Results 101 to 110 of about 4,130 (205)
Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome
Nature Communications, 2018 Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, but devastating genetic disease characterized by segmental premature aging, with cardiovascular disease being the main cause of death.
Gabriel Balmus +17 more
doaj +1 more source
Expression of TRP channel transcripts in IMR90-iPSC-ECs and HGPS-iPSC-ECs.
, 2014 Shown were the expressional levels of transcripts for TRPV (A), TRPC (B), TRPM (C) and TRPP (D) in IMR90-iPSC-ECs (I) and HGPS-iPSC-ECs (H).
Nelson L. Tang (515416) +8 more
core +1 more source
Expression of TRPV2 proteins in IMR90-iPSC-ECs and HGPS-iPSC-ECs.
, 2014 (A and B), representative images (A) and data summary (B) of TRPV2 protein expression in IMR90- and HGPS-iPSC-ECs.
Nelson L. Tang (515416) +8 more
core +1 more source
The Geochemistry of the HGP-A Geothermal Well: A Review and an Update [PDF]
, 1988 The HGP-A geothermal well, located on the lower east rift system of Kilauea volcano, has provided steam and hot water to a 3 MWe wellhead generator facility on a continuous basis since December 1981.
openaire +2 more sources
, 2018 Volcano plot representations of the RNAseq (A) and shotgun proteomics (B) analysis of the HGPS and Control cell lines. For RNAseq, a threshold of q-value = 0.05 was set for significance according the statistical package used for analysis.
Juan Fafián-Labora (5917748) +8 more
core +1 more source
, 2018 Representation of the modulation in HGPS versus Control cell lines of the transcripts detected as significant and those correlating with the proteomic approach (red dots in A).
Juan Fafián-Labora (5917748) +8 more
core +1 more source
Temsirolimus does not impact the levels of reactive oxygen species and superoxide in HGPS cells.
, 2016 (A) Immunochemistry was performed on control (GMO3349C) and HGPS (HGADFN003) fibroblasts mock-treated or temsirolimus-treated for the indicated periods. Live cells were stained with an oxidative stress detection reagent for ROS and a superoxide detection
Diana Gabriel (3608093) +2 more
core +1 more source
, 2013 A, HGPS skin sections immunostained with anti-progerin (prog), anti-lamin A (LMNA) antibody, or anti-α smooth muscle actin antibody (αSMA) and counterstained with a DNA stain (dapi).
Desiree Ratner (82177) +6 more
core +1 more source
Accelerated atherosclerosis in HGPS
Aging, 2018 Hamczyk, Magda R., Andres, Vicente
openaire +3 more sources
Proposed model to explain the down-regulation of PRPS1 in HGPS.
, 2018 Enzymes in blue are detected as down-regulated and those in red as up-regulated in the present study. High glycolitic rate in HGPS drives to a decrease in the levels of D-Ribose-5-phosphate available for de novo purine synthesis.
Juan Fafián-Labora (5917748) +8 more
core +1 more source