Results 71 to 80 of about 5,051 (197)

Surface Plasmon Resonance‐based Biosensing Towards the Detection of Multidrug‐Resistant Tuberculosis

Advanced Photonics Research, Volume 7, Issue 3, March 2026.
This study presents the detection of multidrug‐resistant tuberculosis (MDR‐TB) gene targets (InhA, KatG, and RpoB) and their mutations using a surface plasmon resonance (SPR)‐based biosensing platform to monitor target binding on functionalized sensor chips.
Sipho H. Chauke, Lerato Hlekelele, Charles Maphanga, Mabotse Tjale, Felix S. Dube, Saturnin Ombinda‐Lemboumba, Patience Mthunzi‐Kufa   +6 more
wiley   +1 more source

Overexpression of KPC contributes to ceftazidime-avibactam heteroresistance in clinical isolates of carbapenem-resistant Klebsiella pneumoniae

Frontiers in Cellular and Infection Microbiology
Ceftazidime–avibactam (CZA) is one of the effective antibiotics used for the treatment of carbapenem-resistant Klebsiella pneumoniae (CRKP) infections, but its resistance rate has increased recently. Previous studies have focused on the mechanisms of CZA
Yitan Li, Xiandi Chen, Yingyi Guo, Yingzhuo Lin, Xiaohu Wang, Guohua He, Mingzhen Wang, Jianbo Xu, Mingdong Song, Xixi Tan, Chao Zhuo, Zhiwei Lin   +11 more
doaj   +1 more source

Oxidative Treatment for Reducing Persistent Populations of Escherichia coli Under Amoxicillin and Gentamicin Pressure

Journal of Biophotonics, Volume 19, Issue 3, March 2026.
Photodynamic inactivation (PDI) with methylene blue and 660 nm LED enhances antibiotic killing of bacteria, accelerating time‐kill kinetics and reducing the MDK99 compared to antibiotics alone. SEM confirms effective cellular damage, demonstrating that PDI potentiates amoxicillin and gentamicin against tolerant bacterial populations. ABSTRACT Bacterial
Bruna C. Correa, Maria Vitória S. Pereira, Vanderlei S. Bagnato, Kate C. Blanco   +3 more
wiley   +1 more source

Time-programmable drug dosing allows the manipulation, suppression and reversal of antibiotic drug resistance in vitro [PDF]

, 2017
Multi-drug strategies have been attempted to prolong the efficacy of existing antibiotics, but with limited success. Here we show that the evolution of multi-drug-resistant Escherichia coli can be manipulated in vitro by administering pairs of ...
Cronin, Leroy, Furusawa, Chikara, Galiñanes Reyes, Sabrina Galiñanes, Horinouchi, Takaaki, Tsuda, Soichiro, Yoshida, Mari   +5 more
core   +1 more source

Emerging Frontiers in Clinical Mycology: Innovations, Insights, and Impacts

Mycoses, Volume 69, Issue 1, January 2026.
ABSTRACT The Mycoses Study Group Education and Research Consortium (MSGERC)—a group comprising clinicians, researchers, patients, and industry partners—meets every 2 years to review the most significant challenges facing the clinical mycology community and plan research, education, and advocacy strategies to prevent fungal infections and improve ...
A. Apostolopoulou, A. G. Stewart, H. Yoon, J. M. Steinbrink, D. Z. P. Friedman, L. Ostrosky‐Zeichner, I. S. Schwartz, on behalf of the Mycoses Study Group Education and Research Consortium (MSGERC)   +7 more
wiley   +1 more source

Antibiotic Heteroresistance in Klebsiella pneumoniae

International Journal of Molecular Sciences, 2022
Klebsiella pneumoniae is one of the most common pathogens responsible for infections, including pneumonia, urinary tract infections, and bacteremias. The increasing prevalence of multidrug-resistant K. pneumoniae was recognized in 2017 by the World Health Organization as a critical public health threat.
openaire   +1 more source

Factors Associated with Tuberculosis and Rifampicin-Resistant Tuberculosis amongst Symptomatic Patients in India: A Retrospective Analysis [PDF]

, 2016
Background Tuberculosis remains a major public health challenge for India. Various studies have documented different levels of TB and multi-drug resistant (MDR) TB among diverse groups of the population.
Arinaminpathy, N, Boehme, C, Denkinger, C, Dewan, P, Kulsange, S, Nair, SA, Paramsivan, CN, Raizada, N, Sachdeva, KS, Schumacher, S   +9 more
core   +1 more source

Mechanisms of heteroresistance in methicillin-resistant Staphylococcus aureus [PDF]

Antimicrobial Agents and Chemotherapy, 1994
Characteristic for methicillin-resistant (Mcr) staphylococci is the heterogeneous expression of the intrinsic methicillin resistance. The majority of the cells express resistance to low concentrations of methicillin, and a minority of the cells express resistance to much higher concentrations.
C, Ryffel, A, Strässle, F H, Kayser, B, Berger-Bächi   +3 more
openaire   +2 more sources

Colistin heteroresistance in Klebsiella pneumonia and its association with slow-growing subpopulations within biofilms [PDF]

, 2016
The emergence of multidrug-resistant strains of Klebsiella pneumoniae is a growing clinical concern that is leading to the re-introduction of the old and toxic colistin as a salvage therapy.
Alves, Diana Filipa Barros, Lourenço, Anália, Pereira, Maria Olívia, Silva, Ana Maria Alves Machado Gonçalves da, Sousa, Ana Margarida   +4 more
core  

Heteroresistance and clinical outcomes: knowledge gaps

The Lancet Microbe
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Leanza, Gabriele Maria, Murri, Rita, Sanguinetti, Maurizio, Torti, Carlo   +3 more
openaire   +3 more sources