Results 91 to 100 of about 4,130 (205)

HGP-A wellhead generator proof-of-feasibility project [PDF]

, 1978
The HGP-A Wellhead Generator Proof-of-Feasibility Project consists of a nominal 3 Megawatt geothermal steam turbine electric power generating facility, the first geothermal power plant in Hawaii. The plant is being constructed as a research and development project to evaluate geothermal steam as a viable resource to be considered for larger commercial ...
openaire   +2 more sources

Chromosome territory position and active relocation in normal and hutchinson-gilford progeria fibroblasts [PDF]

, 2009
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Radial chromosome positioning in interphase nuclei is non-random and can alter according to developmental, differentiation, proliferation or disease status.
Mehta, Ishita Shailesh
core   +4 more sources

Adenine base editing rescues pathogenic phenotypes in tissue engineered vascular model of Hutchinson-Gilford progeria syndrome

APL Bioengineering
The rare, accelerated aging disease Hutchinson-Gilford Progeria Syndrome (HGPS) is commonly caused by a de novo c.1824 C > T point mutation of the LMNA gene that results in the protein progerin.
Nadia O. Abutaleb, Xin D. Gao, Akhil Bedapudi, Leandro Choi, Kevin L. Shores, Crystal Kennedy, Jordyn E. Duby, Kan Cao, David R. Liu, George A. Truskey   +9 more
doaj   +1 more source

Fact sheet for the Hawaii Geothermal Project (HGP) [PDF]

, 1976
This fact sheet for distribution at the flash and flow test of HGP-A, July 22, 1976 contains a temperature-depth plot, a brief chronology, and a budget summary. (MHR)
openaire   +2 more sources

Inhibition of JAK-STAT Signaling with Baricitinib Reduces Inflammation and Improves Cellular Homeostasis in Progeria Cells

Cells, 2019
Hutchinson-Gilford progeria syndrome (HGPS), a rare premature aging disorder that leads to death at an average age of 14.7 years due to myocardial infarction or stroke, is caused by mutations in the LMNA gene.
Chang Liu, Rouven Arnold, Gonçalo Henriques, Karima Djabali   +3 more
doaj   +1 more source

Hutchinson Gilford Progeria Syndrome (HGPS): Potential Treatments

, 2018
The Hutchinson-Gilford Progeria syndrome is a rare genetic disease that causes an early accelerated aging in children; clinically characterized by manifestations affecting skin, musculoskeletal system and blood vessels, also other features supporting ...
Sutiono, D. R. (Dias), Adeline, F. (Fransiska)   +1 more
core  

Derivation and Characterization of Pax7 Positive Skeletal Muscle Precursor Cells from Control and HGPS-derived induced Pluripotent Stem Cells

, 2018
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic disorder associated with premature aging in various tissues and organs of the afflicted individuals, including accelerated skeletal muscle atrophy.
Kocharyan, Avetik
core   +1 more source

The Human Genome Project (HGP): dividends and challenges: a review.

Journal of College of Medicine, 2012
Background: Many disorders in man have been described as genetic or hereditary in nature and have defied absolute medical treatment and cure. Genomic studies have given profound insights into the genetic organization of many organisms including man.
openaire   +3 more sources

Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria

eLife, 2015
Hutchinson-Gilford progeria (HGPS) is a premature ageing syndrome caused by a mutation in LMNA, resulting in a truncated form of lamin A called progerin.
Alexandre Chojnowski, Peh Fern Ong, Esther SM Wong, John SY Lim, Rafidah A Mutalif, Raju Navasankari, Bamaprasad Dutta, Henry Yang, Yi Y Liow, Siu K Sze, Thomas Boudier, Graham D Wright, Alan Colman, Brian Burke, Colin L Stewart, Oliver Dreesen   +15 more
doaj   +1 more source

Targeted validation of PRPS1 shows down-regulation of transcript and protein levels in HGPS-cells and the animal model of HPGS, respectively.

, 2018
Orthogonal validation of PRPS1 modulation by targeted techniques in cell lines (A, B) and in the mouse model of HGPS (C, D). Real-Time PCR (RT-PCR) of HGPS and control cell lines (A) showing that PRPS1 transcript is down-regulated in the three HGPS cell ...
Juan Fafián-Labora (5917748), María C. Arufe (5917763), Iván Lesende-Rodriguez (5917754), Lorenzo Monserrat (2622139), Miriam Morente-López (5917751), María A. Ódena (5917757), Javier de Toro (5917760), Jesús Mateos (4634137), Eliandre de Oliveira (1816573)   +8 more
core   +1 more source