Results 91 to 100 of about 135,194 (207)

HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.PTK6/Brk is a non-receptor tyrosine kinase overexpressed in cancer.
Blokland, NJG, Broos, AWT, Eccles, SA, Hammond, EM, Harvey, AJ, Pires, IM, Poujade, F-A, Senra, JM, Span, PN   +8 more
core   +3 more sources

Review for "HIF‐1α controls palatal wound healing by regulating macrophage motility via S1P/S1P 1 signaling axis"

, 2021
Takaaki Tsunematsu
openalex   +1 more source

p53-dependent HIF-1α /autophagy mediated glycolysis to support Cr(VI)-induced cell growth and cell migration

Ecotoxicology and Environmental Safety
Cr(VI) is known to be seriously toxic and carcinogenic. Hypoxia-inducible factor-1α (HIF-1α) is a crucial regulator to promote tumor development. In this study, we found that Cr(VI) significantly increased the expression of HIF-1α in A549 cells and in ...
Yanqiu Yang, Bin Song, Minna Guo, Jianfeng Gao, Liping Jiang, Qiujuan Li, Yong Liu, Jun Cao   +7 more
doaj   +1 more source

Small interfering RNA targeting HIF-1α reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro [PDF]

, 2018
Background: : Hypoxia inducible factor-1 has been identified as a potential target to overcome hypoxia-induced radioresistance The aim of the present study was to investigate whether selective HIF-1 inhibition via small interfering RNA (siRNA) targeting ...
Einsele, Herrmann, Fleischer, Markus, Flentje, Michael, Katzer, Astrid, Loeffler, Juergen, Plathow, Christian, Said, Harun, Staab, Adrian, Vordermark, Dirk   +8 more
core  

mTOR signaling pathway regulation HIF-1 α effects on LPS induced intestinal mucosal epithelial model damage

BMC Molecular and Cell Biology
Background Sepsis-induced small-intestinal injury is associated with increased morbidity and mortality. Our previous study and other papers have shown that HIF-1α has a protective effect on intestinal mucosal injury in septic rats.
Zeyong Huang, Wenbin Teng, Liuxu Yao, Kai Xie, Suqin Hang, Rui He, Yuhong Li   +6 more
doaj   +1 more source

HIF-1α mediates isoflurane-induced vascular protection in subarachnoid hemorrhage [PDF]

, 2015
OBJECTIVE: Outcome after aneurysmal subarachnoid hemorrhage (SAH) depends critically on delayed cerebral ischemia (DCI) – a process driven primarily by vascular events including cerebral vasospasm, microvessel thrombosis, and microvascular dysfunction ...
Gidday, Jeffrey M, Han, Byung Hee, Harries, Michael D, Johnson, Andrew W, Milner, Eric, Nelson, James W, Zipfel, Gregory J   +6 more
core   +3 more sources

Variants of the low oxygen sensors EGLN1 and HIF-1AN associated with acute mountain sickness. [PDF]

, 2014
Two low oxygen sensors, Egl nine homolog 1 (EGLN1) and hypoxia-inducible factor 1-α inhibitor (HIF-1AN), play pivotal roles in the regulation of HIF-1α, and high altitude adaption may be involved in the pathology of acute mountain sickness (AMS).
Huang, Lan, Jin, Jun, Li, Huijie, Qin, Jun, Zhang, Enhao, Zhang, Jihang   +5 more
core   +3 more sources

Propranolol inhibits the proliferation, migration and tube formation of hemangioma cells through HIF-1α dependent mechanisms

Brazilian Journal of Medical and Biological Research, 2017
The aim of this study was to investigate the mechanism of propranolol on the regression of hemangiomas. Propranolol-treated hemangioma tissues were collected and the expression of hypoxia inducible factor-1α (HIF-1α) was examined. We also established HIF-
Y.Z. Chen, N. Bai, J.H. Bi, X.W. Liu, G.Q. Xu, L.F. Zhang, X.Q. Li, R. Huo   +7 more
doaj   +1 more source

Tip110 Regulates the Cross Talk between p53 and Hypoxia-Inducible Factor 1α under Hypoxia and Promotes Survival of Cancer Cells [PDF]

, 2015
Hypoxia often occurs under various physiological and pathophysiological conditions, including solid tumors; it is linked to malignant transformation, metastatic progression, and treatment failure or resistance.
Fan, Yan, He, Johnny J., Liu, Ying, Mohammad, Khalid S., Timani, Khalid Amine   +4 more
core   +1 more source

Supplementary Figure 2 from Gain of HIF-1α under Normoxia in Cancer Mediates Immune Adaptation through the AKT/ERK and VEGFA Axes

, 2023
Young‐Ho Lee, Hyun Cheol Bae, Kyung Hee Noh, Kwon‐Ho Song, Sang-kyu Ye, Chih-Ping Mao, Kyung-Mi Lee, T.-C. Wu, Tae Woo Kim   +8 more
openalex   +1 more source