Results 81 to 90 of about 7,722 (240)

Progerin Hinders Autophagy Flux at Its Final Stages in Hutchinson‐Gilford Progeria Syndrome Cells, Preventing Its Own Autophagic Degradation

Aging Cell, Volume 25, Issue 8, August 2026.
We demonstrated that progerin induces the formation of autophagosomes but impairs their maturation and subsequent fusion with lysosomes. Progerin impedes proper autophagy flux, thus preventing its own autophagic degradation. Selinexor treatment improved both autophagosome maturation and autophagosome‐lysosome fusion, which ultimately led to effective ...
Ian García‐Aguirre, Jesús Alejandro Reyes‐Martínez, Juan Unzueta, Francisco Guevara‐Namorado, Solangy Lizcano‐Meneses, Susana Gonzalo, Angel Baldan, Claudia Rangel, Gerardo J. Alanis‐Funes, Francisco Garcia‐Sierra, Kevin Ruiz‐Fajardo, Simon Gormes‐Pinchanski, Susana Castro‐Obregón, Aranza Meza‐Dorantes, Rocio Alejandra Chavez‐Santoscoy, Isabel Arrieta‐Cruz, Paola Tristán‐Aburto, Jonathan J. Magaña, Bulmaro Cisneros   +18 more
wiley   +1 more source

Weakened gammaH2AX leads to a delayed recruitment of non-homologous end joining (NHEJ) factors in G0/G1 HGPS cells. [PDF]

, 2016
(A). Representative fluorescence images of gammaH2AX foci and RIF1 foci in serum starvation synchronized middle passage normal and HGPS fibroblasts after Dox treatment. Arrow points to the single gammaH2AX or RIF1 foci in the enlarged square.
Celeste Witting (3372776), Haoyue Zhang (3372770), Linlin Sun (396058), Di Wu (23906), Kan Cao (454493), Kun Wang (134525), Mason Trappio (3372773)   +6 more
core   +1 more source

Artery‐on‐Chip Demonstrates Mechanical and Functional Features of Healthy and Diseased Living Smooth Muscle Tissue

Advanced Functional Materials, Volume 36, Issue 59, 23 July 2026.
This article details the development of an artery‐on‐chip platform for in vitro arterial disease modeling and therapeutic discovery. It describes the fabrication of a fibrin biomaterial scaffold seeded with iPSC‐derived smooth muscle and endothelial cells, mimicking native artery properties. Two genetic disease models showcase the platform's ability to
Danielle Yarbrough, Roy Chen, Katerina Katsouleas, Jaron Shoemaker, Travis Brady, Tianfang Yu, Jennifer Arthur Ataam, Connor Amelung, Lakshmi Santhanam, Ioannis Karakikes, Sharon Gerecht   +10 more
wiley   +1 more source

Multiscale Architecture and Mechanics of the Cell Nucleus: Implications for Disease, Bioengineering and Nanomedicine

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu, Xin Chen, Qingyang Zhao, Weikang Tan, Lingrui Zhu, Kin Liao, Vincent Chan, Nicolae Goga, Winfred O. Larkotey, Yang Li, Yinghui Shi, Wenya Shu, Lin Wang, Weiqing Wang, Tian Jian Lu, Yulong Han   +15 more
wiley   +1 more source

Nuclear softening mediated by Sun2 suppression delays mechanical stress-induced cellular senescence

Cell Death Discovery, 2023
Nuclear decoupling and softening are the main cellular mechanisms to resist mechanical stress-induced nuclear/DNA damage, however, its molecular mechanisms remain much unknown.
Xianlin Yue, Jie Cui, Zewei Sun, Lei Liu, Y. Li, Liwei Shao, Qingwen Feng, Ziyue Wang, W. S. Hambright, Yan Cui, J. Huard, Y. Mu, Xiaodong Mu   +12 more
semanticscholar   +1 more source

Nuclear dysfunction in aging and neurodegeneration

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract Neurodegenerative diseases are characterized by a loss of neuronal function and structure, often in a region‐specific manner. Multiple factors contribute to neuronal dysfunction and death, including pathogenic protein buildup, protein mislocalization, and inflammation. Despite extensive research, the common mechanisms driving neurodegeneration
Abbigael Aday, Jack Tiller, Adarsh Melukote, Zachary C. Walton, Anna King, Luke Castillo, Rakez Kayed, Mauro Montalbano   +7 more
wiley   +1 more source

Hyaluronic Acid-Based Hydrogels: from a Natural Polysaccharide to Complex Networks

Soft Matter, 2012
Hyaluronic acid (HA) is one of nature's most versatile and fascinating macromolecules. Being an essential component of the natural extracellular matrix (ECM), HA plays an important role in a variety of biological processes.
Xian Xu, A. Jha, D. Harrington, M. Farach-Carson, Xinqiao Jia   +4 more
semanticscholar   +1 more source

SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson–Gilford progeria syndrome

Cell Death and Disease, 2022
Hutchinson–Gilford progeria syndrome (HGPS) is a rare, fatal disease caused by Lamin A mutation, leading to altered nuclear architecture, loss of peripheral heterochromatin and deregulated gene expression.
Giorgia Catarinella, Chiara Nicoletti, Andrea Bracaglia, Paola Procopio, Illari Salvatori, Marilena Taggi, Cristiana Valle, Alberto Ferri, Rita Canipari, Pier Lorenzo Puri, Lucia Latella   +10 more
doaj   +1 more source

Frequency of Insulin Resistance in Overweight Patients With Metabolic‐Associated Fatty Liver Disease (MAFLD) at a Tertiary Healthcare Centre in Bangladesh

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
Among overweight, non‐diabetic MAFLD patients at a Bangladeshi tertiary centre, 60% had insulin resistance (median HOMA‐IR: 2.85). Acanthosis nigricans significantly correlated with higher HOMA‐IR (5.79 vs. 2.89). No significant correlation existed between HOMA‐IR and BMI, METS‐IR, or TG/HDL‐c ratio.
Md. Mohiuddin Rozaik, Md. Kawsar Uddin, Syed Azmal Mahmood, Sadia Islam Sukonna, Tasnim Nafian, Kazi Ali Aftab, Khaled Mahbub Murshed, Md Abul Kalam Azad   +7 more
wiley   +1 more source

Derivation and Characterization of Pax7 Positive Skeletal Muscle Precursor Cells from Control and HGPS-derived induced Pluripotent Stem Cells [PDF]

, 2018
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic disorder associated with premature aging in various tissues and organs of the afflicted individuals, including accelerated skeletal muscle atrophy.
Kocharyan, Avetik
core   +1 more source