Results 171 to 180 of about 22,486 (204)
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Biochemical and Biophysical Research Communications, 1992
Heterotrimeric guanine nucleotide binding proteins transduce signals from cell surface receptors to intracellular effectors. The alpha subunit is believed to confer receptor and effector specificity on the G protein. This role is reflected in the diversity of genes that encode these subunits.
E, von Weizsäcker +2 more
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Heterotrimeric guanine nucleotide binding proteins transduce signals from cell surface receptors to intracellular effectors. The alpha subunit is believed to confer receptor and effector specificity on the G protein. This role is reflected in the diversity of genes that encode these subunits.
E, von Weizsäcker +2 more
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Association of heterotrimeric GTP binding regulatory protein (Go) with mitosis.
Laboratory investigation; a journal of technical methods and pathology, 1994The heterotrimeric GTP-binding regulatory proteins (or G proteins) play an important role in regulation of membrane signal transduction. Previously, we have identified the beta-subunit of G proteins (G beta) to be closely associated with mitotic spindles. In the present study, we have conducted experiments to examine whether the G alpha subunit is also
H C, Wu, C T, Lin
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European Journal of Pharmacology, 1999
The effects of volatile anesthetics on guanine nucleotide binding to the purified alpha subunits of heterotrimeric GTP binding (G) proteins were studied. At sub-anesthetic doses, halothane, isoflurane, enflurane and sevoflurane inhibit exchange of GTPgammaS for GDP bound to Galpha subunits and markedly enhance the dissociation of GTPgammaS, but fail to
S N, Pentyala +3 more
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The effects of volatile anesthetics on guanine nucleotide binding to the purified alpha subunits of heterotrimeric GTP binding (G) proteins were studied. At sub-anesthetic doses, halothane, isoflurane, enflurane and sevoflurane inhibit exchange of GTPgammaS for GDP bound to Galpha subunits and markedly enhance the dissociation of GTPgammaS, but fail to
S N, Pentyala +3 more
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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1993
Direct photoaffinity labeling of proteins of longitudinal sarcoplasmic reticulum (LSR) of rabbit skeletal muscle with [32P]GTP revealed GTP-binding proteins of about 52, 45 and 30 kDa. ADP-ribosylation with [32P]NAD in the presence of cholera toxin (CTX) or pertussis toxin (PTX) indicates the existence of a CTX substrate (about 45 kDa); no PTX ...
H, Kutchai, L M, Geddis, A S, Otero
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Direct photoaffinity labeling of proteins of longitudinal sarcoplasmic reticulum (LSR) of rabbit skeletal muscle with [32P]GTP revealed GTP-binding proteins of about 52, 45 and 30 kDa. ADP-ribosylation with [32P]NAD in the presence of cholera toxin (CTX) or pertussis toxin (PTX) indicates the existence of a CTX substrate (about 45 kDa); no PTX ...
H, Kutchai, L M, Geddis, A S, Otero
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1992
G-proteins convey extracellular signals from cell surface receptors to diverse effectors such as enzymes of second messenger metabolism and ion channels. Receptor-effector coupling G-proteins are composed of three subunits, α, β, and γ, each separate gene products. Multiple forms of each type of subunit have been identified at the DNA and protein level
Allen M. Spiegel +5 more
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G-proteins convey extracellular signals from cell surface receptors to diverse effectors such as enzymes of second messenger metabolism and ion channels. Receptor-effector coupling G-proteins are composed of three subunits, α, β, and γ, each separate gene products. Multiple forms of each type of subunit have been identified at the DNA and protein level
Allen M. Spiegel +5 more
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[Role of heterotrimeric GTP-binding proteins in cellular signaling].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1994The GTP-binding protein (G protein) is a heterotrimeric protein composed of an alpha-, a beta- and a gamma-subunit. The G protein is functionally located between membrane receptors whose structures are characterized by seven membrane-spanning domains and effectors that are enzymes responsible for the generation of intracellular second messengers or ...
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Activation of Heterotrimeric GTP-Binding Proteins Upon TCR/CD3 Engagement
2003C D, Tsoukas, J, Stanners, K A, Ching
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Heterotrimeric GTP‐binding proteins: An expanding family of signal transducers
Medicinal Research Reviews, 1992openaire +2 more sources