Results 81 to 90 of about 4,130 (205)
COMPUTATIONAL INVESTIGATION OF TRANSCRIPTOMIC AND GENETIC UNDERPINNINGs OF AGING AND HGPS [PDF]
, 2018 Normal aging is a complex process affecting everyone, and also a major risk factor for many complex diseases. Hutchinson Gilford progeria syndrome (HGPS) is a rare genetic disease with symptoms of aging at a very early age. There are some known and other
Wang, Kun
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Hawaii Geothermal Project; HGP-A Reservoir Engineering [PDF]
, 1978 Department of Energy, Contract EY-76-C-03-1093; Energy Research and Development Administration, Contract E(04-3)-1093; National Science Foundation, Grant GI 38319; State of Hawaii, Grants RCUH 5774, 5784, 5942; County of Hawaii, Grant RCUH 5773; Hawaiian Electric Company, Grants 5809, 5828.
Yuen, P. C. +4 more
openaire +2 more sources
Advanced Science, Volume 13, Issue 37, 3 July 2026.Nuclear mechanical properties are inherently scale‐dependent, arising from a hierarchical architecture that spans DNA, chromatin, the nuclear envelope, and condensates. Experimental techniques and theoretical models are integrated into a cohesive multiscale framework linking nanoscale structural features to organelle‐level mechanical behavior.
Xinran Liu +15 more
wiley +1 more source
, 2018 Effect of incubation with SAMe on the premature-aging phenotype of HGPS cell lines. MTT-based proliferation assay (A) showing that periodic addition of SAMe to the culture media at a final concentration of 10 μg/mL, have a significant (p-value≤ 0.05 ...
Juan Fafián-Labora (5917748) +8 more
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An Overview of Hutchinson Gilford Progeria Syndrome (HGPS)
British Journal of Medicine and Medical Research, 2015 Hutchinson Gilford Progeria Syndrome (HGPS) is a rare genetic disorder. The disorder is characterized by premature aging, generally leading to death. The purpose of this article is to review Hutchinson Gilford Progeria Syndrome and its characteristics.
Maria Tsiligiri +3 more
openaire +1 more source
Are There Common Mechanisms Between the Hutchinson–Gilford Progeria Syndrome and Natural Aging?
Frontiers in Genetics, 2019 The Hutchinson–Gilford progeria syndrome (HGPS) is a premature aging disease caused by mutations of the LMNA gene leading to increased production of a partially processed form of the nuclear fibrillar protein lamin A – progerin.
Vasily V. Ashapkin +3 more
doaj +1 more source
Differential stem cell aging kinetics in Hutchinson-Gilford progeria syndrome and Werner syndrome
Protein & Cell, 2018 Hutchinson-Gilford progeria syndrome (HGPS) and Werner syndrome (WS) are two of the best characterized human progeroid syndromes. HGPS is caused by a point mutation in lamin A (LMNA) gene, resulting in the production of a truncated protein product ...
Zeming Wu +14 more
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, 2016 (A). Representative fluorescence images of gammaH2AX foci in serum starvation synchronized middle passage normal and HGPS fibroblasts after Dox treatment. Arrow points to the single gammaH2AX foci in the enlarged square. Scale Bar: 5um. (B). Line profile
Celeste Witting (3372776) +6 more
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, 2016 (A). Representative fluorescence images of gammaH2AX foci and RIF1 foci in serum starvation synchronized middle passage normal and HGPS fibroblasts after Dox treatment. Arrow points to the single gammaH2AX or RIF1 foci in the enlarged square.
Celeste Witting (3372776) +6 more
core +1 more source
Impact of miR-181a on SIRT1 Expression and Senescence in Hutchinson–Gilford Progeria Syndrome
DiseasesBackground/Objectives: Hutchinson–Gilford progeria syndrome (HGPS) is a rare and fatal genetic disease caused by a silent mutation in the LMNA gene, leading to the production of progerin, a defective prelamin A variant.
Eva-Maria Lederer +5 more
doaj +1 more source