Results 21 to 30 of about 4,130 (205)

Effect of Magnesium on Replication of Rhinovirus HGP [PDF]

Journal of Virology, 1967
It is known that plaque formation by some rhinoviruses is greatly enhanced by increasing the concentration of MgCl 2 . The mechanism of this action was studied by investigating the effects of MgCl 2 on rhinovirus HGP adsorption, growth, clumping, thermal stability, and cell susceptibility to ...
M, Fiala, G E, Kenny
openaire   +2 more sources

Altered behavior with an organic cause: a case report

Journal of Medical Case Reports, 2019
Background Insulinomas are pancreatic endocrine tumors of rare incidence worldwide, the vast majority are of single occurrence and benign. These may not always present with the clear symptoms described in the literature and may be overlooked because ...
Dolores Mejía, Rafael Contreras, Guarina Molina, Michael Alcántara   +3 more
doaj   +1 more source

Impact of MnTBAP and Baricitinib Treatment on Hutchinson–Gilford Progeria Fibroblasts

Pharmaceuticals, 2022
Hutchinson–Gilford progeria syndrome (HGPS) is a rare premature aging disease. It is caused by a mutation in the LMNA gene, which results in a 50-amino-acid truncation of prelamin A.
Elena Vehns, Rouven Arnold, Karima Djabali   +2 more
doaj   +1 more source

Arterial stiffness and cardiac dysfunction in Hutchinson–Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase

Life Science Alliance, 2021
The findings show that increased lysyl oxidase abundance is causal for the elevated arterial stiffness present in the arteries of Hutchinson–Gilford Progeria Syndrome mice.
Ryan von Kleeck, Emilia Roberts, Paola Castagnino, Kyle Bruun, Sonja A Brankovic, Elizabeth A Hawthorne, Tina Xu, John W Tobias, Richard K Assoian   +8 more
doaj   +1 more source

Metabolic Dysfunction in Hutchinson–Gilford Progeria Syndrome

Cells, 2020
Hutchinson−Gilford Progeria Syndrome (HGPS) is a segmental premature aging disease causing patient death by early teenage years from cardiovascular dysfunction.
Ray Kreienkamp, Susana Gonzalo
doaj   +1 more source

Rescue of Mitochondrial Function in Hutchinson-Gilford Progeria Syndrome by the Pharmacological Modulation of Exportin CRM1

Cells, 2023
Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder caused by the expression of progerin, a mutant variant of Lamin A. Recently, HGPS studies have gained relevance because unraveling its underlying mechanism would help to ...
Feliciano Monterrubio-Ledezma, Fernando Navarro-García, Lourdes Massieu, Ricardo Mondragón-Flores, Luz Adriana Soto-Ponce, Jonathan J. Magaña, Bulmaro Cisneros   +6 more
doaj   +1 more source

Mesenchymal stem cells derived from patients with premature aging syndromes display hallmarks of physiological aging

Life Science Alliance, 2022
Using of genome-wide approaches on models from laminopathies with or without progerin accumulation (HGPS, HGPS-L, APS), this study provides new insights on pathways altered during early stages of mesenchymal stem cells differentiation.
Jean Philippe Trani, Raphaël Chevalier, Leslie Caron, Claire El Yazidi, Natacha Broucqsault, Léa Toury, Morgane Thomas, Karima Annab, Bernard Binetruy, Annachiara De Sandre-Giovannoli, Nicolas Levy, Frédérique Magdinier, Jérôme D Robin   +12 more
doaj   +1 more source

Molecular and Cellular Mechanisms Driving Cardiovascular Disease in Hutchinson-Gilford Progeria Syndrome: Lessons Learned from Animal Models

Cells, 2021
Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disease that recapitulates many symptoms of physiological aging and precipitates death. Patients develop severe vascular alterations, mainly massive vascular smooth muscle cell loss, vessel ...
Ignacio Benedicto, Beatriz Dorado, Vicente Andrés   +2 more
doaj   +1 more source

A Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome Using Human iPSC-derived Smooth Muscle Cells

Scientific Reports, 2017
Hutchison-Gilford Progeria Syndrome (HGPS) is a rare, accelerated aging disorder caused by nuclear accumulation of progerin, an altered form of the Lamin A gene. The primary cause of death is cardiovascular disease at about 14 years. Loss and dysfunction
Leigh Atchison, Haoyue Zhang, Kan Cao, George A. Truskey   +3 more
doaj   +1 more source

Behind the scenes of the HGP [PDF]

Nature Genetics, 2003
Future geneticists will probably reflect on the Human Genome Project (HGP) as a milestone in their field. Perhaps it will be recognized alongside the chromosome theory of inheritance, the transforming material as DNA, the double helical structure for the genetic material and the cracking of the genetic code.
openaire   +1 more source