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Evidence of a role for heterotrimeric GTP-binding proteins in endosome fusion
Science, 1992Guanosine triphosphate (GTP)-binding proteins are required for intracellular vesicular transport. Mastoparan is a peptide component of wasp venom that increases nucleotide exchange in some classes of Gα subunits of regulatory heterotrimeric GTP-binding proteins (G proteins).
Maria I Colombo +2 more
exaly +4 more sources
Activation of Heterotrimeric GTP-Binding Proteins
, 1999 Guanosine triphosphate- (GTP-) binding proteins constitute a supergene family of proteins that utilize GTP binding and hydrolysis as a chemical switch. These proteins are activated by exchanging bound guanosine diphosphate (GDP) with GTP and are subsequently inactivated by hydrolyzing bound GTP to GDP.1–3 Hence, by shuttling between an inactive, GDP ...
Ronit Sagi-Eisenberg
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, 1992 G-proteins convey extracellular signals from cell surface receptors to diverse effectors such as enzymes of second messenger metabolism and ion channels. Receptor-effector coupling G-proteins are composed of three subunits, α, β, and γ, each separate gene products. Multiple forms of each type of subunit have been identified at the DNA and protein level
Allen M. Spiegel +5 more
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Purification of heterotrimeric GTP-binding proteins from brain: identification of a novel form of Go
Biochemistry, 1988Using high-resolution Mono-Q anion-exchange chromatography, we purified four distinct GTP-binding proteins from bovine brain. Each consists of alpha and associated beta/gamma subunits, and each is a substrate for pertussis toxin catalyzed ADP-ribosylation.
Paul Goldsmith +2 more
exaly +3 more sources
European Journal of Pharmacology, 1999
The effects of volatile anesthetics on guanine nucleotide binding to the purified alpha subunits of heterotrimeric GTP binding (G) proteins were studied. At sub-anesthetic doses, halothane, isoflurane, enflurane and sevoflurane inhibit exchange of GTPgammaS for GDP bound to Galpha subunits and markedly enhance the dissociation of GTPgammaS, but fail to
Mario J Rebecchi
exaly +3 more sources
The effects of volatile anesthetics on guanine nucleotide binding to the purified alpha subunits of heterotrimeric GTP binding (G) proteins were studied. At sub-anesthetic doses, halothane, isoflurane, enflurane and sevoflurane inhibit exchange of GTPgammaS for GDP bound to Galpha subunits and markedly enhance the dissociation of GTPgammaS, but fail to
Mario J Rebecchi
exaly +3 more sources