Results 41 to 50 of about 7,722 (240)

A Tissue Engineered Blood Vessel Model of Hutchinson-Gilford Progeria Syndrome Using Human iPSC-derived Smooth Muscle Cells

Scientific Reports, 2017
Hutchison-Gilford Progeria Syndrome (HGPS) is a rare, accelerated aging disorder caused by nuclear accumulation of progerin, an altered form of the Lamin A gene. The primary cause of death is cardiovascular disease at about 14 years. Loss and dysfunction
Leigh Atchison, Haoyue Zhang, Kan Cao, George A. Truskey   +3 more
doaj   +1 more source

Temsirolimus does not impact DNA damage levels in HGPS cells. [PDF]

, 2016
(A) Immunohistochemistry of control (GMO3349C) and HGPS (HGPSFN003) cells either mock-treated or treated with 1.0 μM temsirolimus for a period of 9 days. Antibodies against γH2A.X and 53BP1 were used (n = 4). Scale bar: 20 μm. (B) Immunohistochemistry of
Diana Gabriel (3608093), Karima Djabali (82182), Leslie B. Gordon (82180)   +2 more
core   +1 more source

Behind the scenes of the HGP [PDF]

Nature Genetics, 2003
Future geneticists will probably reflect on the Human Genome Project (HGP) as a milestone in their field. Perhaps it will be recognized alongside the chromosome theory of inheritance, the transforming material as DNA, the double helical structure for the genetic material and the cracking of the genetic code.
openaire   +1 more source

Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome. [PDF]

PLoS ONE, 2016
Compelling evidence suggests that defective DNA damage response (DDR) plays a key role in the premature aging phenotypes in Hutchinson-Gilford progeria syndrome (HGPS).
Haoyue Zhang, Linlin Sun, Kun Wang, Di Wu, Mason Trappio, Celeste Witting, Kan Cao   +6 more
doaj   +1 more source

Modelling premature cardiac aging with induced pluripotent stem cells from a hutchinson-gilford Progeria Syndrome patient

Frontiers in Physiology, 2022
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic disorder that causes accelerated aging and a high risk of cardiovascular complications. However, the underlying mechanisms of cardiac complications of this syndrome are not fully understood ...
Gustavo Monnerat, Gustavo Monnerat, Tais Hanae Kasai-Brunswick, Tais Hanae Kasai-Brunswick, Karina Dutra Asensi, Danubia Silva dos Santos, Raiana Andrade Quintanilha Barbosa, Fernanda Cristina Paccola Mesquita, Joao Paulo Calvancanti Albuquerque, Pires Ferreira Raphaela, Camila Wendt, Kildare Miranda, Gilberto Barbosa Domont, Fábio César Sousa Nogueira, Fábio César Sousa Nogueira, Adriana Bastos Carvalho, Antonio Carlos Campos de Carvalho, Antonio Carlos Campos de Carvalho   +17 more
doaj   +1 more source

gammaH2AX signal reduction was caused by defective ATM activation in HGPS. [PDF]

, 2016
(A). (upper): Western blotting analysis with anti-pATM(S1981), anti-ATM and anti-GAPDH antibodies on serum starvation synchronized middle passage normal and HGPS fibroblasts with or without Dox treatment.
Celeste Witting (3372776), Haoyue Zhang (3372770), Linlin Sun (396058), Di Wu (23906), Kan Cao (454493), Kun Wang (134525), Mason Trappio (3372773)   +6 more
core   +1 more source

Naïve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo

Biology Open, 2012
Summary Hutchinson-Gilford progeria syndrome (HGPS, OMIM 176670) is a rare disorder characterized by segmental accelerated aging and early death from coronary artery disease or stroke. Nearly 90% of HGPS sufferers carry a G608G mutation within exon 11 of
Vera Wenzel, Daniela Roedl, Diana Gabriel, Leslie B. Gordon, Meenhard Herlyn, Reinhard Schneider, Johannes Ring, Karima Djabali   +7 more
doaj   +1 more source

An upregulation in the expression of vanilloid transient potential channels 2 enhances hypotonicity-induced cytosolic Ca²⁺ rise in human induced pluripotent stem cell model of Hutchinson-Gillford Progeria. [PDF]

PLoS ONE, 2014
Hutchinson-Gillford Progeria Syndrome (HGPS) is a fatal genetic disorder characterized by premature aging in multiple organs including the skin, musculoskeletal and cardiovascular systems. It is believed that an increased mechanosensitivity of HGPS cells
Chun-Yin Lo, Yung-Wui Tjong, Jenny Chung-Yee Ho, Chung-Wah Siu, Sin-Ying Cheung, Nelson L Tang, Shan Yu, Hung-Fat Tse, Xiaoqiang Yao   +8 more
doaj   +1 more source

Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution

Molecular Cancer, 2023
Background Colorectal cancer liver metastases (CRCLM) are associated with a poor prognosis, reflected by a five-year survival rate of 14%. Anti-angiogenic therapy through anti-VEGF antibody administration is one of the limited therapies available ...
J. Fleischer, Alexandra Maria Schmitt, Gwendolyn Haas, Xingbo Xu, E. Zeisberg, H. Bohnenberger, Stefan Küffer, L. Teuwen, Philipp Johannes Karras, T. Beissbarth, A. Bleckmann, M. Planque, S. Fendt, P. Vermeulen, M. Ghadimi, J. Kalucka, Tiago De Oliveira, Lena-Christin Conradi   +17 more
semanticscholar   +1 more source

The Impact of Nutrient Restriction and Metformin Treatment on Genome Structure and Function in Hutchinson-Gilford Progeria Syndrome (HGPS) Fibroblasts [PDF]

, 2022
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare disease in which children age at an accelerated rate. Patients suffering from HGPS have a shortened lifespan and succumb to cardiac events at ~14 years of age.
Gillespie, Zoe E
core