Results 41 to 50 of about 4,130 (205)
Cell Reports, 2014 Summary: Advanced age and DNA damage accumulation are prominent risk factors for cancer. The premature aging disorder Hutchinson-Gilford progeria syndrome (HGPS) provides a unique opportunity for studying the interplay between DNA damage and aging ...
Patricia Fernandez +5 more
doaj +1 more source
Vulnerability of progeroid smooth muscle cells to biomechanical forces is mediated by MMP13
Nature Communications, 2020 Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature aging disease and smooth muscle cells are the most affected cells in HGPS individuals. Here, the authors report a microfluidics platform with HGPS induced pluripotent stem cells and show that ...
Patricia R. Pitrez +20 more
doaj +1 more source
Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition. [PDF]
PLoS ONE, 2010 Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare premature aging disorder caused by a de novo heterozygous point mutation G608G (GGC>GGT) within exon 11 of LMNA gene encoding A-type nuclear lamins.
Jackleen Marji +8 more
doaj +1 more source
EMBO Molecular Medicine, 2021 Inflammation is a hallmark of aging and accelerated aging syndromes such as Hutchinson–Gilford progeria syndrome (HGPS). In this study, we present evidence of increased expression of the components of the NLRP3 inflammasome pathway in HGPS skin ...
Alvaro González‐Dominguez +9 more
doaj +1 more source
, 2023 Human Genome Project by Genetic Manipulation lecture for Agriculture, Biology, Botany, Zoology, Chemistry, Biotechnology, Microbiology, and Genetics Students by Salman Saeed Lecturer Botany University College of Management and Sciences Khanewal, Pakistan.
openaire +1 more source
Carbon Energy, EarlyView.Fe‐CoMoO4‐Ov/NF demonstrates significantly improved OER catalytic performance compared to CoMoO4. Specifically, the introduced Fe atoms act as a promoter for surface reconstruction, significantly reducing the energy required for surface reconstruction to generate FeCoOOH. The oxygen vacancies serve as electron channels between the core Fe‐CoMoO4‐Ov and
Chaojie Lyu +4 more
wiley +1 more source
Temsirolimus does not impact HGPS mitochondrial dysfunction.
, 2016 (A) Immunohistochemistry was performed on mock-treated or temsirolimus-treated control (GMO3349C) and HGPS (HGADFN003) fibroblasts (9 days of treatment). Antibodies against NADPH oxidase subunit 4 (Nox4) and progerin were used.
Diana Gabriel (3608093) +2 more
core +1 more source
Sim-Ptychography Imaging of Hutchinson-Gilford Progeria Syndrome (HGPS) Cells
, 2021 180a Wednesday, February 24, 2021 ptychographic module was developed and mounted on a commercial SIM, to simultaneously collect ptychography and SIM data.
Cainero, Isotta +3 more
core +1 more source
Hutchinson–Gilford Progeria Syndrome: Clinical and Molecular Characterization
The Application of Clinical Genetics, 2020 Harry Pachajoa,1,2 Angelica Claros-Hulbert,3,4 Ximena García-Quintero,3,4 Lina Perafan,1 Andres Ramirez,5 Andres F Zea-Vera6 1Faculty of Health Sciences, Congenital Anomalies and Rare Diseases Investigation Center (CIACER), Universidad Icesi, Cali,
Pachajoa H +5 more
doaj
Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome
Genome Medicine, 2020 Background Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals express a mutant
Florian Köhler +9 more
doaj +1 more source