Results 131 to 140 of about 5,051 (197)

Progress in the Study of Polymyxin Heteroresistance Molecular Mechanisms

Xiehe Yixue Zazhi
Polymyxins, a class of cyclic peptide antibiotics, have become the last line of defense against gram-negative bacterial infections as the number of multidrug-resistant bacteria continues to rise.
LI Yanbing, ZHOU Menglan, XU Yingchun
doaj   +1 more source

Ceftazidime/avibactam Improves the Antibacterial Efficacy of Polymyxin B Against Polymyxin B Heteroresistant KPC-2-Producing Klebsiella pneumoniae and Hinders Emergence of Resistant Subpopulation in vitro

Frontiers in Microbiology, 2019
Due to the increasing multidrug resistance and limited antibiotics, polymyxin B revived as the last resort for the treatment of carbapenemase-producing Klebsiella pneumoniae (CRKP).
Xingyan Ma, Yuting He, Xuegao Yu, Yimei Cai, Jianming Zeng, Jianming Zeng, Renxin Cai, Renxin Cai, Yang Lu, Yang Lu, Liang Chen, Cha Chen, Cha Chen, Bin Huang   +13 more
doaj   +1 more source

Widespread heteroresistance to antibiotics in Lactobacillus species

AbstractLactobacilli are prevalent members of the intestinal and reproductive tract microbiota of humans and other species. They are commonly used in probiotics and various food products due to their beneficial effects on human health. For example, these beneficial microbes are used to treat diarrhea caused by antibiotic therapy and are commonly given ...
Rivera-Rodriguez, Dormarie E., Busby, Chayse, Cervantes-Barragan, Luisa, Weiss, David S.   +3 more
openaire   +2 more sources

Detection of pyrazinamide heteroresistance in Mycobacterium tuberculosis

International Journal of Mycobacteriology, 2015
AbstractAimPyrazinamide (PZA) is a first-line key agent in the effective treatment of tuberculosis (TB), including PZA susceptible multidrug-resistant tuberculosis (MDR-TB). Occasionally, TB patients might have mixed infections with both drug-sensitive and -resistant strains. This is termed heteroresistance.
Mikaela Glader, Sven Hoffner, Jim Werngren   +2 more
openaire   +2 more sources

Genetic Evaluation of Heteroresistance among Carbapenem-Susceptible Clinical Isolates of Enterobacterales

Canadian Journal of Infectious Diseases and Medical Microbiology
Carbapenems currently serve as the last line of defense when treating serious infections caused by multidrug-resistant Enterobacterales species; however, heteroresistance of these species is thought to cause failure in the treatment with these broad ...
İpek Koçer, Mehmet Eri̇nmez, Yasemin Zer   +2 more
doaj   +1 more source

Heteroresistant and nonheteroresistant methicillin-resistant Staphylococcus aureus [PDF]

Journal of Clinical Microbiology, 1987
P E, Varaldo, F, Biavasco, M P, Montanari   +2 more
openaire   +2 more sources

Three concurrent mechanisms generate gene copy number variation and transient antibiotic heteroresistance

Nature Communications
Heteroresistance is a medically relevant phenotype where small antibiotic-resistant subpopulations coexist within predominantly susceptible bacterial populations. Heteroresistance reduces treatment efficacy across diverse bacterial species and antibiotic
Hervé Nicoloff, Karin Hjort, Dan I. Andersson, Helen Wang   +3 more
doaj   +1 more source

Machine learning detection of heteroresistance in Escherichia coli

eBioMedicine
Heteroresistance (HR) is a significant type of antibiotic resistance observed for several bacterial species and antibiotic classes where a susceptible main population contains small subpopulations of resistant cells. Mathematical models, animal experiments and clinical studies associate HR with treatment failure.
Andrei Guliaev, Karin Hjort, Michele Rossi, Sofia Jonsson, Hervé Nicoloff, Lionel Guy, Dan I. Andersson   +6 more
openaire   +3 more sources

Investigation of bedaquiline heteroresistance among Mycobacterium tuberculosis isolates from Pakistan

Microbiology Spectrum
Bedaquiline is a key drug recommended by the WHO for the treatment of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant (XDR) TB, and its use could potentially shorten treatment duration with improved outcomes.
Faiqa Rashid, Shaukat Iqbal, Sabira Tahseen, Yanlin Zhao   +3 more
doaj   +1 more source

Emerging infectious diseases in Hong Kong. [PDF]

, 2001
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Yuen, KY
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