Results 231 to 240 of about 260,200 (252)

HI-6-Loaded Vehicle of Liposomes Mediated by an Amphiphilic Pillar[5]arene against Paraoxon Poisoning.

ACS Applied Materials and Interfaces
Organophosphate (OP) intoxication has become a severe common health matter all over the world. For the treatment of acute OP poisoning, the effective intracerebral delivery of acetylcholinesterase reactivators is crucial.
Ziliang Zhang, Shujie Lin, Xiang Yu, Jie Jing, Yahan Zhang, Longming Chen, Jiaqi Han, Zhao Meng, Junyi Chen, Qingbin Meng   +9 more
semanticscholar   +1 more source

The oximes HI-6 and MMB-4 fail to reactivate soman-inhibited human and guinea pig AChE: A kinetic in vitro study.

Toxicology Letters, 2017
Acetylcholinesterase (AChE) inhibited by the organophosphorus nerve (OP) agent soman underlies a spontaneous and extremely rapid dealkylation ("aging") reaction which prevents reactivation by oximes.
F. Worek, H. Thiermann, T. Wille
semanticscholar   +1 more source

Superior efficacy of HI-6 dimethanesulfonate over pralidoxime methylsulfate against Russian VX poisoning in cynomolgus monkeys (Macaca fascicularis).

Toxicology, 2018
Organophosphorus nerve agents still represent a serious risk to human health. In the French armed forces, the current emergency treatment against OP intoxications is a fully licensed wet-dry dual-chambered autoinjector (Ineurope ®), that contains ...
C. Reymond, N. Jaffré, N. Taudon, M. Menneteau, H. Chaussard, J. Denis, C. Castellarin, F. Dhote, F. Dorandeu   +8 more
semanticscholar   +1 more source

Effect of HI-6-loaded brain-targeted metal-organic frameworks on reactivation of central nervous system enzymes.

Journal of Pharmacy and Science
Organophosphate poisoning seriously endangers human life and health. Due to the existence of the blood-brain barrier, most drugs are difficult to reach the effective therapeutic concentration in the brain, thus affecting the effect of central ...
Yanhui Qin, Qian Li, Ning Fan, Feng Yang, Mengmeng Liu, Dongfeng Yin   +5 more
semanticscholar   +1 more source

Crystal Structure of Recombinant Human Acetylcholinesterase with Reactivator HI-6

, 2018
Over 50 years ago, the toxicity of irreversible organophosphate inhibitors targeting human acetylcholinesterase (hAChE) was observed to be stereospecific.
S. Bester, Guelta, J. Cheung, Winemiller, Sue Y. Bae, J. Myslinski, S. Pegan, J. Height   +7 more
semanticscholar   +1 more source

Crystal Structure of Recombinant Human Acetylcholinesterase In Complex with GD and HI-6

, 2021
J. R. McGuire, S. Bester, S. Pegan, J. Height   +3 more
semanticscholar   +1 more source

An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice.

Chemico-Biological Interactions, 2017
A. Calas, J. Dias, Catherine Rousseau, M. Arboléas, Mélanie Touvrey-Loiodice, Guillaume Mercey, L. Jean, P. Renard, F. Nachon   +8 more
semanticscholar   +1 more source

The role of the oximes HI-6 and HS-6 inside human acetylcholinesterase inhibited with nerve agents: a computational study

Journal of Biomolecular Structure and Dynamics, 2018
T. Cuya, A. S. Gonçalves, J. A. V. da Silva, T. Ramalho, K. Kuča, Tanos C. C. França   +5 more
semanticscholar   +1 more source

Rapid-releasing of HI-6 via brain-targeted mesoporous silica nanoparticles for nerve agent detoxification.

Nanoscale, 2016
Jun Yang, Lixue Fan, Feijian Wang, Yuan Luo, Xin Sui, Wan-hua Li, Xiaohong Zhang, Yongan Wang   +7 more
semanticscholar   +1 more source

Crystal Structure of Recombinant Human Acetylcholinesterase Inhibited by A-234 in Complex with Reactivator, HI-6

, 2020
S. Bester, M. Guelta, J. Height, S. Pegan   +3 more
semanticscholar   +1 more source