Results 61 to 70 of about 4,214 (205)

Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria

EMBO Molecular Medicine, 2021
Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson–Gilford progeria syndrome (HGPS). In this study, we present evidence of increased expression of the components of the NLRP3 inflammasome pathway in HGPS skin ...
Alvaro González‐Dominguez, Raúl Montañez, Beatriz Castejón‐Vega, Jéssica Nuñez‐Vasco, Débora Lendines‐Cordero, Chun Wang, Gabriel Mbalaviele, José M Navarro‐Pando, Elísabet Alcocer‐Gómez, Mario D Cordero   +9 more
doaj   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

Wiederherstellen der Proteinabbauwege im Hutchinson-Gilford Progerie Syndrom (HGPS) [PDF]

, 2019
The Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder that leads to death at an average age of 14.7 years. A point mutation within the lamin A gene results in the accumulation of a mutant protein called progerin.
Gabriel, Diana
core  

Autophagy Regulates Foxo1 Protein Abundance to Control Hepatic Glucose Production in Glucagon Signalling

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim During fasting, the liver undergoes coordinated metabolic adaptations to maintain systemic energy homeostasis. These adaptations are driven in part by glucagon, which promotes hepatic glucose production (HGP) and fatty acid oxidation (FAO) through mechanisms involving the transcription factor Foxo1.
Zheng Shen, Wanbao Yang, Quan Pan, Wen Jiang, Jeffrey Guo, Yuxiang Sun, Nicolaas Deutz, Bhimanagouda S. Patil, Pingwei Li, Shaodong Guo   +9 more
wiley   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source

Hutchinson-Gilford Progeria Syndrome (HGPS)

Journal of Oral Diagnosis, 2016
Hutchinson-Gilford Progeria Syndrome (HGPS) is an extremely rare genetic condition characterized by premature aging and it’s about one case for every four to eight million people. Children affected usually have premature death due to cardiovascular problems.
Alexandre Simoes Nogueira, Carlos Bruno Pinheiro Nogueira, Rômulo Medeiros, Ana Cristina Beviláqua, Paulo Sérgio da Silva Santos, Izabel Regina Fischer Rubira-Bullen, Eduardo Sanches Gonçales   +6 more
openaire   +1 more source

Fasting serum annexin A2 is associated with peripheral insulin sensitivity and may enhance glucose uptake via Src‐dependent signaling

Journal of Diabetes Investigation, EarlyView.
Circulating Annexin A2 is positively associated with peripheral insulin sensitivity. ABSTRACT Background and Aim Subcellular annexin A2 (ANXA2) is known to regulate membrane dynamics and GLUT4 trafficking in adipocytes; however, the role of serum ANXA2 in glucose metabolism remains unclear.
Yuichi Ito, Tsuyoshi Okura, Mari Anno, Sonoko Kitao, Satomi Endo, Yoshinori Ichihara, Tatsuya Sawano, Junichiro Miake, Etsuko Ueta, Masahiko Kato, Shin‐ichi Taniguchi, Kazuhiro Yamamoto, Takeshi Imamura   +12 more
wiley   +1 more source

Protecting CEACAM1 Expression Prevents Diet‐Induced Metabolic Dysfunction and Hepatic Fibrosis in Male Mice

Obesity, Volume 34, Issue 11, Page 2094-2108, November 2026.
ABSTRACT Objective High‐fat diet represses Ceacam1 transcription via a PPARα‐mediated mechanism to cause insulin resistance before inflammation develops. The current study investigated whether mutating PPRE‐RXRα in Ceacam1 promoter prevents diet‐induced metabolic abnormalities and hepatic fibrosis in male C57BL6/J mice.
Raziyeh Abdolahipour, Saja S. Khuder, William M. Philbrick, Agnes O. Portuphy, Getachew D. Belew, Hatem G. Fallouh, Harrison T. Muturi, Boyeon Kim, Jason K. Kim, Sonia M. Najjar   +9 more
wiley   +1 more source

Histidine Supplementation Stabilizes Hearing and Vision and Improves Growth in HARS1‐Related Autosomal Recessive Disorder Associated With Usher‐Like Symptoms

American Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2289-2308, October 2026.
ABSTRACT Autosomal recessive HARS1‐related disorder (originally described as Usher syndrome type 3B) caused by a homozygous Y454S variant in the histidyl‐tRNA synthetase gene (HARS1) is characterized by progressive sensorineural hearing and vision loss and respiratory deterioration with risk for sudden death following febrile illnesses.
Victoria Mok Siu, Rosan Kenana, Rana Chakrabarti, Sarah D. P. Wilhelm, Joseph Andrews, Susan J. Leat, Christina Parker, Michael Miller, Leslie A. Nangle, Wendy McCaul, Ashfia Chowdhury, Natalie Hutchings, Ryan A. Adams, Lauren Guy, Mandy Rhody, Verena Juncal, Marisa I. Mendes, Desiree E. C. Smith, Gajja S. Salomons, Angelica A. Moresco, Daphne L. McCulloch, D. Holmes Morton, Ilka U. Heinemann, C. Anthony Rupar   +23 more
wiley   +1 more source

Integrated Metabolomics and Network Pharmacology Reveal Anti‐Aging and Anti‐MRSA Activities of Cucumis melo Var. flexuosus

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
“Three fruit (LG, SH, and WH) and one leaves (LGLV) genotypes of snake melon were chemically profiled by LC‐HRMS. LGLV was chemically distinct and was active against MRSA as evidenced by an in vivo model. Moreover, LGLV counteracted H2O2‐induced cell senescence.
Mohammed N. A. Khalil, Rasha A. Radwan, Mariam Hassan, Noha A. Ahmed, Osama G. Mohamed, Mouchira A. Choucry, Ashootosh Tripathi, Rehab F. Taher   +7 more
wiley   +1 more source