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Immunological Probes of the Structure, Function, and Expression of Heterotrimeric GTP-Binding Proteins

1992
G-proteins convey extracellular signals from cell surface receptors to diverse effectors such as enzymes of second messenger metabolism and ion channels. Receptor-effector coupling G-proteins are composed of three subunits, α, β, and γ, each separate gene products. Multiple forms of each type of subunit have been identified at the DNA and protein level
Allen M. Spiegel   +5 more
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Association of heterotrimeric GTP binding regulatory protein (Go) with mitosis.

Laboratory investigation; a journal of technical methods and pathology, 1994
The heterotrimeric GTP-binding regulatory proteins (or G proteins) play an important role in regulation of membrane signal transduction. Previously, we have identified the beta-subunit of G proteins (G beta) to be closely associated with mitotic spindles. In the present study, we have conducted experiments to examine whether the G alpha subunit is also
H C, Wu, C T, Lin
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[Role of heterotrimeric GTP-binding proteins in cellular signaling].

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1994
The GTP-binding protein (G protein) is a heterotrimeric protein composed of an alpha-, a beta- and a gamma-subunit. The G protein is functionally located between membrane receptors whose structures are characterized by seven membrane-spanning domains and effectors that are enzymes responsible for the generation of intracellular second messengers or ...
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