Results 81 to 90 of about 4,214 (205)
The Journal of Physiology, Volume 604, Issue 20, Page 8523-8541, 15 October 2026.Abstract figure legend Skeletal muscle structure was analysed at three levels in young vs. aged humans, and in young vs. aged mice subjected to unilateral hindlimb immobilization to model disuse. (1) Macroscopic: magnetic resonance imaging of the thigh (human) and wet mass of individual hindlimb muscles (mouse) revealed that both ageing and disuse ...
Ramy K. A. Sayed +13 more
wiley +1 more source
A Wrinkle in Time: Premature Aging in HGPS and RD [PDF]
, 2008 The aging process can be accelerated by numerous cellular and molecular variables. Progeroid syndromes are one such example. The phenotypes of Hutchinson-Gilford Progeria Syndrome (HGPS) and Restrictive Dermopathy (RD) are both caused by an irregular ...
Fields, Nicole +4 more
core
Hydrology and geochemistry of a Hawaiian geothermal system: HGP-A [PDF]
, 1978 A water quality monitoring program of the Hawaii Geothermal Project well A (HGP-A) was conducted for downhole depth samples and continuous discharge samples in 1976 to 1977. The well water was slightly saline (about 5-10 percent ocean water) and nearly depleted of magnesium, but contained high concentrations of silica and sulfide.
Kroopnick, Peter M. +4 more
openaire +2 more sources
LivAge: An Online Aging Clock for Murine Transcriptomic Age Estimation
Aging Cell, Volume 25, Issue 9, September 2026.We present LivAge, an online aging clock that estimates murine transcriptomic age from hepatic RNA‐seq data. Externally validated, it detects accelerated aging in progeroid models and quantifies the effect of geroprotective interventions, providing an accurate, accessible, and ready‐to‐use tool for aging research.
Víctor Celemín‐Capaldi +6 more
wiley +1 more source
Temsirolimus does not impact DNA damage levels in HGPS cells.
, 2016 (A) Immunohistochemistry of control (GMO3349C) and HGPS (HGPSFN003) cells either mock-treated or treated with 1.0 μM temsirolimus for a period of 9 days. Antibodies against γH2A.X and 53BP1 were used (n = 4). Scale bar: 20 μm. (B) Immunohistochemistry of
Diana Gabriel (3608093) +2 more
core +1 more source
, 2018 Effect of incubation with SAMe on the premature-aging phenotype of HGPS cell lines. MTT-based proliferation assay (A) showing that periodic addition of SAMe to the culture media at a final concentration of 10 μg/mL, have a significant (p-value≤ 0.05 ...
Juan Fafián-Labora (5917748) +8 more
core +1 more source
BMC Medical Genomics, 2020 Background Parkinson’s Disease (PD) and Hutchinson-Gilford Progeria Syndrome (HGPS) are two heterogeneous disorders, which both display molecular and clinical alterations associated with the aging process.
Diana M. Hendrickx, Enrico Glaab
doaj +1 more source
Akkermansia muciniphila and Its Bioactive Derivatives: Emerging Regulators of Healthy Aging
Aging Cell, Volume 25, Issue 9, September 2026.The beneficial gut bacterium Akkermansia muciniphila (AKK) declines with age but is enriched in healthy centenarians. Supplementation of AKK extends healthspan and alleviates age‐related decline through direct host–microbe interactions and its bioactive derivatives, which collectively enhance gut barrier integrity, restore metabolic homeostasis ...
Ting Zhang +7 more
wiley +1 more source
Reductions in gammaH2AX response in HGPS cells are cell cycle dependent.
, 2016 (A). Representative fluorescence images of gammaH2AX foci and BrdU staining in middle passage normal and HGPS fibroblasts after Dox treatment. G0/G1 and S phase were indicated by BrdU negative and positive staining respectively. Scale Bar: 5um.
Celeste Witting (3372776) +6 more
core +1 more source
An Overview of Hutchinson Gilford Progeria Syndrome (HGPS)
British Journal of Medicine and Medical Research, 2015 Hutchinson Gilford Progeria Syndrome (HGPS) is a rare genetic disorder. The disorder is characterized by premature aging, generally leading to death. The purpose of this article is to review Hutchinson Gilford Progeria Syndrome and its characteristics.
Maria Tsiligiri +3 more
openaire +1 more source