Results 91 to 100 of about 5,892 (251)

Genetics and Genomics in Sickle Cell Disease in Africa

American Journal of Hematology, Volume 101, Issue S1, Page 47-55, April 2026.
ABSTRACT Advanced genomic technologies are revolutionizing our ability to understand complex diseases. Large‐scale population studies are needed to realize the potential of using individual genetic information to personalize treatments for better patient outcomes for chronic non‐communicable diseases, such as sickle cell disease (SCD).
Siana Nkya, Julie Makani, Jonathan M. Flanagan   +2 more
wiley   +1 more source

Direct reprogramming of human smooth muscle and vascular endothelial cells reveals defects associated with aging and Hutchinson-Gilford progeria syndrome

eLife, 2020
Vascular dysfunctions are a common feature of multiple age-related diseases. However, modeling healthy and pathological aging of the human vasculature represents an unresolved experimental challenge. Here, we generated induced vascular endothelial cells (
Simone Bersini, Roberta Schulte, Ling Huang, Hannah Tsai, Martin W Hetzer   +4 more
doaj   +1 more source

Discovery of new TeV supernova remnant shells in the Galactic plane with H.E.S.S

, 2016
Supernova remnants (SNRs) are prime candidates for efficient particle acceleration up to the knee in the cosmic ray particle spectrum. In this work we present a new method for a systematic search for new TeV-emitting SNR shells in 2864 hours of H.E.S.S ...
Capasso, M., Deil, C., Djannati-Atai, A., Donath, A., Eger, P., Gottschall, D., Marandon, V., Maxted, N., Pühlhofer, G., Renaud, M., Sasaki, M., Terrier, R., Vink, J.   +12 more
core   +3 more sources

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source

Knowledge, Attitude, and Perception of Nursing Students in Selected Private Universities on Integration of Genomic Information Into Clinical Assessment and Patient Education: A Descriptive Cross‐Sectional Survey

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims The rapid growth of genomics in healthcare has led to significant advances, and the integration of genetic information into clinical and patient education among nursing students during their training years is crucial to equip them for the genomic era.
Iyanuoluwa Oreofe Ojo, Toluwanimi Anuoluwapo Asumo, Ajibola Omobola Ojo, Prisca Olabisi Adejumo   +3 more
wiley   +1 more source

Epithelial stem cells In Hutchinson-Gilford progeria syndrome [PDF]

, 2015
Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) are two rare genetic disorders that affect children. Complications from cardiovascular disease, including atherosclerosis, are the most common cause of death in HGPS, which ...
McKenna, Tomás
core   +1 more source

Murine Progeria Model Exhibits Delayed Fracture Healing With Senescent Phenotype and Dysregulated Immune Response

Journal of Orthopaedic Research, Volume 44, Issue 4, April 2026.
Graphical Abstract This study explores whether a murine model of progeria has a delayed fracture healing phenotype that resembles chronological aging but with an accelerated timeline that could make it a valuable research tool. ABSTRACT An estimated 189 million bone fractures occurred in 2019 making it one of the most globally prevalent injuries ...
Victoria R. Duke, Marc J. Philippon Jr., Dane R. G. Lind, Herbert Kasler, Kohei Yamaura, Matt Huard, Molly Czachor, Justin Hollenbeck, Justin Brown, Alex Garcia, Jacob D. Matityahu, Naomasa Fukase, Ralph S. Marcucio, Anna‐Laura Nelson, William S. Hambright, Dustin M. Snapper, Johnny Huard, Chelsea S. Bahney   +17 more
wiley   +1 more source

Organic Transistor‐Based Neuromorphic Electronics and Their Recent Applications

Small Methods, Volume 10, Issue 7, 6 April 2026.
This review highlights recent progress in organic neuromorphic electronics, showing how organic semiconductors enable synaptic and neuronal functions with low power, mechanical flexibility, and biocompatibility. By bridging materials, devices, and systems, organic platforms are accelerating brain‐inspired computing toward applications in artificial ...
Ziru Wang, Feng Yan
wiley   +1 more source

A probabilistic data-driven model for planar pushing

, 2017
This paper presents a data-driven approach to model planar pushing interaction to predict both the most likely outcome of a push and its expected variability.
Bauza, Maria, Rodriguez, Alberto
core   +1 more source

HPoolGCL: Augmentation‐Free Cross‐Granularity Graph Contrastive Learning With Hierarchical Pooling

CAAI Transactions on Intelligence Technology, Volume 11, Issue 2, Page 610-632, April 2026.
ABSTRACT Graph contrastive learning (GCL) has emerged as a dominant paradigm for self‐supervised representation learning for attributed graph data. However, existing GCL methods heavily rely on empirical graph data augmentation, which may distort intrinsic graph semantics and produce poor generalisation without carefully chosen or designed augmentation
Fenglin Cen, Shijie Liu, Quan Feng, Tiantian He, Ji Xu   +4 more
wiley   +1 more source