Results 71 to 80 of about 4,130 (205)

Estrogen Receptor Beta Activation Coordinates Liver Lipid Remodeling and Metabolic Fluxes, Preventing Lipotoxicity

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
ERβ activation restores glucose and lipid homeostasis by remodeling the hepatic lipidome. Mechanistically, it promotes complete fatty acid oxidation and decreases Acetyl‐CoA levels, leading to reduced ketogenesis and lipotoxicity, as demonstrated through in vivo and in vitro approaches.
Debora Santos Rocha, Eloisa Vilas‐Boas, Camille C. Caldeira da Silva, Everton L. Vogt, Marcos Yoshinaga, Mariana Pacheco Teixeira de Carvalho, Maiara I. C. Queiroz, Tiago Eugênio Oliveira da Silva, Sayuri Miyamoto, Alicia J. Kowaltowski   +9 more
wiley   +1 more source

Type 2 Diabetes Mellitus: Molecular Pathogenesis and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
This graphical summary illustrates the multiorgan therapeutic landscape for Type 2 diabetes mellitus (T2D), integrating molecular pathogenesis with modern treatment strategies. It depicts how current interventions, including SGLT2 inhibitors, GLP‐1 receptor agonists, and insulin secretagogues, target key organs—kidney, pancreas, gastrointestinal tract,
Shinuan Fei, Xiyue Xiong, Lu Zhang, Jian Zhang, Lawrence W. C. Chan, Hong Jiang, Qingqing Xiong, Changtao Hu, Jie Chen, Sijun Yang   +9 more
wiley   +1 more source

Hydrology and geochemistry of a Hawaiian geothermal system: HGP-A [PDF]

, 1978
A water quality monitoring program of the Hawaii Geothermal Project well A (HGP-A) was conducted for downhole depth samples and continuous discharge samples in 1976 to 1977. The well water was slightly saline (about 5-10 percent ocean water) and nearly depleted of magnesium, but contained high concentrations of silica and sulfide.
Kroopnick, Peter M., Buddemeier, Robert W., Thomas, Donald M., Lau, L. Stephen, Bills, David   +4 more
openaire   +2 more sources

Redistribution of Sediment and Particulate Mercury Within Upstream Reaches of Galveston Bay in Response to Hurricane Harvey

Journal of Geophysical Research: Oceans, Volume 131, Issue 8, August 2026.
Abstract Extreme storms and flooding can remobilize legacy contaminants stored in the sediment bed; however, event‐scale models that resolve the transport of these materials remain underdeveloped. This study developed a numerical model of contaminated sediment transport during Hurricane Harvey (August 2017), which struck the upstream reaches of ...
Zhiyun Du, Courtney K. Harris, Roberta Southwood, Dongxiao Yin, Daoyang Bao, Fei Ye, Timothy M. Dellapenna, Kehui Xu, Z. George Xue   +8 more
wiley   +1 more source

Activation of the Lactate Receptor GPR81 Ameliorates Senescence Hallmarks and Improves Muscle Function in Cellular and Progeroid Models of Aging

Aging Cell, Volume 25, Issue 8, August 2026.
Skeletal muscle aging is associated with a decrease in expression of the lactate receptor GPR81. Treating senescent myoblasts in vitro and progeric mice in vivo with GPR81 agonist decreases intramyocellular lipid accumulation and reverses hallmarks of aging. ABSTRACT Skeletal muscle aging is associated with increased lipid accumulation, or myosteatosis,
Pihu Mehrotra, Sai Harsha Bhamidipati, Pedro Lei, John Toftegaard, Debanik Choudhury, Maryam Elsayed, Yali Zhang, Jianmin Wang, Shweta Chitkara, G. Ekin Atilla‐Gokcumen, Song Liu, Stelios T. Andreadis   +11 more
wiley   +1 more source

Comparative transcriptome analysis of Parkinson’s disease and Hutchinson-Gilford progeria syndrome reveals shared susceptible cellular network processes

BMC Medical Genomics, 2020
Background Parkinson’s Disease (PD) and Hutchinson-Gilford Progeria Syndrome (HGPS) are two heterogeneous disorders, which both display molecular and clinical alterations associated with the aging process.
Diana M. Hendrickx, Enrico Glaab
doaj   +1 more source

A Wrinkle in Time: Premature Aging in HGPS and RD [PDF]

, 2008
The aging process can be accelerated by numerous cellular and molecular variables. Progeroid syndromes are one such example. The phenotypes of Hutchinson-Gilford Progeria Syndrome (HGPS) and Restrictive Dermopathy (RD) are both caused by an irregular ...
Fields, Nicole, Clark, Danielle, Levin, Stephanne, Hicks, Spenser, Pospiech, Emily   +4 more
core  

Temsirolimus ameliorates lamin status and nuclear shape in HGPS cells.

, 2016
(A) Representative Western blots of lamin A/C, progerin, and β-actin in control and HGPS total cell extracts isolated from either mock-treated cells or cells treated with 1.0 μM Temsirolimus daily for a period of 9 days.
Diana Gabriel (3608093), Karima Djabali (82182), Leslie B. Gordon (82180)   +2 more
core   +1 more source

Artery‐on‐Chip Demonstrates Mechanical and Functional Features of Healthy and Diseased Living Smooth Muscle Tissue

Advanced Functional Materials, Volume 36, Issue 59, 23 July 2026.
This article details the development of an artery‐on‐chip platform for in vitro arterial disease modeling and therapeutic discovery. It describes the fabrication of a fibrin biomaterial scaffold seeded with iPSC‐derived smooth muscle and endothelial cells, mimicking native artery properties. Two genetic disease models showcase the platform's ability to
Danielle Yarbrough, Roy Chen, Katerina Katsouleas, Jaron Shoemaker, Travis Brady, Tianfang Yu, Jennifer Arthur Ataam, Connor Amelung, Lakshmi Santhanam, Ioannis Karakikes, Sharon Gerecht   +10 more
wiley   +1 more source

Reductions in gammaH2AX response in HGPS cells are cell cycle dependent.

, 2016
(A). Representative fluorescence images of gammaH2AX foci and BrdU staining in middle passage normal and HGPS fibroblasts after Dox treatment. G0/G1 and S phase were indicated by BrdU negative and positive staining respectively. Scale Bar: 5um.
Celeste Witting (3372776), Haoyue Zhang (3372770), Linlin Sun (396058), Di Wu (23906), Kan Cao (454493), Kun Wang (134525), Mason Trappio (3372773)   +6 more
core   +1 more source