Phosphorylation-activated G protein signaling stabilizes TCP14 and JAZ3 to repress JA signaling and enhance plant immunity. [PDF]
Jia H +12 more
europepmc +1 more source
Prevalence, distribution, and mechanisms of genetic dominance in the yeast mating pathway. [PDF]
Allen MG, Martínez AA, Lang GI.
europepmc +1 more source
Atypical GNAO1 variants in severe childhood speech disorders: clinical, genetic, and molecular insights. [PDF]
Larasati YA +8 more
europepmc +1 more source
Recent breakthroughs in understanding the allosteric features of Ras GTPases and their effector and regulatory protein interactions, enabling drug design. [PDF]
Bhattarai N, Buck M.
europepmc +1 more source
HIV-1 capsid interactions with Nuclear Pore Complex components support nuclear entry via affinity gradient. [PDF]
Melčák I +8 more
europepmc +1 more source
Measurement of GTP-Binding and GTPase Activity of Heterotrimeric Gα Proteins
Heterotrimeric G-proteins are important signaling intermediates in all eukaryotes. These proteins link signal perception by a cell surface localized receptor to the downstream effectors of a given signaling pathways. The minimal core of the heterotrimeric G-protein complex consists of Gα, Gβ, and Gγ subunits, the G protein coupled receptor (GPCR) and ...
Swarup Roy, Choudhury +3 more
openaire +3 more sources
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Evidence of a Role for Heterotrimeric GTP-Binding Proteins in Endosome Fusion
Science, 1992Guanosine triphosphate (GTP)-binding proteins are required for intracellular vesicular transport. Mastoparan is a peptide component of wasp venom that increases nucleotide exchange in some classes of Gα subunits of regulatory heterotrimeric GTP-binding proteins (G proteins).
María Isabel Colombo +2 more
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Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go
Biochemistry, 1988Using high-resolution Mono-Q anion-exchange chromatography, we purified four distinct GTP-binding proteins from bovine brain. Each consists of alpha and associated beta/gamma subunits, and each is a substrate for pertussis toxin catalyzed ADP-ribosylation.
Graeme Milligan +2 more
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