Results 101 to 110 of about 6,621 (215)

On the facultative requirement of the bacterial RNA chaperone, Hfq [PDF]

Trends in Microbiology, 2009
The pleiotropic post-transcriptional regulator Hfq is an RNA chaperone that facilitates pairing interactions between small regulatory RNAs (sRNAs) and their mRNA targets in several bacteria. However, this classical pattern, derived from the Escherichia coli model, is not applicable to the whole bacterial kingdom.
Jousselin, Ambre, Metzinger, Laurent, Felden, Brice   +2 more
openaire   +3 more sources

The RNA chaperone Hfq is a novel regulator of catalase expression and hydrogen peroxide-induced oxidative stress response in Listeria monocytogenes EGD-e.

Free Radical Biology & Medicine
The RNA chaperone Hfq plays a pivotal role in many bacteria, acting as a regulator of gene expression and promoting interaction between mRNA-sRNA pairs in Gram-negative bacteria.
André F. Seixas, A. F. Q. Silva, J. Sousa, C. Arraiano, J. M. Andrade   +4 more
semanticscholar   +1 more source

An RNA-centric global view of Clostridioides difficile reveals broad activity of Hfq in a clinically important gram-positive bacterium

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Clostridioides difficile is the leading cause of healthcare-associated diarrhea worldwide following antibiotic treatment. Consequently, there is medical need for novel antibacterial agents acting against C.
Manuela Fuchs, Vanessa Lamm-Schmidt, Johannes Sulzer, Falk Ponath, L. Jenniches, J. Kirk, Robert P. Fagan, Lars Barquist, J. Vogel, F. Faber   +9 more
semanticscholar   +1 more source

Multifaceted Interplay between Hfq and the Small RNA GssA in Pseudomonas aeruginosa

mBio, 2022
The pathogenic lifestyle of the bacterium Pseudomonas aeruginosa, a leading cause of life-threatening infections in the airways of cystic fibrosis patients, is based on the fine regulation of virulence-associated factors.
Silvia Santoro, C. Paganin, Sara Gilardi, T. Brignoli, G. Bertoni, S. Ferrara   +5 more
semanticscholar   +1 more source

The MarR Family Transcriptional Regulator EmrR Negatively Regulates the Type III Secretion System (T3SS) and Positively Modulates Pathogenicity in Dickeya oryzae

Molecular Plant Pathology, Volume 27, Issue 4, April 2026.
This study revealed that the transcriptional regulator EmrR in Dickeya oryzae modulates virulence by regulating hrpL expression and c‐di‐GMP levels. It affects motility, biofilm formation, cellulase production and pathogenicity. EMSA and footprinting confirmed EmrR binds directly to the promoter of its target operon.
Mingfa Lv, Wenqi Huang, Ziwei Meng, Xiaojing Fan, Peng Li, Zeling Xu, Shaohua Chen, Xiaoyuan Chen, Jianuan Zhou, Lianhui Zhang, Yingying Cheng, Tao Zhuo, Ming Hu   +12 more
wiley   +1 more source

Hfq regulates the expression of the thermostable direct hemolysin gene in Vibrio parahaemolyticus

BMC Microbiology, 2008
Background The hfq gene is conserved in a wide variety of bacteria and Hfq is involved in many cellular functions such as stress responses and the regulation of gene expression.
Mawatari Kazuaki, Harada Nagakatsu, Su Zehong, Takahashi Akira, Nakano Masayuki, Nakaya Yutaka   +5 more
doaj   +1 more source

Hfq-Antisense RNA I Binding Regulates RNase E-Dependent RNA Stability and ColE1 Plasmid Copy Number

International Journal of Molecular Sciences
The mechanisms and consequences of gene regulation by Hfq on trans-encoded small RNAs (sRNAs) have been well studied and documented. Recent employment of Genomic SELEX to search for Hfq-binding motifs has indicated that Hfq might frequently regulate gene
Weisheng Wang, Sue Lin-Chao
semanticscholar   +1 more source

Positive regulation by small RNAs and the role of Hfq [PDF]

Proceedings of the National Academy of Sciences, 2010
Bacterial small noncoding RNAs carry out both positive and negative regulation of gene expression by pairing with mRNAs; in Escherichia coli , this regulation often requires the RNA chaperone Hfq.
Toby, Soper, Pierre, Mandin, Nadim, Majdalani, Susan, Gottesman, Sarah A, Woodson   +4 more
openaire   +2 more sources

Hfq affects mRNA levels independently of degradation [PDF]

BMC Molecular Biology, 2010
Abstract Background The bacterial Lsm protein, Hfq, is an RNA chaperone involved in many reactions related to RNA metabolism, such as replication and stability, control of small RNA activity and polyadenylation. Despite this wide spectrum of known functions, the global role of Hfq is almost certainly undervalued; its ...
Le Derout, Jacques, Boni, Irina V, Régnier, Philippe, Hajnsdorf, Eliane   +3 more
openaire   +3 more sources

SUPER: Upcycling Genetic Parts for Precise Gene Expression Control, Leakage Minimization, and Genetic Circuit Stability

Advanced Science, Volume 13, Issue 12, 27 February 2026.
To precisely modulate natural and synthetic regulatory parts, SUPER is introduced as a sophisticated and tunable controller of genetic devices without requiring sequence modification on the target. SUPER enhances dynamic range of RNA‐, chemical‐, temperature‐, and protein‐responsive biosensors up to 1011%, and converts biosensors to cover an expanded ...
Taeyang Heo, Dongwon Park, Woosub Shin, Jongmin Kim   +3 more
wiley   +1 more source