Results 101 to 110 of about 5,892 (251)
Frontiers in Immunology, 2022 BackgroundHistopathological growth patterns (HGPs) have shown important prognostic values for patients with colorectal cancer liver metastases, but the potential molecular mechanisms remain largely unknown.MethodsWe performed an exploratory analysis by ...
Mingtao Hu +40 more
doaj +1 more source
Thoracic Cancer, Volume 17, Issue 8, April 2026.We developed CEHS, a novel multiparameter model integrating radiological, molecular, and pathological features, which outperforms TNM staging and existing grading systems in predicting recurrence‐free survival for patients with pathological stage I lung adenocarcinoma.
Hui Zeng +15 more
wiley +1 more source
SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson–Gilford progeria syndrome
Cell Death and Disease, 2022 Hutchinson–Gilford progeria syndrome (HGPS) is a rare, fatal disease caused by Lamin A mutation, leading to altered nuclear architecture, loss of peripheral heterochromatin and deregulated gene expression.
Giorgia Catarinella +10 more
doaj +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 8, April 2026.ABSTRACT CRISPR‐Cas9 systems revolutionized gene editing, but inherent drawbacks, namely DNA double‐strand breaks (DSBs) and the difficulty of achieving precise repairs (due to low HDR efficiency), led researchers to invent new, more accurate gene editing tools.
Melike Aliciaslan +3 more
wiley +1 more source
HGP-write : après la lecture, l’écriture ? [PDF]
médecine/sciences, 2016 The recently proposed « HGP-write » project aims to synthetize a full human genome and to introduce it into cells. This ambitious endeavour is fraught with financial and technical uncertainties and, if successful, would make « synthetic humans » a definite possibility even though this is not part of its announced goals.
openaire +2 more sources
Diabetes/Metabolism Research and Reviews, Volume 42, Issue 3, March 2026.ABSTRACT Recent evidence has shown that muscle insulin resistance is not the only factor contributing to type 2 diabetes (T2D). Organ‐specific insulin resistance is increasingly recognised as a significant contributor to the metabolic changes that lead to hyperglycemia, although the precise extent of its impact remains unclear.
Shawn Gugliandolo +13 more
wiley +1 more source
DNA Methylation Signatures of Cellular Senescence Are Not Reversed by Senolytic Treatment
Aging Cell, Volume 25, Issue 3, March 2026.We found very little overlap between CpGs that were correlated with in vitro senescence, chronological age, and mortality. While we were able to train epigenetic clocks with CpGs that accelerated with cellular senescence, these clocks did not decelerate with Senolytic treatment. ABSTRACT Epigenetic clocks are commonly used aging biomarkers based on DNA
Jessica Kasamoto +7 more
wiley +1 more source
Large-scale Heteroscedastic Regression via Gaussian Process
, 2020 Heteroscedastic regression considering the varying noises among observations has many applications in the fields like machine learning and statistics.
Cai, Jianfei, Liu, Haitao, Ong, Yew-Soon
core +1 more source
Vessel co-option mediates resistance to anti-angiogenic therapy in liver metastases [PDF]
, 2016 The efficacy of angiogenesis inhibitors in cancer is limited by resistance mechanisms that are poorly understood. Notably, instead of through the induction of angiogenesis, tumor vascularization can occur through the nonangiogenic mechanism of vessel co ...
Berg, TJ +30 more
core +3 more sources
Journal of the American Geriatrics Society, Volume 74, Issue 3, Page 760-769, March 2026.This study globally shows that the EWGSOP2 algorithm is a valid tool even in hospitalized older patients. In fact, every step enhances the predictive validity of the algorithm, suggesting, however, that SARC‐F and muscle strength can still be valuable tools for negative clinical outcomes when body composition data are not available.
Elena Zoico +7 more
wiley +1 more source