Results 31 to 40 of about 4,214 (205)

Effect of Magnesium on Replication of Rhinovirus HGP [PDF]

Journal of Virology, 1967
It is known that plaque formation by some rhinoviruses is greatly enhanced by increasing the concentration of MgCl 2 . The mechanism of this action was studied by investigating the effects of MgCl 2 on rhinovirus HGP adsorption, growth, clumping, thermal stability, and cell susceptibility to ...
M, Fiala, G E, Kenny
openaire   +2 more sources

A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells

eLife, 2021
A farnesylated and methylated form of prelamin A called progerin causes Hutchinson-Gilford progeria syndrome (HGPS). Inhibiting progerin methylation by inactivating the isoprenylcysteine carboxylmethyltransferase (ICMT) gene stimulates proliferation of ...
Xue Chen, Haidong Yao, Muhammad Kashif, Gwladys Revêchon, Maria Eriksson, Jianjiang Hu, Ting Wang, Yiran Liu, Elin Tüksammel, Staffan Strömblad, Ian M Ahearn, Mark R Philips, Clotilde Wiel, Mohamed X Ibrahim, Martin O Bergo   +14 more
doaj   +1 more source

Altered behavior with an organic cause: a case report

Journal of Medical Case Reports, 2019
Background Insulinomas are pancreatic endocrine tumors of rare incidence worldwide, the vast majority are of single occurrence and benign. These may not always present with the clear symptoms described in the literature and may be overlooked because ...
Dolores Mejía, Rafael Contreras, Guarina Molina, Michael Alcántara   +3 more
doaj   +1 more source

Metabolic Dysfunction in Hutchinson–Gilford Progeria Syndrome

Cells, 2020
Hutchinson−Gilford Progeria Syndrome (HGPS) is a segmental premature aging disease causing patient death by early teenage years from cardiovascular dysfunction.
Ray Kreienkamp, Susana Gonzalo
doaj   +1 more source

Rescue of Mitochondrial Function in Hutchinson-Gilford Progeria Syndrome by the Pharmacological Modulation of Exportin CRM1

Cells, 2023
Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder caused by the expression of progerin, a mutant variant of Lamin A. Recently, HGPS studies have gained relevance because unraveling its underlying mechanism would help to ...
Feliciano Monterrubio-Ledezma, Fernando Navarro-García, Lourdes Massieu, Ricardo Mondragón-Flores, Luz Adriana Soto-Ponce, Jonathan J. Magaña, Bulmaro Cisneros   +6 more
doaj   +1 more source

Arterial stiffness and cardiac dysfunction in Hutchinson–Gilford Progeria Syndrome corrected by inhibition of lysyl oxidase

Life Science Alliance, 2021
The findings show that increased lysyl oxidase abundance is causal for the elevated arterial stiffness present in the arteries of Hutchinson–Gilford Progeria Syndrome mice.
Ryan von Kleeck, Emilia Roberts, Paola Castagnino, Kyle Bruun, Sonja A Brankovic, Elizabeth A Hawthorne, Tina Xu, John W Tobias, Richard K Assoian   +8 more
doaj   +1 more source

HGPS-Derived iPSCs For The Ages [PDF]

Cell Stem Cell, 2011
In this issue of Cell Stem Cell, Zhang et al. (2011) generate patient-derived iPSCs for one of the major premature aging diseases, Hutchinson-Gilford Progeria Syndrome (HGPS). These cells are a much-needed new tool to study HGPS, and their use may lead to novel insights into mechanisms of aging.
openaire   +2 more sources

A Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome Using Human iPSC-derived Smooth Muscle Cells

Scientific Reports, 2017
Hutchison-Gilford Progeria Syndrome (HGPS) is a rare, accelerated aging disorder caused by nuclear accumulation of progerin, an altered form of the Lamin A gene. The primary cause of death is cardiovascular disease at about 14 years. Loss and dysfunction
Leigh Atchison, Haoyue Zhang, Kan Cao, George A. Truskey   +3 more
doaj   +1 more source

METTL14‐Mediated m6A Methylation Preserves Cardiomyocyte Homeostasis and Attenuates Progeria‐Associated Cardiac Remodeling [PDF]

Aging Cell
Progerin accumulation downregulates the expression of m6A methyltransferases METTL3 and METTL14 in cardiac tissues, impairing m6A modification‐mediated regulation of target genes including Casq2, Ifna and Ifnb, leading to calcium signaling dysregulation and pro‐inflammatory activation in the aged heart.
Wang S, Zhang J, Ao Y, Rao D, Yu C, Xu C, Wang M, Li M, Huang X, Zhang J, Mei R, Zhang Z, Sun J, Duan J, Sun Y, Wang Z, Su W, Liu B.   +17 more
europepmc   +2 more sources

Behind the scenes of the HGP [PDF]

Nature Genetics, 2003
Future geneticists will probably reflect on the Human Genome Project (HGP) as a milestone in their field. Perhaps it will be recognized alongside the chromosome theory of inheritance, the transforming material as DNA, the double helical structure for the genetic material and the cracking of the genetic code.
openaire   +1 more source