread use of antibiotics in clinical treatments has led to the emergence of antibiotic‐resistant strains and small colony variants.
Kaiying Cheng, Yukang Sun, Huan Yu, Yingxuan Hu, Yini He, Yuanyuan Shen   +5 more
wiley   +1 more source

Eravacycline susceptibility was impacted by genetic mutation of 30S ribosome subunits, and branched-chain amino acid transport system II carrier protein, Na/Pi cotransporter family protein in Staphylococcus aureus

BMC Microbiology, 2020
Background Our previous research indicated the excellent in vitro antibacterial activity of Eravacycline (Erava) and its heteroresistance frequency against clinical Staphylococcus aureus isolates.
Zhanwen Wang, Zhiwei Lin, Bing Bai, Guangjian Xu, Peiyu Li, Zhijian Yu, Qiwen Deng, Yongpeng Shang, Jinxin Zheng   +8 more
doaj   +1 more source

Vancomycin AUC/MIC ratio and 30-day mortality in patients with Staphylococcus aureus bacteremia [PDF]

, 2013
A ratio of the vancomycin area under the concentration-time curve to the MIC (AUC/MIC) of ≥ 400 has been associated with clinical success when treating Staphylococcus aureus pneumonia, and this target was recommended by recently published vancomycin ...
Antibiotic Expert Group, Benjamin P. Howden, Brown, Charles, Charlson, Clinical and Laboratory Standards Institute, Cockcroft, Craig, Craig, del Mar Fernandez de Gatta Garcia, Deresinski, Drusano, Gould, Hidayat, Holland, Holmes, Holmes, Howden, Hsu, J. Owen Robinson, Jeffres, John D. Turnidge, Knaus, Kullar, Le Gall, Lodise, Lodise, Mathew, Mathew, Matthew V. N. O'Sullivan, McGregor, Mohr, Moise, Moise, Moise-Broder, Musta, Natasha E. Holmes, Neuner, Paterson, Paul D. R. Johnson, Prakash, Price, Rehm, Rose, Rule, Rybak, Rybak, Sader, Sakoulas, Sally A. Roberts, Sanchia J. C. Warren, Soriano, Tara L. Anderson, Tony M. Korman, van Hal, van Hal, Wei Gao, Wendy J. Munckhof   +57 more
core   +1 more source

Genomic analysis of Helicobacter pylori in Australia: Antimicrobial resistance, phylogenetic patterns, and virulence factors

Journal of Gastroenterology and Hepatology, Volume 39, Issue 9, Page 1869-1875, September 2024.
Abstract Background and Aim Rates of antimicrobial‐resistant Helicobacter pylori infection are rising globally, but little is known about contemporary resistance patterns, virulence factors, and phylogenetic patterns of isolates within Australia. We aimed to characterize antimicrobial resistance and genetic mutations associated with adverse clinical ...
Jonathon P Schubert, Alfred Tay, Khui Hung (Claire) Lee, Lex E X Leong, Christopher K Rayner, Morgyn S Warner, Ian C Roberts‐Thomson, Samuel P Costello, Robert V Bryant   +8 more
wiley   +1 more source

Scope and Predictive Genetic/Phenotypic Signatures of Bicarbonate (NaHCO3) Responsiveness and β-Lactam Sensitization in Methicillin-Resistant Staphylococcus aureus. [PDF]

, 2020
Addition of sodium bicarbonate (NaHCO3) to standard antimicrobial susceptibility testing medium reveals certain methicillin-resistant Staphylococcus aureus (MRSA) strains to be highly susceptible to β-lactams.
Bayer, Arnold S, Chambers, Henry F, Chen, Liang, Ersoy, Selvi C, Fowler, Vance G, Kreiswirth, Barry, Li, Liang, Mediavilla, Jose, Milan, Vanessa T, Otmishi, Mariam, Pak, Youngju, Proctor, Richard A, Xiong, Yan Q   +12 more
core   +1 more source

Impact of Resistance to Fluconazole on Virulence and Morphological Aspects of Cryptococcus neoformans and Cryptococcus gattii Isolates [PDF]

, 2016
Cryptococcus spp. are responsible for around one million cases of meningitis every year. Fluconazole (FLU) is commonly used in the treatment of cryptococcosis, mainly in immunocompromised patients and the resistance is usually reported after long periods
Ana Cecilia Mesa-Arango, Ana M. Fusco-Almeida, Haroldo C. de Oliveira, Karin Werther, Liliana Scorzoni, Maria J. S. Mendes-Giannini, Nuria Trevijano-Contador, Oscar Zaragoza, Suélen A. Rossi, Tânia de Freitas Raso   +9 more
core   +5 more sources

Carriage of an ACME II variant may have contributed to methicillin-resistant staphylococcus aureus sequence type 239-like strain replacement in Liverpool hospital, Sydney, Australia [PDF]

, 2012
Approximately 39% of methicillin-resistant Staphylococcus aureus (MRSA) sequence type 239 (ST239)-like bloodstream isolates from Liverpool Hospital (obtained between 1997 and 2008) carry an arginine catabolic mobile element (ACME).
Barbagiannakos, T., Cooper, M. A., Espedido, B. A., Gosbell, I. B., Grimmond, S. M., Jensen, S. O., Mercer, J., Paterson, D. L., Steen, J. A., van Hal, S. J.   +9 more
core   +1 more source

Approaches for identifying and measuring heteroresistance in azole-susceptible Candida isolates

Microbiology Spectrum
Heteroresistance to antifungal agents poses a significant challenge in the treatment of fungal infections. Currently, the absence of established methods for detecting and measuring heteroresistance impedes progress in understanding this phenomenon in ...
Cécile Gautier, Eli I. Maciel, Iuliana V. Ene   +2 more
doaj   +1 more source

AIDS-Related Mycoses: Current Progress in the Field and Future Priorities. [PDF]

, 2017
Opportunistic fungal infections continue to take an unacceptably heavy toll on the most disadvantaged living with HIV-AIDS, and are a major driver for HIV-related deaths. At the second EMBO Workshop on AIDS-Related Mycoses, clinicians and scientists from
Armstrong-James, D, Bicanic, T, Brown, GD, Hoving, JC, Meintjes, G, Nielsen, K, Working Group from the EMBO Workshop on AIDS-Related Mycoses   +6 more
core   +2 more sources

Aminoglycoside Heteroresistance in Acinetobacter baumannii AB5075

mSphere, 2018
Acinetobacter baumannii has become an important pathogen in hospitals worldwide, where the incidence of these infections has been increasing. A. baumannii infections have become exceedingly difficult to treat due to a rapid increase in the frequency of multidrug- and pan-resistant isolates.
Sarah E. Anderson, Edgar X. Sherman, David S. Weiss, Philip N. Rather   +3 more
openaire   +3 more sources