Results 71 to 80 of about 4,214 (205)

Truncated prelamin A expression in HGPS-like patients: a transcriptional study

, 2015
Contains fulltext : 154354.pdf (Publisher’s version ) (Closed access)Premature aging syndromes are rare genetic disorders mimicking clinical and molecular features of aging.
Evangeliou, Athanasios E., Roll, Patrice, Silva, N., Bartoli, Marc, Nicolas Lévy, Spilioti, Martha, Sigaudy, S., Nathalie Da Silva, Evangeliou, A.E., Fayek, R., Florian Barthélémy, Wevers, R.A., Navarro, C, Roll, P., Oshima, Junko, Papadopoulou-Legbelou, K., Andrée Robaglia-Schlupp, Ron A Wevers, Robaglia-Schlupp, Andrée, Marc Bartoli, Navarro, Claire, Fayek, Racha, Wevers, Ron A., Lévy, Nicolas, Martha Spilioti, Kyriaki Papadopoulou-Legbelou, Sabine Sigaudy, Sandre-Giovannoli, A. De, Athanasios E Evangeliou, Wevers, Ron A, Sigaudy, Sabine, Oshima, J., Spilioti, M., Gisèle Bonne, Barthelemy, Florian, Papadopoulou-Legbelou, Kyriaki, Junko Oshima, Morava, E., Martine Lemerrer, Claire Navarro, Racha Fayek, Bonne, Gisèle, Evangeliou, Eva, Bonne, G., da Silva, Nathalie, Bartoli, M., Barthelemy, F., de Sandre-Giovannoli, Annachiara, Eva Morava, Lemerrer, M., Lemerrer, Martine, Morava, Eva, Annachiara De Sandre-Giovannoli, Navarro, Claire, L., Patrice Roll, Levy, N., Robaglia-Schlupp, A.   +56 more
core   +1 more source

Liver Metastases from Colorectal Cancer: From Pathogenesis to Current Treatment

MedComm, Volume 7, Issue 10, October 2026.
The liver is not merely a passive recipient of disseminated tumor cells, but a unique metastatic organ shaped by anatomical, metabolic, and immunological characteristics that support tumor colonization. Increasing evidence indicates that colorectal cancer liver metastasis development is driven by dynamic interactions between tumor intrinsic programs ...
Jialiang Fan, Huiru Zhang, Deyang Kong, Yu Sun, Shuaibing Lu, Wenjing Yang, Renshen Xiang, Qi Zhang, Wei Pei, Haizeng Zhang, Lin Feng   +10 more
wiley   +1 more source

Loss of H3K9me3 correlates with impaired ATM activation in HGPS.

, 2016
(A). Representative fluorescence images of gammaH2AX and H3K9me3 in middle passage normal and HGPS fibroblasts after Dox treatment. “Low H3K9me3” is defined as any H3K9me3 fluorescence intensity that falls below the lower 5% of the normal population ...
Celeste Witting (3372776), Haoyue Zhang (3372770), Linlin Sun (396058), Di Wu (23906), Kan Cao (454493), Kun Wang (134525), Mason Trappio (3372773)   +6 more
core   +1 more source

De HGP-write aux « super-cellules » [PDF]

médecine/sciences, 2018
The HGP-write project, announced in 2016 but not really implemented yet, comes back as a project aimed at constructing an “ultra-safe” human cell line fully resistant to virus infection and with other desirable characteristics. This involves introducing 400,000 changes in the genome and raises a number of technical and financial issues, but may become ...
openaire   +2 more sources

SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson–Gilford progeria syndrome

Cell Death and Disease, 2022
Hutchinson–Gilford progeria syndrome (HGPS) is a rare, fatal disease caused by Lamin A mutation, leading to altered nuclear architecture, loss of peripheral heterochromatin and deregulated gene expression.
Giorgia Catarinella, Chiara Nicoletti, Andrea Bracaglia, Paola Procopio, Illari Salvatori, Marilena Taggi, Cristiana Valle, Alberto Ferri, Rita Canipari, Pier Lorenzo Puri, Lucia Latella   +10 more
doaj   +1 more source

The Underexplored Mechanobiology of Lamin A Biogenesis and Homeostasis

Biology of the Cell, Volume 118, Issue 10, October 2026.
We highlight current evidence, unresolved questions, and future directions, proposing that mechanical regulation of lamin A biogenesis represents an underexplored dimension of lamin mechanobiology with broad implications for development, aging, laminopathies, and mechanically driven diseases. ABSTRACT Lamin A is a major contributor to nuclear mechanics
Sandrine Fraboulet, Omar Aldarawish, Monika Elzbieta Dolega   +2 more
wiley   +1 more source

Eco‐Evolutionary Feedback to a Pesticide Worsens the Impact of a Pesticide Switch in a Pivotal Freshwater Non‐Target Species

Ecology Letters, Volume 29, Issue 10, October 2026.
Selection under the insecticide chlorpyrifos strongly affected the genetic makeup of non‐target Daphnia magna populations and increased tolerance of chlorpyrifos‐selected populations to chlorpyrifos and malathion (same mode of action as chlorpyrifos) but reduced performance when exposed to deltamethrin (different mode of action from chlorpyrifos).
Rafaela A. Almeida, Maxime Fajgenblat, Pieter Lemmens, Kiani Cuypers, Jade Maes, Kristien I. Brans, Luc De Meester   +6 more
wiley   +1 more source

Temsirolimus does not impact HGPS mitochondrial dysfunction.

, 2016
(A) Immunohistochemistry was performed on mock-treated or temsirolimus-treated control (GMO3349C) and HGPS (HGADFN003) fibroblasts (9 days of treatment). Antibodies against NADPH oxidase subunit 4 (Nox4) and progerin were used.
Diana Gabriel (3608093), Karima Djabali (82182), Leslie B. Gordon (82180)   +2 more
core   +1 more source

ZmDLR9 is required for lateral root development via pre‐rRNA processing in maize

The Plant Journal, Volume 128, Issue 1, October 2026.
SUMMARY Pumilio (PUM) proteins comprise an evolutionarily conserved family of sequence‐specific RNA‐binding proteins that act as key post‐transcriptional regulators in eukaryotes. In this study, we identified a maize PUM protein, named ZmDLR9 (Defective in Lateral Root 9), as a positive factor involved in lateral root development.
Daojun Li, Yang Li, Aiming Xing, Shixian Zhang, Yanbin Zhu, Feng Wei, Haitao Zeng, Tao Zheng, Zhubing Hu, Chunfei Wang   +9 more
wiley   +1 more source

HGPS fibroblasts show reduced gammaH2AX response upon Dox treatment.

, 2016
(A) Representative fluorescence images of gammaH2AX foci in middle passage normal and HGPS fibroblasts after Dox treatment. Scale Bar: 5um. (B).
Celeste Witting (3372776), Haoyue Zhang (3372770), Linlin Sun (396058), Di Wu (23906), Kan Cao (454493), Kun Wang (134525), Mason Trappio (3372773)   +6 more
core   +1 more source