Results 31 to 40 of about 5,051 (197)
Frontiers in Microbiology, 2023 Antibiotic resistance is a major Public Health challenge worldwide. Mechanisms other than resistance are described as contributors to therapeutic failure.
Celia Gil-Campillo +15 more
doaj +1 more source
Dynamic ploidy changes drive fluconazole resistance in human cryptococcal meningitis. [PDF]
, 2018 BACKGROUND: Cryptococcal meningitis (CM) causes an estimated 180,000 deaths annually, predominantly in sub-Saharan Africa, where most patients receive fluconazole (FLC) monotherapy. While relapse after FLC monotherapy with resistant strains is frequently
Berman, J +13 more
core +6 more sources
Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance. [PDF]
, 2019 Cryptococcal meningitis is a lethal disease with few therapeutic options. Induction therapy with fluconazole has been consistently demonstrated to be associated with suboptimal microbiological and clinical outcomes. Exposure to fluconazole causes dynamic
Aller +31 more
core +1 more source
Antibiotic susceptibility, heteroresistance, and updated treatment strategies in helicobacter pylori infection [PDF]
, 2017 In this review, we discuss the problem of antibiotic resistance, heteroresistance, the utility of cultures and antibiotic susceptibility tests in Helicobacter pylori (Hp) eradication, as well as the updated treatment strategies for this infection.
De Angelis, Massimiliano +3 more
core +1 more source
Bacterial Cooperation Leads to Heteroresistance
DEStech Transactions on Computer Science and Engineering, 2018 By challenging E. coli with sublethal norfloxacin for 10 days, Henry Lee and James Collins suggests the bacterial altruism leads to the population-wide resistance. By detailedly analyzing experiment data, we suggest that bacterial cooperation leads to population-wide resistance under norfloxacin pressure and simultaneously propose the bacteria shield ...
Xu, Shilian, Yang, Jiaru, Yin, Chong
openaire +3 more sources
Antimicrobial Heteroresistance: an Emerging Field in Need of Clarity [PDF]
, 2015 “Heteroresistance” describes a phenomenon where subpopulations of seemingly isogenic bacteria exhibit a range of susceptibilities to a particular antibiotic. Unfortunately, a lack of standard methods to determine heteroresistance has led to inappropriate
El-Halfawy, Omar M., Valvano, Miguel A.
core +1 more source
Microbiology Spectrum, 2023 Colistin has been considered a last-line option for the treatment of infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). Heterogeneous resistance to colistin leads to unexplained clinical colistin treatment failure for CRKP. Our study
Yuesong Weng +9 more
doaj +1 more source
mBio, 2016 Candida glabrata causes persistent infections in patients treated with fluconazole and often acquires resistance following exposure to the drug. Here we found that clinical strains of C.
Ronen Ben-Ami +7 more
doaj +1 more source
Colistin heteroresistance in carbapenemase-producing Klebsiella pneumoniae [PDF]
Journal of Antimicrobial Chemotherapy, 2011 Sir, Klebsiella pneumoniae is an important pathogen that causes severe and life-threatening infections. Most isolates demonstrate resistance to various antimicrobial agents. Carbapenems have been widely used to treat serious infections with multidrug-resistant K. pneumoniae.
Georgios, Meletis +4 more
openaire +2 more sources
Quorum sensing regulates heteroresistance in Pseudomonas aeruginosa
Frontiers in Microbiology, 2022 The prevalence and genetic mechanism of antibiotic heteroresistance (HR) have attracted significant research attention recently. However, non-genetic mechanism of HR has not been adequately explored. The present study aimed to evaluate the role of quorum sensing (QS), an important mechanism of behavioral coordination in different subpopulations and ...
Yang Lu +12 more
openaire +3 more sources