Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers
MedComm, Volume 7, Issue 7, July 2026.This schematic illustrates the hierarchical and interconnected nature of the primary molecular hallmarks of aging. The progression of aging is driven by a convergence of intrinsic molecular insults. Within the nucleus, genomic instability and telomere attrition trigger persistent DDR, accompanied by extensive epigenetic alterations.
Guowei Cai +10 more
wiley +1 more source
Hutchinson Gilford Progeria Syndrome (HGPS): Potential Treatments [PDF]
, 2018 The Hutchinson-Gilford Progeria syndrome is a rare genetic disease that causes an early accelerated aging in children; clinically characterized by manifestations affecting skin, musculoskeletal system and blood vessels, also other features supporting ...
Sutiono, D. R. (Dias) +1 more
core
De HGP-write aux « super-cellules » [PDF]
médecine/sciences, 2018 The HGP-write project, announced in 2016 but not really implemented yet, comes back as a project aimed at constructing an “ultra-safe” human cell line fully resistant to virus infection and with other desirable characteristics. This involves introducing 400,000 changes in the genome and raises a number of technical and financial issues, but may become ...
openaire +2 more sources
Metabolic Dysfunction‐Associated Fatty Liver Disease: From Pathogenesis to Treatment
MedComm, Volume 7, Issue 7, July 2026.Extracellular vesicles play a crucial role in interorgan crosstalk of adipose–liver and gut–liver axes and hold potential as therapeutic targets and drug delivery systems for metabolic dysfunction‐associated fatty liver disease (MAFLD). Abbreviations: AT: adipose tissue; EVs: extracellular vesicles; HL: healthy liver; NAFL: nonalcoholic fatty liver ...
Zhifu Cui +5 more
wiley +1 more source
Hutchinson-Gilford Progeria Syndrome: a premature aging disease caused by LMNA gene mutations
Ageing Research Reviews, 2016 Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is essential for proper nuclear architecture.
S. Gonzalo, R. Kreienkamp, P. Askjaer
semanticscholar +1 more source
Targeted validation of PRPS1 shows down-regulation of transcript and protein levels in HGPS-cells and the animal model of HPGS, respectively. [PDF]
, 2018 Orthogonal validation of PRPS1 modulation by targeted techniques in cell lines (A, B) and in the mouse model of HGPS (C, D). Real-Time PCR (RT-PCR) of HGPS and control cell lines (A) showing that PRPS1 transcript is down-regulated in the three HGPS cell ...
Juan Fafián-Labora (5917748) +8 more
core +1 more source
Low levels of the reverse transactivator fail to induce target transgene expression in vascular smooth muscle cells. [PDF]
PLoS ONE, 2014 Hutchinson-Gilford progeria syndrome (HGPS) is a genetic disease with multiple features that are suggestive of premature aging. Most patients with HGPS carry a mutation on one of their copies of the LMNA gene.
Nikenza Viceconte +2 more
doaj +1 more source
Hawaii Geothermal Project; HGP-A Reservoir Engineering [PDF]
, 1978 Department of Energy, Contract EY-76-C-03-1093; Energy Research and Development Administration, Contract E(04-3)-1093; National Science Foundation, Grant GI 38319; State of Hawaii, Grants RCUH 5774, 5784, 5942; County of Hawaii, Grant RCUH 5773; Hawaiian Electric Company, Grants 5809, 5828.
Yuen, P. C. +4 more
openaire +2 more sources
Nucleolar expansion and elevated protein translation in premature aging
Nature Communications, 2017 Premature aging disorders provide an opportunity to study the mechanisms that drive aging. In Hutchinson-Gilford progeria syndrome (HGPS), a mutant form of the nuclear scaffold protein lamin A distorts nuclei and sequesters nuclear proteins. We sought to
A. Buchwalter, M. Hetzer
semanticscholar +1 more source
Expression of TRP channel transcripts in IMR90-iPSC-ECs and HGPS-iPSC-ECs. [PDF]
, 2014 Shown were the expressional levels of transcripts for TRPV (A), TRPC (B), TRPM (C) and TRPP (D) in IMR90-iPSC-ECs (I) and HGPS-iPSC-ECs (H).
Nelson L. Tang (515416) +8 more
core +1 more source