Molecular mechanisms of plant NLR activation and signalling
The Plant Journal, Volume 125, Issue 3, February 2026.SUMMARY Plants rely on NLRs (nucleotide‐binding leucine‐rich repeat receptors) to recognise effector proteins secreted by pathogens into plant cells and to deliver disease resistance. Plant NLRs are broadly characterised by their N‐terminal domains, which include the TIR (Toll/interleukin‐1 receptor) and the CC (coiled‐coil) domains.
Natsumi Maruta +3 more
wiley +1 more source
Cdc24 Regulates Nuclear Shuttling and Recruitment of the Ste5 Scaffold to a Heterotrimeric G Protein in Saccharomyces cerevisiae [PDF]
, 2005 Yunmei Wang +3 more
openalex +1 more source
Heterotrimeric G-protein signaling in Arabidopsis [PDF]
Plant Signaling & Behavior, 2008 Seven transmembrane G-protein-coupled receptors (GPCRs) are commonly used by eukaryotes to sense extracellular signals to switch on cellular responses through the activation of cognate heterotrimeric G-proteins. In Arabidopsis thaliana, GCR2 has been proposed as a GPCR for the plant hormone abscisic acid.
openaire +2 more sources
From isolation to insights: mitochondrial complex I in the diatom Phaeodactylum tricornutum
The Plant Journal, Volume 125, Issue 3, February 2026.SUMMARY Diatoms are among the most ecologically successful microalgae, contributing significantly to marine primary production and global carbon cycling. Their distinctive metabolic architecture, shaped by a complex evolutionary history involving secondary endosymbiosis, includes a highly compartmentalized cell organization and unique metabolic ...
Federico Berdun +7 more
wiley +1 more source
Characterization of the heterotrimeric G protein gene families in Triticum aestivum and related species. [PDF]
3 Biotech, 2022 Gawande ND +3 more
europepmc +1 more source
The Interaction of Phospholipase C-{beta}3 with Shank2 Regulates mGluR-mediated Calcium Signal [PDF]
, 2005 Phospholipase C-{beta} isozymes that are activated by G protein-coupled receptors (GPCR) and heterotrimeric G proteins carry a PSD-95/Dlg/ZO-1 (PDZ) domain binding motif at their C terminus. Through interactions with PDZ domains, this motif may endow the
Hwang, Jong-Ik +5 more
core
Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies
The FASEB Journal, Volume 40, Issue 1, 15 January 2026.Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati +4 more
wiley +1 more source
Significant reduction of Bi
, 2014 Timothy E. Gookin, Sarah M. Assmann
openalex +1 more source
No evidence for oncogenic mutations in guanine nucleotide-binding proteins of human adrenocortical neoplasms [PDF]
, 1933 G-Proteins are membrane-bound heterotrimeric polypeptides that couple receptor signals to second messenger systems such as cAMP. Recently, point mutations at 2 codons of the highly preserved alpha-chain of Gs, the adenyl cyclase-stimulating G-protein ...
Chrousos, G. P. +3 more
core
A Sphingolipid Elicitor-Inducible Mitogen-Activated Protein Kinase Is Regulated by the Small GTPase OsRac1 and Heterotrimeric G-Protein in Rice [PDF]
, 2005 Damien Lieberherr +5 more
openalex +1 more source