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Correlations of PTEN and ERG Immunoexpression in Prostate Carcinoma and Lesions Related to Its Natural History: Clinical Perspectives [PDF]
Current Issues in Molecular Biology, 2023 Purpose: The aim of our study was to observe the associations between the ETS-related gene (ERG) and the phosphatase and tensin homolog gene (PTEN) immunoexpression in prostate cancer and related lesions and highlight the clinical significance of these ...
Olga Voulgari +6 more
doaj +2 more sources
Alteration of proliferation and apoptotic markers in normal and premalignant tissue associated with prostate cancer [PDF]
BMC Cancer, 2006 Background Molecular markers identifying alterations in proliferation and apoptotic pathways could be particularly important in characterizing high-risk normal or pre-neoplastic tissue. We evaluated the following markers: Ki67, Minichromosome Maintenance
Yang Ximing J +4 more
doaj +4 more sources
Expression of ERG protein, a prostate cancer specific marker, in high grade prostatic intraepithelial neoplasia (HGPIN): lack of utility to stratify cancer risks associated with HGPIN [PDF]
BJU International, 2012 Study Type – Diagnosis (cohort) Level of Evidence 2b What's known on the subject? and What does the study add? High grade prostatic intraepithelial neoplasia is a pre‐malignant lesion to prostate cancer and ...
Cristina Magi-Galluzzi +2 more
exaly +3 more sources
Neoplasia, 2006 TMPRSS2-ETS gene fusions have been found recurrently in prostate carcinomas, but not in the presumed precursor lesion, high-grade prostatic intraepithelial neoplasia (HGPIN). However, HGPIN lesions may share chromosomal changes with prostate cancer.
Nuno Cerveira, Ana Peixoto, Rui Henrique
exaly +3 more sources
BMC Urology, 2009 Background High-grade prostatic intraepithelial neoplasia (HGPIN) is a precursor lesion to prostate cancer (CaP). UK-based studies examining the occurrence of isolated HGPIN and subsequent risk of CaP are lacking.
Francis L Martin
exaly +3 more sources
Journal of the Egyptian National Cancer Institute, 2014 Background: Histopathological differentiation between BCH and HGPIN in prostatic needle biopsies is a diagnostic challenge. The gold standard for detection of HGPIN and BCH is histopathological examination; however subjectivity in interpretation and tiny
Eman M S Muhammad, Mohammed Zaki
exaly +3 more sources
The impact of zinc and testosterone co-treatment on tumourigenesis in prostate cancer: a novel model [PDF]
BMC CancerBackground Pre-clinical models play a key role in prostate cancer research, helping to understand the mechanism of the disease. The unavailability of suitable animal models in under-resourced areas, such as in sub-Saharan African (SSA) countries ...
Kofi Oduro Yeboah +8 more
doaj +2 more sources
Experimental and Therapeutic Medicine, 2020 Atypical small acinar proliferation (ASAP) and high grade intraepithelial neoplasia (HGPIN) patterns identified at prostate biopsy yield an important clinical significance, their presence signaling an increased likelihood of future oncological development or underdiagnosed PCa.
David Andras
exaly +4 more sources
Preliminary clinical practice of radical prostatectomy without preoperative biopsy [PDF]
Chinese Medical Journal. Background:. At present, biopsy is essential for the diagnosis of prostate cancer (PCa) before radical prostatectomy (RP). However, with the development of prostate-specific membrane antigen positron emission tomography/computed tomography (PSMA PET ...
Ranlu Liu +13 more
doaj +2 more sources
Evaluation of clinical outcomes of patients with HGPIN on prostate biopsy
European Urology Open Science, 2023 K. Daly +5 more
exaly +2 more sources