Human Herpesvirus 6A Is a Risk Factor for Multiple Sclerosis
Frontiers in Immunology, 2022 The role for human herpesvirus (HHV)-6A or HHV-6B in multiple sclerosis (MS) pathogenesis has been controversial. Possibly because the damage of the virus infection may occur before onset of clinical symptoms and because it has been difficult to detect ...
Wangko Lundström, Rasmus Gustafsson
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Anti-human herpesvirus 6A/B IgG correlates with relapses and progression in multiple sclerosis. [PDF]
PLoS ONE, 2014 To analyze the titers of the IgG and IgM antibodies against human herpesvirus 6A/B (HHV-6A/B) in multiple sclerosis (MS) patients treated with different disease modified therapies (DMTs) along two-years of follow-up.We collected 2163 serum samples from ...
Isabel Ortega-Madueño +7 more
doaj +1 more source
HHV‐6A infection of endometrial epithelial cells affects immune profile and trophoblast invasion
American Journal of Reproductive Immunology, 2019 AbstractProblemWe first reported human herpesvirus (HHV)‐6A DNA presence in 43% of endometrial cells from women with idiopathic infertility, whereas no fertile control women harbored the virus. We investigated the effect of HHV‐6A infection on the immunological status of the endometrium.Method of studyEndometrial biopsies, uterine flushing, and whole ...
Daria Bortolotti +6 more
openalex +5 more sources
Human Herpesvirus 6A Induces Dendritic Cell Death and HMGB1 Release without Virus Replication
Pathogens, 2021 Human herpesvirus 6A (HHV-6A) is a common virus that has important immunomodulatory effects. Dendritic cells (DC) are key players in innate and adaptive immunity and are implicated in the pathogenesis of many human diseases, including infections.
Rasmus Gustafsson
doaj +1 more source
Sensitive detection systems for infectious agents in xenotransplantation*
Xenotransplantation, EarlyView., 2020 Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley +1 more source
Betaherpesvirus Incidence in Saliva Samples From Patients With Hematological Neoplasms: Frequency, Clinic and Diagnostic Insights. [PDF]
J Med VirolABSTRACT Hematological neoplasms (HN) are disorders originating in blood cells that hold significant epidemiological importance. Treatments available for these conditions can induce immunosuppression, and it increases the risk of viral infections and reactivations, mainly by Human betaherpesviruses (HCMV, HHV‐6, and HHV‐7).
Guimarães ACS +9 more
europepmc +2 more sources
Possible Role of Human Herpesvirus 6 as a Trigger of Autoimmune Disease
The Scientific World Journal, 2013 Human herpesvirus 6 (HHV-6) infection is common and has a worldwide distribution. Recently, HHV-6A and HHV-6B have been reclassified into two distinct species based on different biological features (genetic, antigenic, and cell tropism) and disease ...
Francesco Broccolo +2 more
doaj +1 more source
Transcriptome sequencing of neurologic diseases associated genes in HHV-6A infected human astrocyte. [PDF]
Oncotarget, 2016 Human Herpesvirus 6 (HHV-6) has been involved in the development of several central nervous system (CNS) diseases, such as Alzheimer's disease, multiple sclerosis and glioma. In order to identify the pathogenic mechanism of HHV-6A infection, we carried out mRNA-seq study of human astrocyte HA1800 cell with HHV-6A GS infection.
Shao Q +9 more
europepmc +4 more sources
Characterization of human herpesvirus 6A/B U94 as ATPase, helicase, exonuclease and DNA-binding proteins [PDF]
, 2015 Human herpesvirus-6A (HHV-6A) and HHV-6B integrate their genomes into the telomeres of human chromosomes, however, the mechanisms leading to integration remain unknown. HHV-6A/B encode a protein that has been proposed to be involved in integration termed
Collin, Vanessa +8 more
core +1 more source
Human herpesvirus 6A partially suppresses functional properties of DC without viral replication. [PDF]
PLoS ONE, 2013 Human herpesvirus 6A (HHV-6A) is a common virus with a worldwide distribution that has been associated with multiple sclerosis. Whether HHV-6A can replicate in dendritic cells (DC) and how the infection might modulate the functional properties of the ...
Rasmus K L Gustafsson +7 more
doaj +1 more source