Epidemiology, mechanisms, and clinical impact of bacterial heteroresistance
Bacterial heteroresistance, a phenomenon where subpopulations within a bacterial strain exhibit significantly reduced antibiotic susceptibility compared to the main population, poses a major challenge in managing infectious diseases.
Linna Xu +5 more
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Impact of time to appropriate therapy on mortality in patients with vancomycin-intermediate Staphylococcus aureus infection [PDF]
Despite the increasing incidence of vancomycin-intermediate Staphylococcus aureus (VISA) infections, few studies have examined the impact of delay in receipt of appropriate antimicrobial therapy on outcomes in VISA patients.
Burnham, Carey-Ann D +3 more
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Helicobacter pylori and Its Antibiotic Heteroresistance: A Neglected Issue in Published Guidelines
“Heteroresistance” is a widely applied term that characterizes most of the multidrug-resistant microorganisms. In microbiological practice, the word “heteroresistance” indicates diverse responses to specific antibiotics by bacterial subpopulations in the
Albert A. Rizvanov +6 more
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Revisiting susceptibility testing in MDR-TB by a standardized quantitative phenotypic assessment in a European multicentre study [PDF]
Objectives Treatment outcome of MDR-TB is critically dependent on the proper use of second-line drugs as per the result of in vitro drug susceptibility testing (DST).
Böttger, E. C. +12 more
core
Should Azithromycin 1g be abandoned as a treatment for bacterial sexually transmitted infections?:The case for and against [PDF]
[no ...
Horner, Paddy J, Saunders, John
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We describe an in vivo evolution of an antimicrobial profile from susceptibility to full-resistance to carbapenems, with heteroresistance as an intermediate stage, in an Acinetobacter baumannii strain.
Silvana Vargas Superti +5 more
doaj +1 more source
The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis. [PDF]
Global tuberculosis incidence has declined marginally over the past decade, and tuberculosis remains out of control in several parts of the world including Africa and Asia.
Atre, Sachin R +41 more
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Heteroresistance to carbapenems in Acinetobacter baumannii [PDF]
S, Pournaras +4 more
openaire +2 more sources
Antibiotic heteroresistance, characterized by rare resistant subpopulations of bacteria within a susceptible main population, is associated with treatment failure and often caused by tandem amplification of resistance genes. Here, we investigated how the
Sofia Jonsson +4 more
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Vancomycin Heteroresistance in Methicillin-resistantStaphylococcus aureus, Taiwan
To the Editor: In 1997, Hiramatsu and colleagues reported the first clinical isolate of methicillin-resistant Staphylococcus aureus (MRSA) showing reduced susceptibility to vancomycin (1). Soon thereafter, vancomycin-intermediate S. aureus (VISA) or heteroresistant VISA was reported to have disseminated in Japanese hospitals (2). In Taiwan, a survey of
Wang, Jiun-Ling +3 more
openaire +2 more sources

