Results 51 to 60 of about 7,722 (240)
Nucleus, 2019 Lamin A, a product of the LMNA gene, is an essential nuclear envelope component in most differentiated cells. Mutations in LMNA have been linked to premature aging disorders, including Hutchinson-Gilford progeria syndrome (HGPS).
Magda R. Hamczyk, Vicente Andrés
doaj +1 more source
HGPS (Hutchinson-Gilford -Progeria syndrome)
IP Journal of Surgery and Allied Sciences, 2020 Eight year old male child, born of non- consanguinity presented with complaints of irritability and drowsiness with history of left sided weakness. He was stunted and had hypertension at presentation. Also he had dysmorphic features and skin manifestations with skeletal deformities and muscle wasting.
Santosh Kondekar +4 more
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Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13
Nature Communications, 2020 Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease and smooth muscle cells are the most affected cells in HGPS individuals. Here, the authors report a microfluidics platform with HGPS induced pluripotent stem cells and show that ...
Patricia R. Pitrez +20 more
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IEEE Access, 2023 Multi-vector smart local energy systems are playing an increasingly importantly role in the fast-track decarbonisation of our global energy services. An emergent contributor to global decarbonisation is green hydrogen. Green hydrogen can remove or reduce
Hani Gharavi Ahangar +2 more
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Cell Reports, 2014 Summary: Advanced age and DNA damage accumulation are prominent risk factors for cancer. The premature aging disorder Hutchinson-Gilford progeria syndrome (HGPS) provides a unique opportunity for studying the interplay between DNA damage and aging ...
Patricia Fernandez +5 more
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Generation of a Hutchinson–Gilford progeria syndrome monkey model by base editing
Protein & Cell, 2020 Many human genetic diseases, including Hutchinson-Gilford progeria syndrome (HGPS), are caused by single point mutations. HGPS is a rare disorder that causes premature aging and is usually caused by a de novo point mutation in the LMNA gene. Base editors
Fang Wang +17 more
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, 2023 Human Genome Project by Genetic Manipulation lecture for Agriculture, Biology, Botany, Zoology, Chemistry, Biotechnology, Microbiology, and Genetics Students by Salman Saeed Lecturer Botany University College of Management and Sciences Khanewal, Pakistan.
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Carbon Energy, EarlyView.Fe‐CoMoO4‐Ov/NF demonstrates significantly improved OER catalytic performance compared to CoMoO4. Specifically, the introduced Fe atoms act as a promoter for surface reconstruction, significantly reducing the energy required for surface reconstruction to generate FeCoOOH. The oxygen vacancies serve as electron channels between the core Fe‐CoMoO4‐Ov and
Chaojie Lyu +4 more
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The Molecular and Cellular Basis of Hutchinson–Gilford Progeria Syndrome and Potential Treatments
Genes, 2023 Hutchinson–Gilford progeria syndrome (HGPS) is a rare, autosomal-dominant, and fatal premature aging syndrome. HGPS is most often derived from a de novo point mutation in the LMNA gene, which results in an alternative splicing defect and the generation ...
Noelle Batista +11 more
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Reductions in gammaH2AX response in HGPS cells are cell cycle dependent. [PDF]
, 2016 (A). Representative fluorescence images of gammaH2AX foci and BrdU staining in middle passage normal and HGPS fibroblasts after Dox treatment. G0/G1 and S phase were indicated by BrdU negative and positive staining respectively. Scale Bar: 5um.
Celeste Witting (3372776) +6 more
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